fam20c protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

fam20c

FAM20C golgi associated secretory pathway kinase b. (570 aa)

Predicted Functional Partners:

fam20a

0.984

fam20b

0.870

W5MP76_LEPOC

0.736

pcsk9

0.716

penk

0.714

fgf23

0.707

serpinc1

0.701

AHSG

0.701

W5MWB6_LEPOC

0.701

W5MXT3_LEPOC

0.701

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHSG	W5MP76_LEPOC	ENSLOCP00000001842	ENSLOCP00000010185	Alpha 2-HS glycoprotein.	Fibrinogen alpha chain.	0.959
AHSG	W5MWB6_LEPOC	ENSLOCP00000001842	ENSLOCP00000012675	Alpha 2-HS glycoprotein.	Uncharacterized protein.	0.748
AHSG	fam20a	ENSLOCP00000001842	ENSLOCP00000015270	Alpha 2-HS glycoprotein.	FAM20A golgi associated secretory pathway pseudokinase.	0.619
AHSG	fam20b	ENSLOCP00000001842	ENSLOCP00000012876	Alpha 2-HS glycoprotein.	FAM20B glycosaminoglycan xylosylkinase.	0.504
AHSG	fam20c	ENSLOCP00000001842	ENSLOCP00000010623	Alpha 2-HS glycoprotein.	FAM20C golgi associated secretory pathway kinase b.	0.701
AHSG	serpinc1	ENSLOCP00000001842	ENSLOCP00000000289	Alpha 2-HS glycoprotein.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.809
W5MP76_LEPOC	AHSG	ENSLOCP00000010185	ENSLOCP00000001842	Fibrinogen alpha chain.	Alpha 2-HS glycoprotein.	0.959
W5MP76_LEPOC	W5MWB6_LEPOC	ENSLOCP00000010185	ENSLOCP00000012675	Fibrinogen alpha chain.	Uncharacterized protein.	0.667
W5MP76_LEPOC	fam20c	ENSLOCP00000010185	ENSLOCP00000010623	Fibrinogen alpha chain.	FAM20C golgi associated secretory pathway kinase b.	0.736
W5MP76_LEPOC	serpinc1	ENSLOCP00000010185	ENSLOCP00000000289	Fibrinogen alpha chain.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.962
W5MWB6_LEPOC	AHSG	ENSLOCP00000012675	ENSLOCP00000001842	Uncharacterized protein.	Alpha 2-HS glycoprotein.	0.748
W5MWB6_LEPOC	W5MP76_LEPOC	ENSLOCP00000012675	ENSLOCP00000010185	Uncharacterized protein.	Fibrinogen alpha chain.	0.667
W5MWB6_LEPOC	fam20a	ENSLOCP00000012675	ENSLOCP00000015270	Uncharacterized protein.	FAM20A golgi associated secretory pathway pseudokinase.	0.581
W5MWB6_LEPOC	fam20b	ENSLOCP00000012675	ENSLOCP00000012876	Uncharacterized protein.	FAM20B glycosaminoglycan xylosylkinase.	0.494
W5MWB6_LEPOC	fam20c	ENSLOCP00000012675	ENSLOCP00000010623	Uncharacterized protein.	FAM20C golgi associated secretory pathway kinase b.	0.701
W5MWB6_LEPOC	serpinc1	ENSLOCP00000012675	ENSLOCP00000000289	Uncharacterized protein.	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	0.585
W5MXT3_LEPOC	fam20c	ENSLOCP00000013192	ENSLOCP00000010623	Amyloid beta (A4) precursor protein b.	FAM20C golgi associated secretory pathway kinase b.	0.701
fam20a	AHSG	ENSLOCP00000015270	ENSLOCP00000001842	FAM20A golgi associated secretory pathway pseudokinase.	Alpha 2-HS glycoprotein.	0.619
fam20a	W5MWB6_LEPOC	ENSLOCP00000015270	ENSLOCP00000012675	FAM20A golgi associated secretory pathway pseudokinase.	Uncharacterized protein.	0.581
fam20a	fam20c	ENSLOCP00000015270	ENSLOCP00000010623	FAM20A golgi associated secretory pathway pseudokinase.	FAM20C golgi associated secretory pathway kinase b.	0.984

