STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mvkMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (398 aa)    
Predicted Functional Partners:
W5LZA1_LEPOC
Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.
 
 
 0.997
hmgcr
3-hydroxy-3-methylglutaryl coenzyme A reductase.
  
 0.966
hmgcs1
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
  
 
 0.966
miox
Myo-inositol oxygenase.
   
 
 0.928
hmgcl
3-hydroxy-3-methylglutaryl-CoA lyase.
    
 0.917
hmgcll1
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1.
    
 0.917
sh3yl1
SH3 and SYLF domain containing 1.
    
   0.916
cth
Cystathionase (cystathionine gamma-lyase), like.
 
 
    0.900
cs
Citrate synthase; Belongs to the citrate synthase family.
    
 0.883
oxct1
Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
     
 0.871
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
Server load: low (22%) [HD]