STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5M443_LEPOCReplication timing regulatory factor 1. (2179 aa)    
Predicted Functional Partners:
tp53bp1
Tumor protein p53 binding protein, 1.
    
 0.829
W5LZK6_LEPOC
Non-specific serine/threonine protein kinase.
   
 
 0.818
paxip1
PAX interacting (with transcription-activation domain) protein 1.
   
 0.809
W5NDJ0_LEPOC
ADP-ribosylation factor-like 1.
    
  0.739
bard1
BRCA1 associated RING domain 1.
    
 0.728
W5N007_LEPOC
SANT domain-containing protein.
   
    0.705
mre11
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
   
 0.704
W5N048_LEPOC
Uncharacterized protein.
   
 0.701
LOC102699233
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.696
babam2
BRISC and BRCA1 A complex member 2.
    
  0.690
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.