prr5l protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Coexpression

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[Homology]

Score

prr5l

Si:ch211-147k10.5. (355 aa)

Predicted Functional Partners:

W5LZJ4_LEPOC

0.854

pcna

0.848

mlst8

0.832

mtor

0.832

rbl2

0.823

rbl1

0.823

rb1

0.823

skp1

0.818

LOC102682951

0.797

cdkn1a

0.797

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102682951	pcna	ENSLOCP00000000989	ENSLOCP00000019251	Cyclin-dependent kinase inhibitor 1Cb.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.818
LOC102682951	prr5l	ENSLOCP00000000989	ENSLOCP00000001241	Cyclin-dependent kinase inhibitor 1Cb.	Si:ch211-147k10.5.	0.797
LOC102682951	rb1	ENSLOCP00000000989	ENSLOCP00000010825	Cyclin-dependent kinase inhibitor 1Cb.	Retinoblastoma 1.	0.744
LOC102682951	rbl1	ENSLOCP00000000989	ENSLOCP00000008944	Cyclin-dependent kinase inhibitor 1Cb.	Retinoblastoma-like 1 (p107).	0.750
LOC102682951	rbl2	ENSLOCP00000000989	ENSLOCP00000008720	Cyclin-dependent kinase inhibitor 1Cb.	Retinoblastoma-like 2 (p130).	0.750
LOC102682951	skp1	ENSLOCP00000000989	ENSLOCP00000012539	Cyclin-dependent kinase inhibitor 1Cb.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.951
W5LZJ4_LEPOC	mlst8	ENSLOCP00000001551	ENSLOCP00000006275	MAPK associated protein 1.	MTOR associated protein, LST8 homolog (S. cerevisiae).	0.999
W5LZJ4_LEPOC	mtor	ENSLOCP00000001551	ENSLOCP00000007715	MAPK associated protein 1.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.999
W5LZJ4_LEPOC	prr5l	ENSLOCP00000001551	ENSLOCP00000001241	MAPK associated protein 1.	Si:ch211-147k10.5.	0.854
cdkn1a	pcna	ENSLOCP00000015421	ENSLOCP00000019251	Cyclin-dependent kinase inhibitor 1A.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.818
cdkn1a	prr5l	ENSLOCP00000015421	ENSLOCP00000001241	Cyclin-dependent kinase inhibitor 1A.	Si:ch211-147k10.5.	0.797
cdkn1a	rb1	ENSLOCP00000015421	ENSLOCP00000010825	Cyclin-dependent kinase inhibitor 1A.	Retinoblastoma 1.	0.744
cdkn1a	rbl1	ENSLOCP00000015421	ENSLOCP00000008944	Cyclin-dependent kinase inhibitor 1A.	Retinoblastoma-like 1 (p107).	0.750
cdkn1a	rbl2	ENSLOCP00000015421	ENSLOCP00000008720	Cyclin-dependent kinase inhibitor 1A.	Retinoblastoma-like 2 (p130).	0.750
cdkn1a	skp1	ENSLOCP00000015421	ENSLOCP00000012539	Cyclin-dependent kinase inhibitor 1A.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.951
mlst8	W5LZJ4_LEPOC	ENSLOCP00000006275	ENSLOCP00000001551	MTOR associated protein, LST8 homolog (S. cerevisiae).	MAPK associated protein 1.	0.999
mlst8	mtor	ENSLOCP00000006275	ENSLOCP00000007715	MTOR associated protein, LST8 homolog (S. cerevisiae).	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.999
mlst8	prr5l	ENSLOCP00000006275	ENSLOCP00000001241	MTOR associated protein, LST8 homolog (S. cerevisiae).	Si:ch211-147k10.5.	0.832
mtor	W5LZJ4_LEPOC	ENSLOCP00000007715	ENSLOCP00000001551	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	MAPK associated protein 1.	0.999
mtor	mlst8	ENSLOCP00000007715	ENSLOCP00000006275	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	MTOR associated protein, LST8 homolog (S. cerevisiae).	0.999

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006383

Transcription by RNA polymerase III

6 of 20

2.48

4.96

1.46e-10

GO:0006384

Transcription initiation from RNA polymerase III promoter

4 of 6

2.83

3.83

7.83e-08

GO:0006351

Transcription, DNA-templated

8 of 185

1.64

2.93

2.04e-09

GO:0006352

DNA-templated transcription, initiation

5 of 54

1.97

2.8

8.23e-07

GO:0070898

RNA polymerase III preinitiation complex assembly

2 of 2

3.0

1.61

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140223

General transcription initiation factor activity

3 of 16

2.28

1.61

0.00092

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

3.0

1.41

0.0028

GO:0000995

RNA polymerase III general transcription initiation factor activity

2 of 2

3.0

1.41

0.0028

GO:0043546

Molybdopterin cofactor binding

2 of 5

2.61

1.31

0.0041

GO:0030151

Molybdenum ion binding

2 of 11

2.26

1.14

0.0077

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090576

RNA polymerase III transcription regulator complex

5 of 5

3.0

5.49

6.98e-11

GO:0000127

Transcription factor TFIIIC complex

3 of 3

3.0

2.96

4.07e-06

GO:0000126

Transcription factor TFIIIB complex

2 of 2

3.0

1.64

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:834

Transcription factor TFIIIC complex, and Histidine phosphatase superfamily, clade-1

4 of 5

2.91

3.77

1.14e-07

CL:1661

RNA polymerase III complex, and Transcription factor TFIIIB complex

3 of 20

2.18

1.84

0.00028

CL:13449

Oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor, and Cytochrome b5, heme-binding site

2 of 7

2.46

1.42

0.0024

CL:1481

RNA Polymerase II Pre-transcription Events, and RNA polymerase

4 of 117

1.54

1.41

0.00049

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76066

RNA Polymerase III Transcription Initiation From Type 2 Promoter

7 of 24

2.47

6.21

1.98e-13

MAP-76061

RNA Polymerase III Transcription Initiation From Type 1 Promoter

7 of 24

2.47

6.21

1.98e-13

MAP-76046

RNA Polymerase III Transcription Initiation

7 of 24

2.47

6.21

1.98e-13

MAP-74158

RNA Polymerase III Transcription

7 of 24

2.47

6.21

1.98e-13

MAP-74160

Gene expression (Transcription)

8 of 540

1.17

1.45

9.18e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03404

Mo-co oxidoreductase dimerisation domain

2 of 4

2.7

1.03

0.0135

PF00174

Oxidoreductase molybdopterin binding domain

2 of 4

2.7

1.03

0.0135

PF00970

Oxidoreductase FAD-binding domain

2 of 7

2.46

1.02

0.0135

PF00175

Oxidoreductase NAD-binding domain

2 of 15

2.13

0.82

0.0304

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

2 of 4

2.7

0.79

0.0374

IPR008335

Eukaryotic molybdopterin oxidoreductase

2 of 4

2.7

0.79

0.0374

IPR005066

Moybdenum cofactor oxidoreductase, dimerisation

2 of 4

2.7

0.79

0.0374

IPR000572

Oxidoreductase, molybdopterin-binding domain

2 of 4

2.7

0.79

0.0374

IPR008333

Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain

2 of 7

2.46

0.78

0.0374

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00384

DNA binding domain with preference for A/T rich regions

2 of 11

2.26

0.9

0.0218

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 24

1.92

0.71

0.0452

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