STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5M429_LEPOCToll-interleukin 1 receptor (TIR) domain containing adaptor protein. (216 aa)    
Predicted Functional Partners:
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
    
0.989
W5M7V9_LEPOC
Uncharacterized protein.
   
 0.987
W5LYQ5_LEPOC
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.980
irak4
Interleukin 1 receptor associated kinase 4.
    
 0.969
W5NBX6_LEPOC
Interleukin-1 receptor-associated kinase 1.
   
 0.950
W5NNW2_LEPOC
Toll-like receptor.
   
0.943
W5MIP8_LEPOC
Toll interacting protein.
     
 0.894
fadd
Fas associated via death domain.
    
 0.879
TLR5
Toll like receptor 5; Belongs to the Toll-like receptor family.
   
 0.812
LOC102687114
Toll-like receptor 18; Belongs to the Toll-like receptor family.
   
 0.803
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.