tpmt protein (Lepisosteus oculatus) - STRING interaction network

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Score

tpmt

Thiopurine S-methyltransferase, tandem duplicate 1. (244 aa)

Predicted Functional Partners:

itpa

0.918

IMPDH

0.888

impdh1

0.888

gmps

0.877

LOC102696292

0.872

LOC102696574

0.872

aarsd1

0.800

W5NAQ4_LEPOC

0.753

CYB5R4

0.723

W5M6I3_LEPOC

0.722

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYB5R4	gmps	ENSLOCP00000020462	ENSLOCP00000003762	Cytochrome b5 reductase 4.	Guanine monophosphate synthase.	0.734
CYB5R4	tpmt	ENSLOCP00000020462	ENSLOCP00000004096	Cytochrome b5 reductase 4.	Thiopurine S-methyltransferase, tandem duplicate 1.	0.723
IMPDH	LOC102696292	ENSLOCP00000017723	ENSLOCP00000004635	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.884
IMPDH	LOC102696574	ENSLOCP00000017723	ENSLOCP00000018568	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Hypoxanthine phosphoribosyltransferase 1.	0.884
IMPDH	W5M6I3_LEPOC	ENSLOCP00000017723	ENSLOCP00000003991	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Phosphoribosyl transferase domain containing 1.	0.626
IMPDH	gmps	ENSLOCP00000017723	ENSLOCP00000003762	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Guanine monophosphate synthase.	0.987
IMPDH	impdh1	ENSLOCP00000017723	ENSLOCP00000019135	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.858
IMPDH	itpa	ENSLOCP00000017723	ENSLOCP00000012775	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.919
IMPDH	tpmt	ENSLOCP00000017723	ENSLOCP00000004096	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Thiopurine S-methyltransferase, tandem duplicate 1.	0.888
LOC102696292	IMPDH	ENSLOCP00000004635	ENSLOCP00000017723	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.884
LOC102696292	LOC102696574	ENSLOCP00000004635	ENSLOCP00000018568	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Hypoxanthine phosphoribosyltransferase 1.	0.858
LOC102696292	W5NAQ4_LEPOC	ENSLOCP00000004635	ENSLOCP00000017713	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	DALR anticodon binding domain containing 3.	0.598
LOC102696292	gmps	ENSLOCP00000004635	ENSLOCP00000003762	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Guanine monophosphate synthase.	0.922
LOC102696292	impdh1	ENSLOCP00000004635	ENSLOCP00000019135	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.884
LOC102696292	itpa	ENSLOCP00000004635	ENSLOCP00000012775	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.880
LOC102696292	tpmt	ENSLOCP00000004635	ENSLOCP00000004096	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Thiopurine S-methyltransferase, tandem duplicate 1.	0.872
LOC102696574	IMPDH	ENSLOCP00000018568	ENSLOCP00000017723	Hypoxanthine phosphoribosyltransferase 1.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.884
LOC102696574	LOC102696292	ENSLOCP00000018568	ENSLOCP00000004635	Hypoxanthine phosphoribosyltransferase 1.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.858
LOC102696574	W5NAQ4_LEPOC	ENSLOCP00000018568	ENSLOCP00000017713	Hypoxanthine phosphoribosyltransferase 1.	DALR anticodon binding domain containing 3.	0.598
LOC102696574	gmps	ENSLOCP00000018568	ENSLOCP00000003762	Hypoxanthine phosphoribosyltransferase 1.	Guanine monophosphate synthase.	0.922