STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (228 aa)    
Predicted Functional Partners:
hmgcr
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.885
chaf1b
Chromatin assembly factor 1, subunit B.
    
 
 0.865
W5NEJ3_LEPOC
Origin recognition complex, subunit 5.
    
   0.780
W5NJX2_LEPOC
Origin recognition complex, subunit 3.
    
   0.780
W5LWR5_LEPOC
SSD domain-containing protein.
   
 0.733
SCAP
SREBF chaperone.
   
 0.733
W5M9W6_LEPOC
WD_REPEATS_REGION domain-containing protein.
   
 0.733
W5M9Y5_LEPOC
SSD domain-containing protein.
   
 0.733
npc1
Niemann-Pick disease, type C1.
   
 0.682
NPC1L1
NPC1 like intracellular cholesterol transporter 1.
   
 0.682
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.