page 1 of 3

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098719

Sodium ion import across plasma membrane

5 of 10

3.04

5.3

1.66e-10

GO:0051453

Regulation of intracellular pH

5 of 65

2.23

3.21

3.32e-07

GO:0014067

Negative regulation of phosphatidylinositol 3-kinase signaling

3 of 6

3.04

2.96

4.14e-06

GO:0072657

Protein localization to membrane

4 of 333

1.42

1.07

0.0030

GO:0072659

Protein localization to plasma membrane

3 of 145

1.66

1.01

0.0082

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015385

Sodium:proton antiporter activity

5 of 11

3.0

5.46

7.96e-11

GO:0015386

Potassium:proton antiporter activity

5 of 14

2.89

5.34

1.06e-10

GO:0043495

Protein-membrane adaptor activity

3 of 26

2.4

2.32

4.04e-05

GO:0008013

Beta-catenin binding

3 of 58

2.05

1.77

0.00032

GO:0030674

Protein-macromolecule adaptor activity

4 of 304

1.46

1.25

0.00098

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098858

Actin-based cell projection

3 of 138

1.68

0.93

0.0129

GO:0016324

Apical plasma membrane

3 of 210

1.5

0.72

0.0330

GO:0005886

Plasma membrane

10 of 5545

0.6

0.44

0.0046

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:32013

Mixed, incl. Sodium ion import across plasma membrane, and Positive regulation of early endosome to late endosome transport

9 of 18

3.04

11.41

1.68e-22

CL:32014

Mixed, incl. Positive regulation of early endosome to late endosome transport, and Negative regulation of phosphatidylinositol 3-kinase signaling

6 of 12

3.04

7.2

3.87e-14

CL:32016

EBP50, C-terminal, and Positive regulation of early endosome to late endosome transport

3 of 5

3.12

2.98

3.89e-06

CL:32037

Mixed, incl. Regulatory region of Na+/H+ exchanger NHE binds to calmodulin, and Cellular response to acidic pH

3 of 6

3.04

2.92

4.86e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04810

Regulation of actin cytoskeleton

5 of 343

1.5

1.66

5.13e-05

map04260

Cardiac muscle contraction

3 of 176

1.57

1.03

0.0062

map04371

Apelin signaling pathway

3 of 230

1.46

0.92

0.0091

map04530

Tight junction

3 of 275

1.38

0.86

0.0114

map04261

Adrenergic signaling in cardiomyocytes

3 of 283

1.37

0.85

0.0114

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-425986

Sodium/Proton exchangers

5 of 11

3.0

5.56

4.97e-11

MAP-425393

Transport of inorganic cations/anions and amino acids/oligopeptides

5 of 191

1.76

2.14

1.25e-05

MAP-425407

SLC-mediated transmembrane transport

5 of 431

1.4

1.3

0.00045

MAP-2160916

Hyaluronan uptake and degradation

2 of 14

2.5

1.11

0.0094

MAP-2142845

Hyaluronan metabolism

2 of 29

2.18

0.83

0.0292

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005902

Microvillus

3 of 33

2.3

1.65

0.00077

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0050

Antiport

5 of 13

2.93

5.71

2.17e-11

KW-0739

Sodium transport

5 of 23

2.68

5.18

1.24e-10

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00999

Sodium/hydrogen exchanger family

5 of 14

2.89

5.22

1.86e-10

PF16644

Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

4 of 4

3.34

4.8

1.93e-09

PF09007

EBP50, C-terminal

2 of 2

3.34

1.69

0.00089

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