icmt protein (Lepisosteus oculatus) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

icmt

Protein-S-isoprenylcysteine O-methyltransferase. (301 aa)

Predicted Functional Partners:

W5M0P6_LEPOC

0.946

zmpste24

0.944

nudt12

0.903

rfk

0.900

W5MQY7_LEPOC

0.893

cth

0.862

pudp

0.862

cbs

0.857

mthfr

0.857

LOC102687407

0.842

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102687407	W5M0P6_LEPOC	ENSLOCP00000008522	ENSLOCP00000001953	Si:dkey-193c22.1.	Uncharacterized protein.	0.857
LOC102687407	icmt	ENSLOCP00000008522	ENSLOCP00000005851	Si:dkey-193c22.1.	Protein-S-isoprenylcysteine O-methyltransferase.	0.842
LOC102687407	zmpste24	ENSLOCP00000008522	ENSLOCP00000005215	Si:dkey-193c22.1.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.856
W5M0P6_LEPOC	LOC102687407	ENSLOCP00000001953	ENSLOCP00000008522	Uncharacterized protein.	Si:dkey-193c22.1.	0.857
W5M0P6_LEPOC	W5MQY7_LEPOC	ENSLOCP00000001953	ENSLOCP00000010796	Uncharacterized protein.	OMA1 zinc metallopeptidase.	0.948
W5M0P6_LEPOC	icmt	ENSLOCP00000001953	ENSLOCP00000005851	Uncharacterized protein.	Protein-S-isoprenylcysteine O-methyltransferase.	0.946
W5M0P6_LEPOC	zmpste24	ENSLOCP00000001953	ENSLOCP00000005215	Uncharacterized protein.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.983
W5MQY7_LEPOC	W5M0P6_LEPOC	ENSLOCP00000010796	ENSLOCP00000001953	OMA1 zinc metallopeptidase.	Uncharacterized protein.	0.948
W5MQY7_LEPOC	icmt	ENSLOCP00000010796	ENSLOCP00000005851	OMA1 zinc metallopeptidase.	Protein-S-isoprenylcysteine O-methyltransferase.	0.893
W5MQY7_LEPOC	zmpste24	ENSLOCP00000010796	ENSLOCP00000005215	OMA1 zinc metallopeptidase.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.571
cbs	cth	ENSLOCP00000001396	ENSLOCP00000012265	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Cystathionase (cystathionine gamma-lyase), like.	0.998
cbs	icmt	ENSLOCP00000001396	ENSLOCP00000005851	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Protein-S-isoprenylcysteine O-methyltransferase.	0.857
cbs	mthfr	ENSLOCP00000001396	ENSLOCP00000006784	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.948
cbs	rfk	ENSLOCP00000001396	ENSLOCP00000012004	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Riboflavin kinase.	0.459
cth	cbs	ENSLOCP00000012265	ENSLOCP00000001396	Cystathionase (cystathionine gamma-lyase), like.	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.998
cth	icmt	ENSLOCP00000012265	ENSLOCP00000005851	Cystathionase (cystathionine gamma-lyase), like.	Protein-S-isoprenylcysteine O-methyltransferase.	0.862
cth	mthfr	ENSLOCP00000012265	ENSLOCP00000006784	Cystathionase (cystathionine gamma-lyase), like.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.994
icmt	LOC102687407	ENSLOCP00000005851	ENSLOCP00000008522	Protein-S-isoprenylcysteine O-methyltransferase.	Si:dkey-193c22.1.	0.842
icmt	W5M0P6_LEPOC	ENSLOCP00000005851	ENSLOCP00000001953	Protein-S-isoprenylcysteine O-methyltransferase.	Uncharacterized protein.	0.946
icmt	W5MQY7_LEPOC	ENSLOCP00000005851	ENSLOCP00000010796	Protein-S-isoprenylcysteine O-methyltransferase.	OMA1 zinc metallopeptidase.	0.893

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Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.859

expected number of edges:

10

PPI enrichment p-value:

0.105

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032957

Inositol trisphosphate metabolic process

4 of 5

3.24

4.19

2.40e-08

GO:0070266

Necroptotic process

4 of 13

2.83

3.59

2.27e-07

GO:0006066

Alcohol metabolic process

5 of 291

1.58

1.61

0.00014

GO:0052746

Inositol phosphorylation

2 of 3

3.16

1.54

0.0017

GO:0032958

Inositol phosphate biosynthetic process

2 of 14

2.5

0.97

0.0167

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000825

Inositol tetrakisphosphate 6-kinase activity

4 of 4

3.34

4.61

4.39e-09

GO:0051766

Inositol trisphosphate kinase activity

4 of 9

2.99

4.26

1.49e-08

GO:0003993

Acid phosphatase activity

3 of 7

2.97

2.88

5.66e-06

GO:0102732

myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

GO:0052726

inositol-1,3,4-trisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30075

Acid phosphatase activity, and Alkaline phosphatase activity

6 of 14

2.97

6.68

3.23e-13

CL:30076

Acid phosphatase activity, and Phosphodiesterase I activity

4 of 7

3.1

4.32

1.27e-08

CL:38050

Inositol trisphosphate kinase activity, and Inositol tetrakisphosphate phosphatase activity

4 of 17

2.71

3.62

1.72e-07

CL:38074

Inositol phosphorylation, and Inositol tetrakisphosphate 5-kinase activity

3 of 5

3.12

2.98

3.89e-06

CL:30089

Alkaline phosphatase activity, and Acid phosphatase activity

2 of 7

2.8

1.41

0.0028

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00730

Thiamine metabolism

4 of 21

2.62

3.84

5.24e-08

map00740

Riboflavin metabolism

3 of 19

2.54

2.8

5.30e-06

map00562

Inositol phosphate metabolism

5 of 169

1.81

2.66

5.39e-07

map04070

Phosphatidylinositol signaling system

4 of 181

1.68

1.89

4.16e-05

map01100

Metabolic pathways

11 of 3242

0.87

0.96

5.24e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483249

Inositol phosphate metabolism

5 of 70

2.19

3.28

1.94e-07

MAP-196819

Vitamin B1 (thiamin) metabolism

2 of 5

2.94

1.47

0.0022

MAP-1855191

Synthesis of IPs in the nucleus

2 of 7

2.8

1.41

0.0028

MAP-1855167

Synthesis of pyrophosphates in the cytosol

2 of 10

2.64

1.3

0.0042

MAP-196849

Metabolism of water-soluble vitamins and cofactors

3 of 192

1.53

0.79

0.0228

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00149

Calcineurin-like phosphoesterase

3 of 14

2.67

2.15

0.00011

PF05770

Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain

2 of 2

3.34

1.6

0.0013

PF03770

Inositol polyphosphate kinase

2 of 9

2.69

1.15

0.0081

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