W5M3R0_LEPOC protein (Lepisosteus oculatus) - STRING interaction network

[ The below analysis is limited to the network nodes included in the specified statistical background ]

Network Stats

number of nodes:

number of edges:

average node degree:

2.91

avg. local clustering coefficient:

0.876

expected number of edges:

PPI enrichment p-value:

0.123

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031386

Protein tag

2 of 13

2.96

1.72

0.0060

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:38507

Mixed, incl. Myelin basic protein, and Vitellinogen, beta-sheet shell

2 of 5

3.37

2.06

0.0023

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-975163

IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

2 of 12

2.99

2.03

0.0024

MAP-9708530

Regulation of BACH1 activity

2 of 11

3.03

2.03

0.0024

MAP-937042

IRAK2 mediated activation of TAK1 complex

2 of 12

2.99

2.03

0.0024

MAP-8948747

Regulation of PTEN localization

2 of 10

3.07

2.03

0.0024

MAP-3134975

Regulation of innate immune responses to cytosolic DNA

2 of 12

2.99

2.03

0.0024

MAP-9664873

Pexophagy

2 of 16

2.87

2.02

0.0024

MAP-937072

TRAF6-mediated induction of TAK1 complex within TLR4 complex

2 of 13

2.96

2.02

0.0024

MAP-8866427

VLDLR internalisation and degradation

2 of 16

2.87

2.02

0.0024

MAP-8849469

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

2 of 14

2.93

2.02

0.0024

MAP-5689877

Josephin domain DUBs

2 of 14

2.93

2.02

0.0024

MAP-2122948

Activated NOTCH1 Transmits Signal to the Nucleus

2 of 16

2.87

2.02

0.0024

MAP-209560

NF-kB is activated and signals survival

2 of 14

2.93

2.02

0.0024

MAP-209543

p75NTR recruits signalling complexes

2 of 13

2.96

2.02

0.0024

MAP-205043

NRIF signals cell death from the nucleus

2 of 13

2.96

2.02

0.0024

MAP-174113

SCF-beta-TrCP mediated degradation of Emi1

2 of 14

2.93

2.02

0.0024

MAP-1253288

Downregulation of ERBB4 signaling

2 of 13

2.96

2.02

0.0024

MAP-2173791

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

2 of 19

2.79

2.01

0.0024

MAP-2173788

Downregulation of TGF-beta receptor signaling

2 of 17

2.84

2.01

0.0024

MAP-193639

p75NTR signals via NF-kB

2 of 17

2.84

2.01

0.0024

MAP-1295596

Spry regulation of FGF signaling

2 of 20

2.77

2.01

0.0024

MAP-4641263

Regulation of FZD by ubiquitination

2 of 22

2.73

2.0

0.0024

MAP-110312

Translesion synthesis by REV1

2 of 24

2.69

2.0

0.0024

MAP-901032

ER Quality Control Compartment (ERQC)

