STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1117 aa)    
Predicted Functional Partners:
W5MXW8_LEPOC
WRN RecQ like helicase.
  
 0.990
W5M0D4_LEPOC
SMC5-SMC6 complex localization factor 1.
   
 0.934
W5N048_LEPOC
Uncharacterized protein.
   
 0.934
mlh1
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).
   
 0.926
topbp1
DNA topoisomerase II binding protein 1.
   
 0.921
LOC102695873
Excision repair cross-complementation group 3.
   
 0.919
LOC102695765
General transcription factor IIH subunit.
    
 0.917
LOC107075828
BSD domain-containing protein.
    
 0.916
gtf2h3
General transcription factor IIH, polypeptide 3.
    
 0.915
mnat1
CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.
    
 0.915
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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