W5MC00_LEPOC protein (Lepisosteus oculatus) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

W5MC00_LEPOC

Melanophilin b. (659 aa)

Predicted Functional Partners:

rab27b

0.863

rab27a

0.863

W5MF00_LEPOC

0.710

W5MG24_LEPOC

0.695

W5N564_LEPOC

0.695

myo5c

0.695

myo5a

0.695

iqcb1

0.411

myo19

0.411

W5MAC8_LEPOC

0.411

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
W5MAC8_LEPOC	W5MC00_LEPOC	ENSLOCP00000005337	ENSLOCP00000005909	Ras association and DIL domains.	Melanophilin b.	0.411
W5MC00_LEPOC	W5MAC8_LEPOC	ENSLOCP00000005909	ENSLOCP00000005337	Melanophilin b.	Ras association and DIL domains.	0.411
W5MC00_LEPOC	W5MF00_LEPOC	ENSLOCP00000005909	ENSLOCP00000006959	Melanophilin b.	Rab interacting lysosomal protein-like 2.	0.710
W5MC00_LEPOC	W5MG24_LEPOC	ENSLOCP00000005909	ENSLOCP00000007333	Melanophilin b.	Methyl-CpG binding domain protein 3b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.695
W5MC00_LEPOC	W5N564_LEPOC	ENSLOCP00000005909	ENSLOCP00000015773	Melanophilin b.	Myosin VB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.695
W5MC00_LEPOC	iqcb1	ENSLOCP00000005909	ENSLOCP00000002605	Melanophilin b.	IQ motif containing B1.	0.411
W5MC00_LEPOC	myo19	ENSLOCP00000005909	ENSLOCP00000003728	Melanophilin b.	Myosin XIX; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.411
W5MC00_LEPOC	myo5a	ENSLOCP00000005909	ENSLOCP00000016516	Melanophilin b.	Myosin VAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.695
W5MC00_LEPOC	myo5c	ENSLOCP00000005909	ENSLOCP00000016476	Melanophilin b.	Myosin VC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.695
W5MC00_LEPOC	rab27a	ENSLOCP00000005909	ENSLOCP00000016582	Melanophilin b.	RAB27A, member RAS oncogene family.	0.863
W5MC00_LEPOC	rab27b	ENSLOCP00000005909	ENSLOCP00000004148	Melanophilin b.	RAB27B, member RAS oncogene family.	0.863
W5MF00_LEPOC	W5MC00_LEPOC	ENSLOCP00000006959	ENSLOCP00000005909	Rab interacting lysosomal protein-like 2.	Melanophilin b.	0.710
W5MF00_LEPOC	W5MG24_LEPOC	ENSLOCP00000006959	ENSLOCP00000007333	Rab interacting lysosomal protein-like 2.	Methyl-CpG binding domain protein 3b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.596
W5MF00_LEPOC	W5N564_LEPOC	ENSLOCP00000006959	ENSLOCP00000015773	Rab interacting lysosomal protein-like 2.	Myosin VB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.596
W5MF00_LEPOC	myo5a	ENSLOCP00000006959	ENSLOCP00000016516	Rab interacting lysosomal protein-like 2.	Myosin VAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.596
W5MF00_LEPOC	myo5c	ENSLOCP00000006959	ENSLOCP00000016476	Rab interacting lysosomal protein-like 2.	Myosin VC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.596
W5MG24_LEPOC	W5MC00_LEPOC	ENSLOCP00000007333	ENSLOCP00000005909	Methyl-CpG binding domain protein 3b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Melanophilin b.	0.695
W5MG24_LEPOC	W5MF00_LEPOC	ENSLOCP00000007333	ENSLOCP00000006959	Methyl-CpG binding domain protein 3b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Rab interacting lysosomal protein-like 2.	0.596
W5MG24_LEPOC	rab27a	ENSLOCP00000007333	ENSLOCP00000016582	Methyl-CpG binding domain protein 3b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	RAB27A, member RAS oncogene family.	0.538
W5MG24_LEPOC	rab27b	ENSLOCP00000007333	ENSLOCP00000004148	Methyl-CpG binding domain protein 3b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	RAB27B, member RAS oncogene family.	0.538

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.766

expected number of edges:

20

PPI enrichment p-value:

0.0814

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016052

Carbohydrate catabolic process

5 of 28

1.91

2.44

5.04e-06

GO:0019310

Inositol catabolic process

2 of 2

2.66

1.07

0.0112

GO:0005975

Carbohydrate metabolic process

6 of 186

1.17

1.04

0.00071

GO:0005996

Monosaccharide metabolic process

3 of 35

1.6

0.94

0.0112

GO:0044282

Small molecule catabolic process

4 of 121

1.18

0.76

0.0121

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1519

0.48

0.36

0.0076

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:963

Mixed, incl. Pentose phosphate pathway, and Glycolytic process

5 of 53

1.64

1.75

7.94e-05

CL:2352

Mixed, incl. AMP metabolic process, and GMP biosynthesis

3 of 11

2.1

1.47

0.0015

CL:1045

Mostly uncharacterized, incl. Carbohydrate kinase PfkB, and UxaA/GarD, SAF domain

3 of 12

2.06

1.46

0.0015

CL:2356

GMP biosynthesis, and De novo AMP biosynthetic process

2 of 5

2.26

0.92

0.0196

CL:974

Glycolysis, and Glyceraldehyde-3-phosphate dehydrogenase, type I

2 of 7

2.12

0.87

0.0240

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00030

Pentose phosphate pathway

5 of 39

1.77

2.4

2.24e-06

map01200

Carbon metabolism

5 of 292

0.9

0.61

0.0099

map01120

Microbial metabolism in diverse environments

6 of 540

0.71

0.47

0.0141

map01100

Metabolic pathways

11 of 1791

0.45

0.38

0.00073

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

9 of 1044

0.6

0.43

0.0071

GOCC:0005622

Intracellular

10 of 1615

0.45

0.33

0.0122

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