surf2 protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

surf2

Surfeit 2. (257 aa)

Predicted Functional Partners:

surf4

0.587

W5M8Y9_LEPOC

0.574

W5M901_LEPOC

0.541

prepl

0.526

med22

0.512

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
W5M8Y9_LEPOC	W5M901_LEPOC	ENSLOCP00000004848	ENSLOCP00000004860	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.	Surfeit 6.	0.509
W5M8Y9_LEPOC	med22	ENSLOCP00000004848	ENSLOCP00000000641	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.	Mediator complex subunit 22.	0.506
W5M8Y9_LEPOC	surf2	ENSLOCP00000004848	ENSLOCP00000006438	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.	Surfeit 2.	0.574
W5M8Y9_LEPOC	surf4	ENSLOCP00000004848	ENSLOCP00000006454	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.	Surfeit 4.	0.667
W5M901_LEPOC	W5M8Y9_LEPOC	ENSLOCP00000004860	ENSLOCP00000004848	Surfeit 6.	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.	0.509
W5M901_LEPOC	med22	ENSLOCP00000004860	ENSLOCP00000000641	Surfeit 6.	Mediator complex subunit 22.	0.657
W5M901_LEPOC	surf2	ENSLOCP00000004860	ENSLOCP00000006438	Surfeit 6.	Surfeit 2.	0.541
W5M901_LEPOC	surf4	ENSLOCP00000004860	ENSLOCP00000006454	Surfeit 6.	Surfeit 4.	0.539
med22	W5M8Y9_LEPOC	ENSLOCP00000000641	ENSLOCP00000004848	Mediator complex subunit 22.	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.	0.506
med22	W5M901_LEPOC	ENSLOCP00000000641	ENSLOCP00000004860	Mediator complex subunit 22.	Surfeit 6.	0.657
med22	surf2	ENSLOCP00000000641	ENSLOCP00000006438	Mediator complex subunit 22.	Surfeit 2.	0.512
med22	surf4	ENSLOCP00000000641	ENSLOCP00000006454	Mediator complex subunit 22.	Surfeit 4.	0.497
prepl	surf2	ENSLOCP00000020228	ENSLOCP00000006438	Prolyl endopeptidase like.	Surfeit 2.	0.526
surf2	W5M8Y9_LEPOC	ENSLOCP00000006438	ENSLOCP00000004848	Surfeit 2.	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.	0.574
surf2	W5M901_LEPOC	ENSLOCP00000006438	ENSLOCP00000004860	Surfeit 2.	Surfeit 6.	0.541
surf2	med22	ENSLOCP00000006438	ENSLOCP00000000641	Surfeit 2.	Mediator complex subunit 22.	0.512
surf2	prepl	ENSLOCP00000006438	ENSLOCP00000020228	Surfeit 2.	Prolyl endopeptidase like.	0.526
surf2	surf4	ENSLOCP00000006438	ENSLOCP00000006454	Surfeit 2.	Surfeit 4.	0.587
surf4	W5M8Y9_LEPOC	ENSLOCP00000006454	ENSLOCP00000004848	Surfeit 4.	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.	0.667
surf4	W5M901_LEPOC	ENSLOCP00000006454	ENSLOCP00000004860	Surfeit 4.	Surfeit 6.	0.539

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.895

expected number of edges:

11

PPI enrichment p-value:

1.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 100

1.34

2.22

1.96e-10

GO:0009059

Macromolecule biosynthetic process

11 of 164

1.17

1.72

1.96e-10

GO:0010467

Gene expression

11 of 187

1.11

1.57

1.96e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 244

1.0

1.26

1.51e-09

GO:0044238

Primary metabolic process

11 of 736

0.52

0.45

0.00011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.6

3.41

7.00e-13

GO:0019843

rRNA binding

8 of 41

1.64

3.03

5.68e-10

GO:0003723

RNA binding

9 of 99

1.3

1.97

4.42e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.34

1.08

0.0103

GO:0000049

tRNA binding

3 of 24

1.44

0.83

0.0156

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.59

3.45

1.16e-13

GO:0044391

Ribosomal subunit

4 of 14

1.8

2.22

9.87e-06

GO:0015934

Large ribosomal subunit

3 of 8

1.92

1.89

0.00012

GO:0032991

Protein-containing complex

5 of 143

0.89

0.69

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27330141

(2016) Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity.

7 of 26

1.78

2.96

3.35e-08

PMID:28977619

(2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression.

8 of 51

1.54

2.45

3.35e-08

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

4 of 8

2.04

1.98

0.00011

PMID:20019804

(2009) Transcriptome and proteome exploration to model translation efficiency and protein stability in Lactococcus lactis.

6 of 65

1.31

1.32

0.00015

PMID:30779773

(2019) Multiplexing polysome profiling experiments to study translation in Escherichia coli.

3 of 7

1.98

1.24

0.0040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95

rRNA-binding

8 of 31

1.76

3.73

1.37e-11

CL:86

Ribosome, and Translational elongation

11 of 69

1.55

3.38

1.30e-14

CL:89

Ribosome

10 of 59

1.57

3.36

2.01e-13

CL:91

Ribosome

9 of 50

1.6

3.28

4.05e-12

CL:147

Large ribosomal subunit rRNA binding, and Translation regulation

4 of 5

2.25

3.03

9.25e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

llm03010

Ribosome

10 of 55

1.6

3.53

9.24e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015934

Large ribosomal subunit

5 of 10

2.04

3.23

1.01e-07

GOCC:0005840

Ribosome

8 of 45

1.59

2.87

9.60e-10

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 6

2.04

1.94

0.00013

GOCC:0043229

Intracellular organelle

10 of 224

0.99

1.19

5.88e-08

GOCC:0032991

Protein-containing complex

6 of 331

0.6

0.38

0.0297

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.6

3.45

2.01e-13

KW-0699

rRNA-binding

8 of 39

1.66

3.24

9.68e-11

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