Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
W5LZA1_LEPOCDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (409 aa)    
Predicted Functional Partners:
mvk
Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 
 
 0.994
LOC102698835
Isopentenyl-diphosphate delta isomerase 1.
  
 
 0.992
W5MGX1_LEPOC
RUN and SH3 domain containing 1.
  
 0.946
hmgcs1
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
  
 
 0.939
W5MSU6_LEPOC
Squalene epoxidase a.
   
  
 0.895
lss
Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.
  
 
 0.884
ggps1
Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family.
  
 0.881
W5MDX5_LEPOC
F-box protein 40, tandem duplicate 1.
  
 0.878
aarsd1
Alanyl-tRNA synthetase domain containing 1.
   
 
 0.878
fbxo30
F-box protein 30a.
  
 0.878
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
Server load: low (16%) [HD]