STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5MA58_LEPOCNGFI-A binding protein 2 (EGR1 binding protein 2). (458 aa)    
Predicted Functional Partners:
egr2
Early growth response 2b.
   
 0.895
egr3
Early growth response 3.
   
 0.772
egr1
Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.
   
 0.765
chd5
Chromodomain helicase DNA binding protein 5.
   
 0.718
W5MDN0_LEPOC
Autoimmune regulator.
   
 0.718
W5ML03_LEPOC
Chromodomain helicase DNA binding protein 4a.
   
 0.718
W5N9B6_LEPOC
Chromodomain helicase DNA binding protein 3.
   
 0.718
W5NJK0_LEPOC
Kruppel-like factor 11a.
    
 0.635
phf21a
PHD finger protein 21Ab.
    
 0.601
phf21b
PHD-type domain-containing protein.
    
 0.601
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.