node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
W5LZA1_LEPOC | hmgcr | ENSLOCP00000001458 | ENSLOCP00000006557 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.959 |
W5LZA1_LEPOC | hmgcs1 | ENSLOCP00000001458 | ENSLOCP00000013447 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.896 |
W5LZA1_LEPOC | mvk | ENSLOCP00000001458 | ENSLOCP00000005162 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.997 |
cs | hmgcl | ENSLOCP00000005579 | ENSLOCP00000002075 | Citrate synthase; Belongs to the citrate synthase family. | 3-hydroxy-3-methylglutaryl-CoA lyase. | 0.937 |
cs | hmgcll1 | ENSLOCP00000005579 | ENSLOCP00000020908 | Citrate synthase; Belongs to the citrate synthase family. | 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. | 0.937 |
cs | hmgcs1 | ENSLOCP00000005579 | ENSLOCP00000013447 | Citrate synthase; Belongs to the citrate synthase family. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.901 |
cs | mvk | ENSLOCP00000005579 | ENSLOCP00000005162 | Citrate synthase; Belongs to the citrate synthase family. | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.883 |
cs | oxct1 | ENSLOCP00000005579 | ENSLOCP00000009727 | Citrate synthase; Belongs to the citrate synthase family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.725 |
cth | mvk | ENSLOCP00000012265 | ENSLOCP00000005162 | Cystathionase (cystathionine gamma-lyase), like. | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.900 |
hmgcl | cs | ENSLOCP00000002075 | ENSLOCP00000005579 | 3-hydroxy-3-methylglutaryl-CoA lyase. | Citrate synthase; Belongs to the citrate synthase family. | 0.937 |
hmgcl | hmgcll1 | ENSLOCP00000002075 | ENSLOCP00000020908 | 3-hydroxy-3-methylglutaryl-CoA lyase. | 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. | 0.858 |
hmgcl | hmgcr | ENSLOCP00000002075 | ENSLOCP00000006557 | 3-hydroxy-3-methylglutaryl-CoA lyase. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.903 |
hmgcl | hmgcs1 | ENSLOCP00000002075 | ENSLOCP00000013447 | 3-hydroxy-3-methylglutaryl-CoA lyase. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.922 |
hmgcl | mvk | ENSLOCP00000002075 | ENSLOCP00000005162 | 3-hydroxy-3-methylglutaryl-CoA lyase. | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.917 |
hmgcl | oxct1 | ENSLOCP00000002075 | ENSLOCP00000009727 | 3-hydroxy-3-methylglutaryl-CoA lyase. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.948 |
hmgcll1 | cs | ENSLOCP00000020908 | ENSLOCP00000005579 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. | Citrate synthase; Belongs to the citrate synthase family. | 0.937 |
hmgcll1 | hmgcl | ENSLOCP00000020908 | ENSLOCP00000002075 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. | 3-hydroxy-3-methylglutaryl-CoA lyase. | 0.858 |
hmgcll1 | hmgcr | ENSLOCP00000020908 | ENSLOCP00000006557 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. | 3-hydroxy-3-methylglutaryl coenzyme A reductase. | 0.894 |
hmgcll1 | hmgcs1 | ENSLOCP00000020908 | ENSLOCP00000013447 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.922 |
hmgcll1 | mvk | ENSLOCP00000020908 | ENSLOCP00000005162 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.917 |