2 of 26

2.66

1.99

0.0024

MAP-5656121

Translesion synthesis by POLI

2 of 25

2.67

1.99

0.0024

MAP-5655862

Translesion synthesis by POLK

2 of 25

2.67

1.99

0.0024

MAP-450321

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

2 of 26

2.66

1.99

0.0024

MAP-450302

Activated TAK1 mediates p38 MAPK activation

2 of 27

2.64

1.99

0.0024

MAP-2173795

Downregulation of SMAD2/3:SMAD4 transcriptional activity

2 of 26

2.66

1.99

0.0024

MAP-9648002

RAS processing

2 of 32

2.57

1.98

0.0024

MAP-912631

Regulation of signaling by CBL

2 of 29

2.61

1.98

0.0024

MAP-6807004

Negative regulation of MET activity

2 of 31

2.58

1.98

0.0024

MAP-5696397

Gap-filling DNA repair synthesis and ligation in GG-NER

2 of 32

2.57

1.98

0.0024

MAP-5654733

Negative regulation of FGFR4 signaling

2 of 33

2.55

1.98

0.0024

MAP-5654732

Negative regulation of FGFR3 signaling

2 of 31

2.58

1.98

0.0024

MAP-1980143

Signaling by NOTCH1

2 of 32

2.57

1.98

0.0024

MAP-174048

APC/C:Cdc20 mediated degradation of Cyclin B

2 of 32

2.57

1.98

0.0024

MAP-110320

Translesion Synthesis by POLH

2 of 30

2.59

1.98

0.0024

MAP-901042

Calnexin/calreticulin cycle

2 of 34

2.54

1.97

0.0024

MAP-8863795

Downregulation of ERBB2 signaling

2 of 34

2.54

1.97

0.0024

MAP-5675482

Regulation of necroptotic cell death

2 of 34

2.54

1.97

0.0024

MAP-5213460

RIPK1-mediated regulated necrosis

2 of 34

2.54

1.97

0.0024

MAP-2173796

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

2 of 35

2.53

1.97

0.0024

MAP-179409

APC-Cdc20 mediated degradation of Nek2A

2 of 35

2.53

1.97

0.0024

MAP-8866652

Synthesis of active ubiquitin: roles of E1 and E2 enzymes

2 of 39

2.48

1.96

0.0024

MAP-6783310

Fanconi Anemia Pathway

2 of 41

2.46

1.96

0.0024

MAP-5689896

Ovarian tumor domain proteases

2 of 40

2.47

1.96

0.0024

MAP-5654727

Negative regulation of FGFR2 signaling

2 of 39

2.48

1.96

0.0024

MAP-5654726

Negative regulation of FGFR1 signaling

2 of 38

2.49

1.96

0.0024

MAP-5357956

TNFR1-induced NFkappaB signaling pathway

2 of 41

2.46

1.96

0.0024

MAP-182971

EGFR downregulation

2 of 41

2.46

1.96

0.0024

MAP-168638

NOD1/2 Signaling Pathway

2 of 39

2.48

1.96

0.0024

MAP-110314

Recognition of DNA damage by PCNA-containing replication complex

2 of 40

2.47

1.96

0.0024

MAP-9646399

Aggrephagy

2 of 46

2.41

1.95

0.0024

MAP-6806003

Regulation of TP53 Expression and Degradation

2 of 46

2.41

1.95

0.0024

MAP-6804757

Regulation of TP53 Degradation

2 of 43

2.44

1.95

0.0024

MAP-5654743

Signaling by FGFR4

2 of 45

2.42

1.95

0.0024

MAP-5654741

Signaling by FGFR3

2 of 45

2.42

1.95

0.0024

MAP-532668

N-glycan trimming in the ER and Calnexin/Calreticulin cycle

2 of 44

2.43

1.95

0.0024

MAP-512988

Interleukin-3, Interleukin-5 and GM-CSF signaling

2 of 42

2.45

1.95

0.0024

MAP-176408

Regulation of APC/C activators between G1/S and early anaphase

2 of 46

2.41

1.95

0.0024

MAP-917729

Endosomal Sorting Complex Required For Transport (ESCRT)

