Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pik3caPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1087 aa)    
Predicted Functional Partners:
pik3r2
Phosphoinositide-3-kinase, regulatory subunit 2 (beta).
    
 0.987
pik3r3
Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).
    
 0.987
pik3r1
Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).
    
 0.987
cdc42
Cell division cycle 42.
    
 0.985
pdpk1
3-phosphoinositide dependent protein kinase 1a.
    
 0.976
mtor
Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.
    
0.973
LOC102698253
Cell division cycle 42, like.
    
 0.972
W5NLK8_LEPOC
Insulin receptor substrate 1.
    
 0.971
rac1
Rac family small GTPase 1b.
   
 0.969
RAC3
Rac family small GTPase 3.
   
 0.969
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
Server load: medium (44%) [HD]