SCTR protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

SCTR

Secretin receptor; Belongs to the G-protein coupled receptor 2 family. (386 aa)

Predicted Functional Partners:

pthlh

0.747

gnal

0.707

W5NMQ4_LEPOC

0.707

crh

0.706

W5NN84_LEPOC

0.706

W5MYS6_LEPOC

0.666

pth2

0.624

calcb

0.612

W5LZZ8_LEPOC

0.610

vip

0.610

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SCTR	W5LZZ8_LEPOC	ENSLOCP00000003886	ENSLOCP00000001705	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	GLUCAGON domain-containing protein.	0.610
SCTR	W5MYS6_LEPOC	ENSLOCP00000003886	ENSLOCP00000013535	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	Adenylate cyclase activating polypeptide 1a.	0.666
SCTR	W5NMQ4_LEPOC	ENSLOCP00000003886	ENSLOCP00000021913	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.707
SCTR	W5NN84_LEPOC	ENSLOCP00000003886	ENSLOCP00000022093	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	Urotensin 1.	0.706
SCTR	calcb	ENSLOCP00000003886	ENSLOCP00000003679	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	Calcitonin/calcitonin-related polypeptide, alpha.	0.612
SCTR	crh	ENSLOCP00000003886	ENSLOCP00000021917	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	Corticotropin releasing hormone a.	0.706
SCTR	gnal	ENSLOCP00000003886	ENSLOCP00000002598	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.707
SCTR	pth2	ENSLOCP00000003886	ENSLOCP00000017398	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	Parathyroid hormone 2.	0.624
SCTR	pthlh	ENSLOCP00000003886	ENSLOCP00000020387	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	Parathyroid hormone-like hormone a.	0.747
SCTR	vip	ENSLOCP00000003886	ENSLOCP00000019083	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	Vasoactive intestinal peptide.	0.610
W5LZZ8_LEPOC	SCTR	ENSLOCP00000001705	ENSLOCP00000003886	GLUCAGON domain-containing protein.	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	0.610
W5LZZ8_LEPOC	W5NMQ4_LEPOC	ENSLOCP00000001705	ENSLOCP00000021913	GLUCAGON domain-containing protein.	Uncharacterized protein.	0.727
W5LZZ8_LEPOC	calcb	ENSLOCP00000001705	ENSLOCP00000003679	GLUCAGON domain-containing protein.	Calcitonin/calcitonin-related polypeptide, alpha.	0.518
W5LZZ8_LEPOC	gnal	ENSLOCP00000001705	ENSLOCP00000002598	GLUCAGON domain-containing protein.	Uncharacterized protein.	0.727
W5MYS6_LEPOC	SCTR	ENSLOCP00000013535	ENSLOCP00000003886	Adenylate cyclase activating polypeptide 1a.	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	0.666
W5MYS6_LEPOC	W5NMQ4_LEPOC	ENSLOCP00000013535	ENSLOCP00000021913	Adenylate cyclase activating polypeptide 1a.	Uncharacterized protein.	0.572
W5MYS6_LEPOC	W5NN84_LEPOC	ENSLOCP00000013535	ENSLOCP00000022093	Adenylate cyclase activating polypeptide 1a.	Urotensin 1.	0.400
W5MYS6_LEPOC	crh	ENSLOCP00000013535	ENSLOCP00000021917	Adenylate cyclase activating polypeptide 1a.	Corticotropin releasing hormone a.	0.476
W5MYS6_LEPOC	gnal	ENSLOCP00000013535	ENSLOCP00000002598	Adenylate cyclase activating polypeptide 1a.	Uncharacterized protein.	0.583
W5NMQ4_LEPOC	SCTR	ENSLOCP00000021913	ENSLOCP00000003886	Uncharacterized protein.	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	0.707

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.889

expected number of edges:

11

PPI enrichment p-value:

2.4e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006865

Amino acid transport

4 of 29

1.51

0.97

0.0077

GO:0048473

D-methionine transport

2 of 2

2.37

0.78

0.0369

GO:0006810

Transport

7 of 351

0.67

0.4

0.0369

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4359

NIL domain, and NlpA lipoprotein

6 of 6

2.37

4.81

1.57e-10

CL:4333

Mixed, incl. UROD/MetE-like superfamily, and NIL domain

8 of 19

1.99

4.6

4.49e-12

CL:4285

Quorum sensing, and UROD/MetE-like superfamily

9 of 43

1.69

3.6

4.49e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cst02010

ABC transporters

6 of 91

1.19

1.21

9.05e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0029

Amino-acid transport

2 of 3

2.19

0.81

0.0321

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03180

NlpA lipoprotein

2 of 2

2.37

0.76

0.0410

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00930

This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins. This domain is likely to act as a substrate binding domain. The domain has been named after a ...

2 of 2

2.37

1.07

0.0106

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