W5M5L2_LEPOC protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

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second shell of interactors

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

W5M5L2_LEPOC

G_PROTEIN_RECEP_F3_4 domain-containing protein. (858 aa)

Predicted Functional Partners:

W5M6P3_LEPOC

0.594

GABBR2

0.467

homer2

0.454

ptk7

0.454

TRIO

0.441

W5MDZ1_LEPOC

0.441

ARHGEF25

0.441

homer3

0.432

homer1

0.432

camk2g

0.432

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF25	W5M5L2_LEPOC	ENSLOCP00000009210	ENSLOCP00000003670	DH domain-containing protein.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.441
ARHGEF25	ptk7	ENSLOCP00000009210	ENSLOCP00000019563	DH domain-containing protein.	Protein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.482
GABBR2	W5M5L2_LEPOC	ENSLOCP00000008700	ENSLOCP00000003670	Gamma-aminobutyric acid (GABA) B receptor, 2.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.467
TRIO	W5M5L2_LEPOC	ENSLOCP00000000851	ENSLOCP00000003670	Trio Rho guanine nucleotide exchange factor a.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.441
TRIO	ptk7	ENSLOCP00000000851	ENSLOCP00000019563	Trio Rho guanine nucleotide exchange factor a.	Protein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.482
W5M5L2_LEPOC	ARHGEF25	ENSLOCP00000003670	ENSLOCP00000009210	G_PROTEIN_RECEP_F3_4 domain-containing protein.	DH domain-containing protein.	0.441
W5M5L2_LEPOC	GABBR2	ENSLOCP00000003670	ENSLOCP00000008700	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Gamma-aminobutyric acid (GABA) B receptor, 2.	0.467
W5M5L2_LEPOC	TRIO	ENSLOCP00000003670	ENSLOCP00000000851	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Trio Rho guanine nucleotide exchange factor a.	0.441
W5M5L2_LEPOC	W5M6P3_LEPOC	ENSLOCP00000003670	ENSLOCP00000004051	G_PROTEIN_RECEP_F3_4 domain-containing protein.	WD repeat domain 90.	0.594
W5M5L2_LEPOC	W5MDZ1_LEPOC	ENSLOCP00000003670	ENSLOCP00000006600	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Kalirin RhoGEF kinase a.	0.441
W5M5L2_LEPOC	camk2g	ENSLOCP00000003670	ENSLOCP00000015478	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1.	0.432
W5M5L2_LEPOC	homer1	ENSLOCP00000003670	ENSLOCP00000007170	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Homer scaffold protein 1b.	0.432
W5M5L2_LEPOC	homer2	ENSLOCP00000003670	ENSLOCP00000015944	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Homer scaffold protein 2.	0.454
W5M5L2_LEPOC	homer3	ENSLOCP00000003670	ENSLOCP00000002497	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Homer scaffold protein 3b.	0.432
W5M5L2_LEPOC	ptk7	ENSLOCP00000003670	ENSLOCP00000019563	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Protein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.454
W5M6P3_LEPOC	W5M5L2_LEPOC	ENSLOCP00000004051	ENSLOCP00000003670	WD repeat domain 90.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.594
W5MDZ1_LEPOC	W5M5L2_LEPOC	ENSLOCP00000006600	ENSLOCP00000003670	Kalirin RhoGEF kinase a.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.441
W5MDZ1_LEPOC	ptk7	ENSLOCP00000006600	ENSLOCP00000019563	Kalirin RhoGEF kinase a.	Protein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.482
camk2g	W5M5L2_LEPOC	ENSLOCP00000015478	ENSLOCP00000003670	Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.432
homer1	W5M5L2_LEPOC	ENSLOCP00000007170	ENSLOCP00000003670	Homer scaffold protein 1b.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.432

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006796

Phosphate-containing compound metabolic process

8 of 941

1.07

1.08

7.32e-05

GO:0006470

Protein dephosphorylation

3 of 67

1.8

1.07

0.0074

GO:0036211

Protein modification process

7 of 1176

0.92

0.7

0.0034

GO:0006468

Protein phosphorylation

4 of 415

1.13

0.57

0.0437

GO:1901564

Organonitrogen compound metabolic process

8 of 2532

0.64

0.41

0.0241

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017018

Myosin phosphatase activity

3 of 45

1.97

1.16

0.0058

GO:0140096

Catalytic activity, acting on a protein

7 of 1272

0.89

0.64

0.0058

GO:0004672

Protein kinase activity

4 of 415

1.13

0.59

0.0390

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:556

Mixed, incl. GDP metabolic process, and Signaling receptor complex adaptor activity

3 of 5

2.92

2.59

1.88e-05

CL:1988

Mixed, incl. Serine/Threonine Kinase AGC, catalytic domain, and PI3K Cascade

4 of 32

2.24

2.42

1.88e-05

CL:1900

Mixed, incl. Serine/threonine-protein kinase, and MAPK cascade

5 of 137

1.71

2.01

2.10e-05

CL:1990

Mixed, incl. Serine/Threonine Kinase AGC, catalytic domain, and PI3K Cascade

3 of 26

2.21

1.84

0.00029

CL:13390

Cyclic nucleotide-dependent protein kinase activity, and PPM-type phosphatase, divalent cation binding

2 of 6

2.67

1.43

0.0025

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000719

Protein kinase domain

8 of 394

1.45

2.15

1.07e-07

IPR011009

Protein kinase-like domain superfamily

8 of 431

1.41

2.07

1.08e-07

IPR036457

PPM-type phosphatase-like domain superfamily

3 of 30

2.14

1.45

0.0017

IPR001932

PPM-type phosphatase-like domain

3 of 30

2.14

1.45

0.0017

IPR000222

PPM-type phosphatase, divalent cation binding

2 of 12

2.37

0.84

0.0285

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00331

Sigma factor PP2C-like phosphatases

2 of 22

2.1

0.73

0.0449

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