STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mapk8Mitogen-activated protein kinase. (384 aa)    
Predicted Functional Partners:
map2k4
Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.
  
0.988
LOC102691138
Mitogen-activated protein kinase.
  
 
0.982
jun
Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.
    
 0.971
LOC102689161
JunE proto-oncogene, AP-1 transcription factor subunit.
    
 0.971
nfatc3
Nuclear factor of activated T cells 3a.
    
  0.967
map2k7
Mitogen-activated protein kinase kinase 7.
    
0.964
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.961
map3k1
Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase.
    
0.941
jund
BZIP domain-containing protein.
    
 0.939
junb
JunB proto-oncogene, AP-1 transcription factor subunit a.
    
 0.934
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.