Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pdgfaPlatelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (220 aa)    
Predicted Functional Partners:
pdgfrb
Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.987
FLT3
Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.986
pdgfc
Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family.
     
 0.986
PDGFB
Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.
    
 0.986
pdgfd
Platelet derived growth factor d; Belongs to the PDGF/VEGF growth factor family.
     
 0.982
W5N9Y7_LEPOC
Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.972
W5N848_LEPOC
Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family.
     
 0.945
W5MM29_LEPOC
Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.
     
 0.941
egf
Epidermal growth factor.
     
 0.922
hgf
Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.
     
 0.914
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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