RTEL1 protein (Lepisosteus oculatus) - STRING interaction network

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RTEL1

Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1117 aa)

Predicted Functional Partners:

topbp1

0.946

bard1

0.928

W5N048_LEPOC

0.924

W5MW35_LEPOC

0.904

mre11

0.895

mlh1

0.868

W5MPN7_LEPOC

0.867

W5M0D4_LEPOC

0.863

W5MXW8_LEPOC

0.860

blm

0.845

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RTEL1	W5M0D4_LEPOC	ENSLOCP00000001964	ENSLOCP00000001841	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	SMC5-SMC6 complex localization factor 1.	0.863
RTEL1	W5MPN7_LEPOC	ENSLOCP00000001964	ENSLOCP00000010346	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	PMS1 homolog 2, mismatch repair system component.	0.867
RTEL1	W5MW35_LEPOC	ENSLOCP00000001964	ENSLOCP00000012594	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	Nibrin.	0.904
RTEL1	W5MXW8_LEPOC	ENSLOCP00000001964	ENSLOCP00000013227	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	WRN RecQ like helicase.	0.860
RTEL1	W5N048_LEPOC	ENSLOCP00000001964	ENSLOCP00000014007	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	Uncharacterized protein.	0.924
RTEL1	bard1	ENSLOCP00000001964	ENSLOCP00000005344	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	BRCA1 associated RING domain 1.	0.928
RTEL1	blm	ENSLOCP00000001964	ENSLOCP00000017609	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	BLM RecQ like helicase.	0.845
RTEL1	mlh1	ENSLOCP00000001964	ENSLOCP00000005828	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.868
RTEL1	mre11	ENSLOCP00000001964	ENSLOCP00000009125	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.895
RTEL1	topbp1	ENSLOCP00000001964	ENSLOCP00000014826	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	DNA topoisomerase II binding protein 1.	0.946
W5M0D4_LEPOC	RTEL1	ENSLOCP00000001841	ENSLOCP00000001964	SMC5-SMC6 complex localization factor 1.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.863
W5M0D4_LEPOC	W5MW35_LEPOC	ENSLOCP00000001841	ENSLOCP00000012594	SMC5-SMC6 complex localization factor 1.	Nibrin.	0.960
W5M0D4_LEPOC	W5MXW8_LEPOC	ENSLOCP00000001841	ENSLOCP00000013227	SMC5-SMC6 complex localization factor 1.	WRN RecQ like helicase.	0.989
W5M0D4_LEPOC	W5N048_LEPOC	ENSLOCP00000001841	ENSLOCP00000014007	SMC5-SMC6 complex localization factor 1.	Uncharacterized protein.	0.920
W5M0D4_LEPOC	bard1	ENSLOCP00000001841	ENSLOCP00000005344	SMC5-SMC6 complex localization factor 1.	BRCA1 associated RING domain 1.	0.965
W5M0D4_LEPOC	blm	ENSLOCP00000001841	ENSLOCP00000017609	SMC5-SMC6 complex localization factor 1.	BLM RecQ like helicase.	0.899
W5M0D4_LEPOC	mre11	ENSLOCP00000001841	ENSLOCP00000009125	SMC5-SMC6 complex localization factor 1.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.915
W5MPN7_LEPOC	RTEL1	ENSLOCP00000010346	ENSLOCP00000001964	PMS1 homolog 2, mismatch repair system component.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.867
W5MPN7_LEPOC	W5MW35_LEPOC	ENSLOCP00000010346	ENSLOCP00000012594	PMS1 homolog 2, mismatch repair system component.	Nibrin.	0.417
W5MPN7_LEPOC	W5MXW8_LEPOC	ENSLOCP00000010346	ENSLOCP00000013227	PMS1 homolog 2, mismatch repair system component.	WRN RecQ like helicase.	0.556

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