node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTU2 | ctu1 | ENSLOCP00000005813 | ENSLOCP00000001980 | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | 0.947 |
CTU2 | urm1 | ENSLOCP00000005813 | ENSLOCP00000003256 | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically [...] | 0.772 |
FTSJ3 | W5LZD6_LEPOC | ENSLOCP00000010943 | ENSLOCP00000001493 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. | Uncharacterized protein. | 0.997 |
FTSJ3 | ctu1 | ENSLOCP00000010943 | ENSLOCP00000001980 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | 0.880 |
FTSJ3 | ddx56 | ENSLOCP00000010943 | ENSLOCP00000018685 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. | DEAD (Asp-Glu-Ala-Asp) box helicase 56. | 0.967 |
FTSJ3 | gmps | ENSLOCP00000010943 | ENSLOCP00000003762 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. | Guanine monophosphate synthase. | 0.726 |
FTSJ3 | rbm34 | ENSLOCP00000010943 | ENSLOCP00000019582 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. | RNA binding motif protein 34. | 0.978 |
W5LZD6_LEPOC | FTSJ3 | ENSLOCP00000001493 | ENSLOCP00000010943 | Uncharacterized protein. | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. | 0.997 |
W5LZD6_LEPOC | ctu1 | ENSLOCP00000001493 | ENSLOCP00000001980 | Uncharacterized protein. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | 0.859 |
W5LZD6_LEPOC | ddx56 | ENSLOCP00000001493 | ENSLOCP00000018685 | Uncharacterized protein. | DEAD (Asp-Glu-Ala-Asp) box helicase 56. | 0.981 |
W5LZD6_LEPOC | gmps | ENSLOCP00000001493 | ENSLOCP00000003762 | Uncharacterized protein. | Guanine monophosphate synthase. | 0.520 |
W5LZD6_LEPOC | rbm34 | ENSLOCP00000001493 | ENSLOCP00000019582 | Uncharacterized protein. | RNA binding motif protein 34. | 0.950 |
W5M225_LEPOC | asl | ENSLOCP00000002433 | ENSLOCP00000006414 | Glucose-6-phosphate isomerase; Belongs to the GPI family. | Argininosuccinate lyase. | 0.670 |
W5M225_LEPOC | ctu1 | ENSLOCP00000002433 | ENSLOCP00000001980 | Glucose-6-phosphate isomerase; Belongs to the GPI family. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | 0.890 |
W5M225_LEPOC | gmps | ENSLOCP00000002433 | ENSLOCP00000003762 | Glucose-6-phosphate isomerase; Belongs to the GPI family. | Guanine monophosphate synthase. | 0.435 |
asl | W5M225_LEPOC | ENSLOCP00000006414 | ENSLOCP00000002433 | Argininosuccinate lyase. | Glucose-6-phosphate isomerase; Belongs to the GPI family. | 0.670 |
asl | atic | ENSLOCP00000006414 | ENSLOCP00000012237 | Argininosuccinate lyase. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.774 |
asl | ctu1 | ENSLOCP00000006414 | ENSLOCP00000001980 | Argininosuccinate lyase. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | 0.884 |
atic | asl | ENSLOCP00000012237 | ENSLOCP00000006414 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Argininosuccinate lyase. | 0.774 |
atic | ctu1 | ENSLOCP00000012237 | ENSLOCP00000001980 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. | 0.841 |