2 of 48

2.39

1.94

0.0024

MAP-5696400

Dual Incision in GG-NER

2 of 49

2.38

1.94

0.0024

MAP-5696394

DNA Damage Recognition in GG-NER

2 of 48

2.39

1.94

0.0024

MAP-2173789

TGF-beta receptor signaling activates SMADs

2 of 48

2.39

1.94

0.0024

MAP-202424

Downstream TCR signaling

2 of 47

2.4

1.94

0.0024

MAP-1834949

Cytosolic sensors of pathogen-associated DNA

2 of 48

2.39

1.94

0.0024

MAP-9762114

GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

2 of 55

2.33

1.93

0.0024

MAP-8852276

The role of GTSE1 in G2/M progression after G2 checkpoint

2 of 51

2.36

1.93

0.0024

MAP-75815

Ubiquitin-dependent degradation of Cyclin D

2 of 53

2.35

1.93

0.0024

MAP-69613

p53-Independent G1/S DNA damage checkpoint

2 of 54

2.34

1.93

0.0024

MAP-69610

p53-Independent DNA Damage Response

2 of 54

2.34

1.93

0.0024

MAP-69601

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

2 of 54

2.34

1.93

0.0024

MAP-5218859

Regulated Necrosis

2 of 51

2.36

1.93

0.0024

MAP-1236394

Signaling by ERBB4

2 of 51

2.36

1.93

0.0024

MAP-8964043

Plasma lipoprotein clearance

2 of 56

2.32

1.92

0.0024

MAP-5696395

Formation of Incision Complex in GG-NER

2 of 57

2.32

1.92

0.0024

MAP-5610780

Degradation of GLI1 by the proteasome

2 of 59

2.3

1.92

0.0024

MAP-4641257

Degradation of AXIN

2 of 59

2.3

1.92

0.0024

MAP-3769402

Deactivation of the beta-catenin transactivating complex

2 of 56

2.32

1.92

0.0024

MAP-349425

Autodegradation of the E3 ubiquitin ligase COP1

2 of 56

2.32

1.92

0.0024

MAP-8941858

Regulation of RUNX3 expression and activity

2 of 60

2.29

1.91

0.0024

MAP-8939902

Regulation of RUNX2 expression and activity

2 of 62

2.28

1.91

0.0024

MAP-8866654

E3 ubiquitin ligases ubiquitinate target proteins

2 of 61

2.29

1.91

0.0024

MAP-8854050

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

2 of 61

2.29

1.91

0.0024

MAP-69541

Stabilization of p53

2 of 61

2.29

1.91

0.0024

MAP-69236

G1 Phase

2 of 63

2.27

1.91

0.0024

MAP-69231

Cyclin D associated events in G1

2 of 63

2.27

1.91

0.0024

MAP-6781823

Formation of TC-NER Pre-Incision Complex

2 of 60

2.29

1.91

0.0024

MAP-5654736

Signaling by FGFR1

2 of 61

2.29

1.91

0.0024

MAP-5610785

GLI3 is processed to GLI3R by the proteasome

2 of 63

2.27

1.91

0.0024

MAP-4641258

Degradation of DVL

2 of 60

2.29

1.91

0.0024

MAP-450408

AUF1 (hnRNP D0) binds and destabilizes mRNA

2 of 64

2.27

1.91

0.0024

MAP-2173793

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

2 of 64

2.27

1.91

0.0024

MAP-1227986

Signaling by ERBB2

2 of 60

2.29

1.91

0.0024

MAP-9759194

Nuclear events mediated by NFE2L2

2 of 66

2.25

1.9

0.0024

MAP-5676590

NIK-->noncanonical NF-kB signaling

2 of 65

2.26

1.9

0.0024

MAP-5607761

Dectin-1 mediated noncanonical NF-kB signaling

2 of 65

2.26

1.9

0.0024

MAP-187577

SCF(Skp2)-mediated degradation of p27/p21

2 of 68

2.24

1.9

0.0024

MAP-177929

Signaling by EGFR

2 of 68

2.24

1.9

0.0024

MAP-9006927

Signaling by Non-Receptor Tyrosine Kinases

2 of 70

2.23

1.89

0.0024

MAP-8848021

Signaling by PTK6

2 of 70

2.23

1.89

0.0024

MAP-5685942

HDR through Homologous Recombination (HRR)

