STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dlx2Distal-less homeobox 2a. (274 aa)    
Predicted Functional Partners:
dlx1
Distal-less homeobox 1a.
   
 
0.844
irx1
Iroquois homeobox 1a.
    
 
 0.551
irx2
Iroquois homeobox 2a.
   
 
 0.531
ascl2
Achaete-scute family bHLH transcription factor 1b.
      
 0.518
lef1
Lymphoid enhancer-binding factor 1.
    
 0.510
irx5
Iroquois homeobox 5b.
   
 
 0.509
bmp4
Bone morphogenetic protein 4.
     
 0.504
rag2
Recombination activating gene 2.
      
 0.478
rag1
V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...]
      
 0.436
zic2
Zic family member 2 (odd-paired homolog, Drosophila), a.
   
 
 0.432
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.