node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
W5MBI2_LEPOC | W5NEJ3_LEPOC | ENSLOCP00000005741 | ENSLOCP00000019052 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex, subunit 5. | 0.999 |
W5MBI2_LEPOC | W5NJX2_LEPOC | ENSLOCP00000005741 | ENSLOCP00000020931 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex, subunit 3. | 0.999 |
W5MBI2_LEPOC | cdc6 | ENSLOCP00000005741 | ENSLOCP00000016700 | Chromatin licensing and DNA replication factor 1. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.999 |
W5MBI2_LEPOC | mcm2 | ENSLOCP00000005741 | ENSLOCP00000016756 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
W5MBI2_LEPOC | mcm4 | ENSLOCP00000005741 | ENSLOCP00000007283 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
W5MBI2_LEPOC | mcm7 | ENSLOCP00000005741 | ENSLOCP00000016112 | Chromatin licensing and DNA replication factor 1. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
W5MBI2_LEPOC | orc1 | ENSLOCP00000005741 | ENSLOCP00000007589 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
W5MBI2_LEPOC | orc2 | ENSLOCP00000005741 | ENSLOCP00000012023 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex, subunit 2. | 0.998 |
W5MBI2_LEPOC | orc4 | ENSLOCP00000005741 | ENSLOCP00000001571 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. | 0.999 |
W5MBI2_LEPOC | orc6 | ENSLOCP00000005741 | ENSLOCP00000006621 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex, subunit 6. | 0.964 |
W5NEJ3_LEPOC | W5MBI2_LEPOC | ENSLOCP00000019052 | ENSLOCP00000005741 | Origin recognition complex, subunit 5. | Chromatin licensing and DNA replication factor 1. | 0.999 |
W5NEJ3_LEPOC | W5NJX2_LEPOC | ENSLOCP00000019052 | ENSLOCP00000020931 | Origin recognition complex, subunit 5. | Origin recognition complex, subunit 3. | 0.999 |
W5NEJ3_LEPOC | cdc6 | ENSLOCP00000019052 | ENSLOCP00000016700 | Origin recognition complex, subunit 5. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.999 |
W5NEJ3_LEPOC | mcm2 | ENSLOCP00000019052 | ENSLOCP00000016756 | Origin recognition complex, subunit 5. | DNA helicase; Belongs to the MCM family. | 0.998 |
W5NEJ3_LEPOC | mcm4 | ENSLOCP00000019052 | ENSLOCP00000007283 | Origin recognition complex, subunit 5. | DNA helicase; Belongs to the MCM family. | 0.996 |
W5NEJ3_LEPOC | mcm7 | ENSLOCP00000019052 | ENSLOCP00000016112 | Origin recognition complex, subunit 5. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.996 |
W5NEJ3_LEPOC | orc1 | ENSLOCP00000019052 | ENSLOCP00000007589 | Origin recognition complex, subunit 5. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
W5NEJ3_LEPOC | orc2 | ENSLOCP00000019052 | ENSLOCP00000012023 | Origin recognition complex, subunit 5. | Origin recognition complex, subunit 2. | 0.999 |
W5NEJ3_LEPOC | orc4 | ENSLOCP00000019052 | ENSLOCP00000001571 | Origin recognition complex, subunit 5. | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. | 0.999 |
W5NEJ3_LEPOC | orc6 | ENSLOCP00000019052 | ENSLOCP00000006621 | Origin recognition complex, subunit 5. | Origin recognition complex, subunit 6. | 0.999 |