2 of 69

2.23

1.89

0.0024

MAP-5675221

Negative regulation of MAPK pathway

2 of 69

2.23

1.89

0.0024

MAP-5656169

Termination of translesion DNA synthesis

2 of 70

2.23

1.89

0.0024

MAP-5357905

Regulation of TNFR1 signaling

2 of 70

2.23

1.89

0.0024

MAP-4608870

Asymmetric localization of PCP proteins

2 of 70

2.23

1.89

0.0024

MAP-450294

MAP kinase activation

2 of 71

2.22

1.89

0.0024

MAP-202403

TCR signaling

2 of 70

2.23

1.89

0.0024

MAP-168643

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

2 of 70

2.23

1.89

0.0024

MAP-157118

Signaling by NOTCH

2 of 69

2.23

1.89

0.0024

MAP-1234176

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

2 of 69

2.23

1.89

0.0024

MAP-1169091

Activation of NF-kappaB in B cells

2 of 69

2.23

1.89

0.0024

MAP-8939236

RUNX1 regulates transcription of genes involved in differentiation of HSCs

2 of 76

2.19

1.88

0.0024

MAP-69580

p53-Dependent G1/S DNA damage checkpoint

2 of 76

2.19

1.88

0.0024

MAP-69563

p53-Dependent G1 DNA Damage Response

2 of 76

2.19

1.88

0.0024

MAP-68949

Orc1 removal from chromatin

2 of 75

2.2

1.88

0.0024

MAP-448424

Interleukin-17 signaling

2 of 78

2.18

1.88

0.0024

MAP-174084

Autodegradation of Cdh1 by Cdh1:APC/C

2 of 74

2.2

1.88

0.0024

MAP-1234174

Cellular response to hypoxia

2 of 74

2.2

1.88

0.0024

MAP-110313

Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

2 of 78

2.18

1.88

0.0024

MAP-75893

TNF signaling

2 of 82

2.16

1.87

0.0024

MAP-69615

G1/S DNA Damage Checkpoints

2 of 79

2.17

1.87

0.0024

MAP-5654738

Signaling by FGFR2

2 of 83

2.15

1.87

0.0024

MAP-5358346

Hedgehog ligand biogenesis

2 of 80

2.17

1.87

0.0024

MAP-204998

Cell death signalling via NRAGE, NRIF and NADE

2 of 81

2.16

1.87

0.0024

MAP-174154

APC/C:Cdc20 mediated degradation of Securin

2 of 79

2.17

1.87

0.0024

MAP-73893

DNA Damage Bypass

2 of 86

2.14

1.86

0.0024

MAP-69656

Cyclin A:Cdk2-associated events at S phase entry

2 of 86

2.14

1.86

0.0024

MAP-69202

Cyclin E associated events during G1/S transition

2 of 84

2.15

1.86

0.0024

MAP-69017

CDK-mediated phosphorylation and removal of Cdc6

2 of 84

2.15

1.86

0.0024

MAP-6806834

Signaling by MET

2 of 85

2.14

1.86

0.0024

MAP-6782210

Gap-filling DNA repair synthesis and ligation in TC-NER

2 of 84

2.15

1.86

0.0024

MAP-6782135

Dual incision in TC-NER

2 of 87

2.13

1.86

0.0024

MAP-179419

APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint

2 of 86

2.14

1.86

0.0024

MAP-174184

Cdc20:Phospho-APC/C mediated degradation of Cyclin A

2 of 85

2.14

1.86

0.0024

MAP-174178

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

2 of 86

2.14

1.86

0.0024

MAP-8852135

Protein ubiquitination

2 of 88

2.13

1.85

0.0024

MAP-5668541

TNFR2 non-canonical NF-kB pathway

2 of 92

2.11

1.85

0.0024

MAP-176814

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

2 of 88

2.13

1.85

0.0024

MAP-176409

APC/C:Cdc20 mediated degradation of mitotic proteins

2 of 88

2.13

1.85

0.0024

MAP-1168372

Downstream signaling events of B Cell Receptor (BCR)

