STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC102696373Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. (523 aa)    
Predicted Functional Partners:
W5NCM0_LEPOC
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
  
0.921
hsd17b3
Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 0.902
hsd3b1
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family.
  
 0.899
W5NNT2_LEPOC
Sulfite oxidase; Belongs to the cytochrome b5 family.
     
 0.874
W5M408_LEPOC
Acetylserotonin O-methyltransferase-like.
     
 0.864
hsd17b2
Hydroxysteroid (17-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.862
W5N6Z3_LEPOC
Cytochrome P450, family 19, subfamily A, polypeptide 1a; Belongs to the cytochrome P450 family.
  
 
0.858
W5MA66_LEPOC
Uncharacterized protein.
  
0.857
srd5a1
3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
     
 0.853
hsd11b2
Hydroxysteroid (11-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.843
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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