node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FANCM | W5M1X9_LEPOC | ENSLOCP00000013912 | ENSLOCP00000002387 | FA complementation group M. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.999 |
FANCM | W5MXW8_LEPOC | ENSLOCP00000013912 | ENSLOCP00000013227 | FA complementation group M. | WRN RecQ like helicase. | 0.999 |
FANCM | blm | ENSLOCP00000013912 | ENSLOCP00000017609 | FA complementation group M. | BLM RecQ like helicase. | 0.999 |
FANCM | ercc4 | ENSLOCP00000013912 | ENSLOCP00000009117 | FA complementation group M. | Excision repair cross-complementation group 4. | 0.839 |
FANCM | recql4 | ENSLOCP00000013912 | ENSLOCP00000009084 | FA complementation group M. | RecQ helicase-like 4. | 0.999 |
FANCM | rmi1 | ENSLOCP00000013912 | ENSLOCP00000022069 | FA complementation group M. | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). | 0.999 |
FANCM | rmi2 | ENSLOCP00000013912 | ENSLOCP00000004938 | FA complementation group M. | RecQ mediated genome instability 2. | 0.999 |
FANCM | rpa1 | ENSLOCP00000013912 | ENSLOCP00000007742 | FA complementation group M. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.999 |
FANCM | rpa3 | ENSLOCP00000013912 | ENSLOCP00000013652 | FA complementation group M. | Replication protein A3. | 0.980 |
FANCM | tdrd3 | ENSLOCP00000013912 | ENSLOCP00000005587 | FA complementation group M. | Tudor domain containing 3. | 0.999 |
W5M1X9_LEPOC | FANCM | ENSLOCP00000002387 | ENSLOCP00000013912 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | FA complementation group M. | 0.999 |
W5M1X9_LEPOC | W5MXW8_LEPOC | ENSLOCP00000002387 | ENSLOCP00000013227 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | WRN RecQ like helicase. | 0.999 |
W5M1X9_LEPOC | blm | ENSLOCP00000002387 | ENSLOCP00000017609 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | BLM RecQ like helicase. | 0.977 |
W5M1X9_LEPOC | ercc4 | ENSLOCP00000002387 | ENSLOCP00000009117 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Excision repair cross-complementation group 4. | 0.955 |
W5M1X9_LEPOC | recql4 | ENSLOCP00000002387 | ENSLOCP00000009084 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | RecQ helicase-like 4. | 0.956 |
W5M1X9_LEPOC | rmi1 | ENSLOCP00000002387 | ENSLOCP00000022069 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). | 0.990 |
W5M1X9_LEPOC | rmi2 | ENSLOCP00000002387 | ENSLOCP00000004938 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | RecQ mediated genome instability 2. | 0.961 |
W5M1X9_LEPOC | rpa1 | ENSLOCP00000002387 | ENSLOCP00000007742 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.957 |
W5M1X9_LEPOC | rpa3 | ENSLOCP00000002387 | ENSLOCP00000013652 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Replication protein A3. | 0.973 |
W5M1X9_LEPOC | tdrd3 | ENSLOCP00000002387 | ENSLOCP00000005587 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Tudor domain containing 3. | 0.994 |