2 of 90

2.12

1.85

0.0024

MAP-9663891

Selective autophagy

2 of 93

2.1

1.84

0.0024

MAP-8878166

Transcriptional regulation by RUNX2

2 of 95

2.09

1.84

0.0024

MAP-8878159

Transcriptional regulation by RUNX3

2 of 97

2.09

1.84

0.0024

MAP-5632684

Hedgehog on state

2 of 96

2.09

1.84

0.0024

MAP-195253

Degradation of beta-catenin by the destruction complex

2 of 93

2.1

1.84

0.0024

MAP-6781827

Transcription-Coupled Nucleotide Excision Repair (TC-NER)

2 of 98

2.08

1.83

0.0024

MAP-453276

Regulation of mitotic cell cycle

2 of 101

2.07

1.83

0.0024

MAP-174824

Plasma lipoprotein assembly, remodeling, and clearance

2 of 100

2.07

1.83

0.0024

MAP-174143

APC/C-mediated degradation of cell cycle proteins

2 of 101

2.07

1.83

0.0024

MAP-9755511

KEAP1-NFE2L2 pathway

2 of 103

2.06

1.82

0.0024

MAP-9033241

Peroxisomal protein import

2 of 105

2.05

1.82

0.0024

MAP-8948751

Regulation of PTEN stability and activity

2 of 105

2.05

1.82

0.0024

MAP-69052

Switching of origins to a post-replicative state

2 of 103

2.06

1.82

0.0024

MAP-5696399

Global Genome Nucleotide Excision Repair (GG-NER)

2 of 107

2.04

1.82

0.0024

MAP-4086400

PCP/CE pathway

2 of 107

2.04

1.82

0.0024

MAP-917937

Iron uptake and transport

2 of 108

2.04

1.81

0.0024

MAP-5607764

CLEC7A (Dectin-1) signaling

2 of 111

2.03

1.81

0.0024

MAP-2559582

Senescence-Associated Secretory Phenotype (SASP)

2 of 112

2.02

1.81

0.0024

MAP-193704

p75 NTR receptor-mediated signalling

2 of 108

2.04

1.81

0.0024

MAP-190236

Signaling by FGFR

2 of 109

2.03

1.81

0.0024

MAP-170834

Signaling by TGF-beta Receptor Complex

2 of 112

2.02

1.81

0.0024

MAP-9758274

Regulation of NF-kappa B signaling

2 of 119

2.0

1.79

0.0024

MAP-5689901

Metalloprotease DUBs

2 of 120

1.99

1.79

0.0024

MAP-5689603

UCH proteinases

2 of 122

1.99

1.79

0.0024

MAP-450531

Regulation of mRNA stability by proteins that bind AU-rich elements

2 of 119

2.0

1.79

0.0024

MAP-382556

ABC-family proteins mediated transport

2 of 120

1.99

1.79

0.0024

MAP-2565942

Regulation of PLK1 Activity at G2/M Transition

2 of 119

2.0

1.79

0.0024

MAP-69206

G1/S Transition

2 of 130

1.96

1.77

0.0024

MAP-5610787

Hedgehog off state

2 of 132

1.95

1.77

0.0024

MAP-68867

Assembly of the pre-replicative complex

2 of 138

1.93

1.76

0.0024

MAP-69239

Synthesis of DNA

2 of 142

1.92

1.75

0.0024

MAP-6804756

Regulation of TP53 Activity through Phosphorylation

2 of 140

1.93

1.75

0.0024

MAP-5621481

C-type lectin receptors (CLRs)

