STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hipk3Homeodomain interacting protein kinase 3b. (1255 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.938
RASSF5
Ras association domain family member 5.
    
  0.876
W5MWY2_LEPOC
Homeodomain interacting protein kinase 1a.
  
  
 
0.830
dcaf7
Ddb1 and cul4 associated factor 7.
   
 
 0.770
HIPK4
Homeodomain interacting protein kinase 4; Belongs to the protein kinase superfamily.
  
  
 
0.695
hipk2
Homeodomain interacting protein kinase 2.
  
  
 
0.694
pin1
Peptidyl-prolyl cis-trans isomerase.
    
 0.688
W5NBX2_LEPOC
Methyl CpG binding protein 2.
    
 0.642
sumo1
Small ubiquitin-related modifier.
    
 0.633
cbfb
Core-binding factor subunit beta.
     
 0.626
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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