STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ube3aUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (899 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.994
ube2l3
Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.946
tsc2
TSC complex subunit 2.
    
 0.914
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 0.908
psmd14
Proteasome 26S subunit, non-ATPase 14.
    
 
 0.884
LOC102697582
TSC complex subunit 1a.
    
 0.874
W5MVL4_LEPOC
Scribble planar cell polarity protein.
 
  
 0.846
W5NJS8_LEPOC
Leucine rich repeat containing 1.
 
  
 0.846
NFX1
Nuclear transcription factor, X-box binding 1.
     
 0.810
nfxl1
Nuclear transcription factor, X-box binding-like 1.
     
 0.810
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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