2 of 142

1.92

1.75

0.0024

MAP-445989

TAK1-dependent IKK and NF-kappa-B activation

2 of 141

1.92

1.75

0.0024

MAP-5696398

Nucleotide Excision Repair

2 of 146

1.91

1.74

0.0024

MAP-5693565

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

2 of 147

1.9

1.74

0.0024

MAP-9006936

Signaling by TGFB family members

2 of 153

1.89

1.73

0.0024

MAP-5693606

DNA Double Strand Break Response

2 of 151

1.89

1.73

0.0024

MAP-69002

DNA Replication Pre-Initiation

2 of 159

1.87

1.71

0.0025

MAP-9020702

Interleukin-1 signaling

2 of 162

1.86

1.69

0.0026

MAP-2871837

FCERI mediated NF-kB activation

2 of 163

1.86

1.69

0.0026

MAP-453279

Mitotic G1 phase and G1/S transition

2 of 165

1.85

1.68

0.0027

MAP-9612973

Autophagy

2 of 170

1.84

1.66

0.0028

MAP-1632852

Macroautophagy

2 of 170

1.84

1.66

0.0028

MAP-8856825

Cargo recognition for clathrin-mediated endocytosis

2 of 178

1.82

1.63

0.0031

MAP-6807070

PTEN Regulation

2 of 179

1.82

1.63

0.0031

MAP-446652

Interleukin-1 family signaling

2 of 178

1.82

1.63

0.0031

MAP-3858494

Beta-catenin independent WNT signaling

2 of 180

1.82

1.62

0.0031

MAP-5358351

Signaling by Hedgehog

2 of 185

1.8

1.61

0.0032

MAP-73887

Death Receptor Signaling

2 of 187

1.8

1.6

0.0033

MAP-69242

S Phase

2 of 191

1.79

1.59

0.0034

MAP-5357801

Programmed Cell Death

2 of 190

1.79

1.59

0.0034

MAP-69306

DNA Replication

2 of 195

1.78

1.57

0.0035

MAP-9609507

Protein localization

2 of 200

1.77

1.55

0.0037

MAP-168164

Toll Like Receptor 3 (TLR3) Cascade

2 of 200

1.77

1.55

0.0037

MAP-975871

MyD88 cascade initiated on plasma membrane

2 of 206

1.76

1.54

0.0038

MAP-975155

MyD88 dependent cascade initiated on endosome

2 of 204

1.76

1.54

0.0038

MAP-975138

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

2 of 204

1.76

1.54

0.0038

MAP-2559583

Cellular Senescence

2 of 207

1.76

1.54

0.0038

MAP-181438

Toll Like Receptor 2 (TLR2) Cascade

2 of 207

1.76

1.54

0.0038

MAP-168188

Toll Like Receptor TLR6:TLR2 Cascade

2 of 207

1.76

1.54

0.0038

MAP-168181

Toll Like Receptor 7/8 (TLR7/8) Cascade

2 of 204

1.76

1.54

0.0038

MAP-168179

Toll Like Receptor TLR1:TLR2 Cascade

2 of 207

1.76

1.54

0.0038

MAP-168176

Toll Like Receptor 5 (TLR5) Cascade

2 of 206

1.76

1.54

0.0038

MAP-168142

Toll Like Receptor 10 (TLR10) Cascade

2 of 207

1.76

1.54

0.0038

MAP-168138

Toll Like Receptor 9 (TLR9) Cascade

2 of 205

1.76

1.54

0.0038

MAP-166058

MyD88:MAL(TIRAP) cascade initiated on plasma membrane

2 of 207

1.76

1.54

0.0038

MAP-937061

TRIF(TICAM1)-mediated TLR4 signaling

2 of 211

1.75

1.53

0.0038

MAP-166166

MyD88-independent TLR4 cascade

2 of 211

1.75

1.53

0.0038

MAP-5693567

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

2 of 215

1.74

1.52

0.0039

MAP-5687128

MAPK6/MAPK4 signaling

2 of 216

1.74

1.52

0.0039

MAP-8878171

Transcriptional regulation by RUNX1

2 of 221

1.73

1.5

0.0041

MAP-69275

G2/M Transition

2 of 222

1.73

1.5

0.0041

MAP-5693538

Homology Directed Repair

2 of 223

1.72

1.5

0.0041

MAP-166016

Toll Like Receptor 4 (TLR4) Cascade

2 of 222

1.73

1.5

0.0041

MAP-9711123

Cellular response to chemical stress

2 of 225

1.72

1.49

0.0042

MAP-453274

Mitotic G2-G2/M phases

2 of 225

1.72

1.49

0.0042

MAP-2467813

Separation of Sister Chromatids

2 of 228

1.71

1.49

0.0042

MAP-5633007

Regulation of TP53 Activity

2 of 234

1.7

1.46

0.0045

MAP-8856828

Clathrin-mediated endocytosis

2 of 239

1.69

1.45

0.0046

MAP-5689880

Ub-specific processing proteases

2 of 247

1.68

1.43

0.0049

MAP-168898

Toll-like Receptor Cascades

2 of 254

1.67

1.41

0.0052

MAP-983705

Signaling by the B Cell Receptor (BCR)

2 of 257

1.66

1.4

0.0053

MAP-69481

G2/M Checkpoints

2 of 260

1.66

1.4

0.0053

MAP-5693532

DNA Double-Strand Break Repair

2 of 258

1.66

1.4

0.0053

MAP-201681

TCF dependent signaling in response to WNT

2 of 258

1.66

1.4

0.0053

MAP-2454202

Fc epsilon receptor (FCERI) signaling

2 of 267

1.65

1.38

0.0056

MAP-68882

Mitotic Anaphase

2 of 292

1.61

1.32

0.0066

MAP-2555396

Mitotic Metaphase and Anaphase

2 of 295

1.6

1.31

0.0067

MAP-1257604

PIP3 activates AKT signaling

2 of 350

1.53

1.19

0.0094

MAP-8951664

Neddylation

2 of 369

1.5

1.16

0.0104

MAP-5673001

RAF/MAP kinase cascade

2 of 372

1.5

1.15

0.0105

MAP-5684996

MAPK1/MAPK3 signaling

2 of 379

1.49

1.14

0.0108

MAP-9006925

Intracellular signaling by second messengers

2 of 398

1.47

1.11

0.0119

MAP-69620

Cell Cycle Checkpoints

2 of 413

1.46

1.09

0.0127

MAP-195721

Signaling by WNT

2 of 413

1.46

1.09

0.0127

MAP-5688426

Deubiquitination

2 of 433

1.44

1.06

0.0138

MAP-446203

Asparagine N-linked glycosylation

2 of 433

1.44

1.06

0.0138

MAP-9675108

Nervous system development

2 of 479

1.39

1.0

0.0167

MAP-3700989

Transcriptional Regulation by TP53

2 of 484

1.39

0.99

0.0170

MAP-73894

DNA Repair

2 of 490

1.38

0.98

0.0174

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

2 of 510

1.36

0.96

0.0187

MAP-68886

M Phase

2 of 516

1.36

0.95

0.0191

MAP-5683057

MAPK family signaling cascades

2 of 548

1.33

0.92

0.0214

MAP-449147

Signaling by Interleukins

2 of 556

1.33

0.91

0.0219

MAP-983169

Class I MHC mediated antigen processing & presentation

2 of 595

1.3

0.87

0.0249

MAP-9006934

Signaling by Receptor Tyrosine Kinases

2 of 614

1.28

0.85

0.0264

MAP-69278

Cell Cycle, Mitotic

2 of 696

1.23

0.78

0.0336

MAP-1266738

Developmental Biology

2 of 780

1.18

0.72

0.0418

MAP-1280215

Cytokine Signaling in Immune system

2 of 783

1.18

0.72

0.0419

MAP-2262752

Cellular responses to stress

2 of 820

1.16

0.69

0.0457

MAP-8953897

Cellular responses to stimuli

2 of 833

1.15

0.69

0.0470

(more ...)

(less ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019956

Ubiquitin domain

2 of 14

2.93

1.34

0.0185

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00213

Ubiquitin homologues

2 of 39

2.48

1.41

0.0138

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYB5R4	W5M3R0_LEPOC	ENSLOCP00000020462	ENSLOCP00000003018	Cytochrome b5 reductase 4.	MFS domain-containing protein.	0.760
CYB5R4	W5MTQ7_LEPOC	ENSLOCP00000020462	ENSLOCP00000011766	Cytochrome b5 reductase 4.	NME/NM23 family member 8; Belongs to the NDK family.	0.850
CYB5R4	W5N0B4_LEPOC	ENSLOCP00000020462	ENSLOCP00000014073	Cytochrome b5 reductase 4.	Uncharacterized protein; Belongs to the NDK family.	0.850
CYB5R4	W5NJ40_LEPOC	ENSLOCP00000020462	ENSLOCP00000020649	Cytochrome b5 reductase 4.	Epoxide hydrolase 2, cytoplasmic.	0.816
CYB5R4	gapdh	ENSLOCP00000020462	ENSLOCP00000008412	Cytochrome b5 reductase 4.	Glyceraldehyde-3-phosphate dehydrogenase.	0.559
CYB5R4	gapdhs	ENSLOCP00000020462	ENSLOCP00000004185	Cytochrome b5 reductase 4.	Glyceraldehyde-3-phosphate dehydrogenase.	0.559
W5M3R0_LEPOC	CYB5R4	ENSLOCP00000003018	ENSLOCP00000020462	MFS domain-containing protein.	Cytochrome b5 reductase 4.	0.760
W5M3R0_LEPOC	W5MTQ7_LEPOC	ENSLOCP00000003018	ENSLOCP00000011766	MFS domain-containing protein.	NME/NM23 family member 8; Belongs to the NDK family.	0.471
W5M3R0_LEPOC	W5N0B4_LEPOC	ENSLOCP00000003018	ENSLOCP00000014073	MFS domain-containing protein.	Uncharacterized protein; Belongs to the NDK family.	0.471
W5M3R0_LEPOC	W5NJ40_LEPOC	ENSLOCP00000003018	ENSLOCP00000020649	MFS domain-containing protein.	Epoxide hydrolase 2, cytoplasmic.	0.560
W5M3R0_LEPOC	agxt	ENSLOCP00000003018	ENSLOCP00000007880	MFS domain-containing protein.	Serine--pyruvate aminotransferase.	0.449
W5M3R0_LEPOC	cstf3	ENSLOCP00000003018	ENSLOCP00000005276	MFS domain-containing protein.	Cleavage stimulation factor, 3' pre-RNA, subunit 3.	0.517
W5M3R0_LEPOC	gapdh	ENSLOCP00000003018	ENSLOCP00000008412	MFS domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.544
W5M3R0_LEPOC	gapdhs	ENSLOCP00000003018	ENSLOCP00000004185	MFS domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.544
W5M3R0_LEPOC	tk1	ENSLOCP00000003018	ENSLOCP00000015599	MFS domain-containing protein.	Thymidine kinase.	0.525
W5M3R0_LEPOC	tyms	ENSLOCP00000003018	ENSLOCP00000013490	MFS domain-containing protein.	Thymidylate synthetase.	0.506
W5MTQ7_LEPOC	CYB5R4	ENSLOCP00000011766	ENSLOCP00000020462	NME/NM23 family member 8; Belongs to the NDK family.	Cytochrome b5 reductase 4.	0.850
W5MTQ7_LEPOC	W5M3R0_LEPOC	ENSLOCP00000011766	ENSLOCP00000003018	NME/NM23 family member 8; Belongs to the NDK family.	MFS domain-containing protein.	0.471
W5MTQ7_LEPOC	W5N0B4_LEPOC	ENSLOCP00000011766	ENSLOCP00000014073	NME/NM23 family member 8; Belongs to the NDK family.	Uncharacterized protein; Belongs to the NDK family.	0.919
W5MTQ7_LEPOC	gapdh	ENSLOCP00000011766	ENSLOCP00000008412	NME/NM23 family member 8; Belongs to the NDK family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.710

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