W5MRX6_LEPOC protein (Lepisosteus oculatus) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

W5MRX6_LEPOC

Uncharacterized protein. (1251 aa)

Predicted Functional Partners:

magi3

0.726

W5NC44_LEPOC

0.726

ift57

0.708

traf3ip1

0.692

W5NFZ6_LEPOC

0.644

cask

0.617

cluap1

0.588

ift81

0.576

ift52

0.569

LOC102687908

0.569

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102687908	W5MRX6_LEPOC	ENSLOCP00000008219	ENSLOCP00000011135	Fleer.	Uncharacterized protein.	0.569
LOC102687908	W5NFZ6_LEPOC	ENSLOCP00000008219	ENSLOCP00000019555	Fleer.	Intraflagellar transport 172.	0.995
LOC102687908	cluap1	ENSLOCP00000008219	ENSLOCP00000003972	Fleer.	Clusterin associated protein 1.	0.994
LOC102687908	ift52	ENSLOCP00000008219	ENSLOCP00000001567	Fleer.	Intraflagellar transport 52 homolog (Chlamydomonas).	0.995
LOC102687908	ift57	ENSLOCP00000008219	ENSLOCP00000015660	Fleer.	Intraflagellar transport 57 homolog (Chlamydomonas).	0.995
LOC102687908	ift81	ENSLOCP00000008219	ENSLOCP00000008655	Fleer.	Intraflagellar transport 81 homolog.	0.995
LOC102687908	traf3ip1	ENSLOCP00000008219	ENSLOCP00000011056	Fleer.	TNF receptor-associated factor 3 interacting protein 1.	0.994
W5MRX6_LEPOC	LOC102687908	ENSLOCP00000011135	ENSLOCP00000008219	Uncharacterized protein.	Fleer.	0.569
W5MRX6_LEPOC	W5NC44_LEPOC	ENSLOCP00000011135	ENSLOCP00000018203	Uncharacterized protein.	MAGI family member, X-linked b.	0.726
W5MRX6_LEPOC	W5NFZ6_LEPOC	ENSLOCP00000011135	ENSLOCP00000019555	Uncharacterized protein.	Intraflagellar transport 172.	0.644
W5MRX6_LEPOC	cask	ENSLOCP00000011135	ENSLOCP00000002407	Uncharacterized protein.	Calcium/calmodulin-dependent serine protein kinase a; Belongs to the MAGUK family.	0.617
W5MRX6_LEPOC	cluap1	ENSLOCP00000011135	ENSLOCP00000003972	Uncharacterized protein.	Clusterin associated protein 1.	0.588
W5MRX6_LEPOC	ift52	ENSLOCP00000011135	ENSLOCP00000001567	Uncharacterized protein.	Intraflagellar transport 52 homolog (Chlamydomonas).	0.569
W5MRX6_LEPOC	ift57	ENSLOCP00000011135	ENSLOCP00000015660	Uncharacterized protein.	Intraflagellar transport 57 homolog (Chlamydomonas).	0.708
W5MRX6_LEPOC	ift81	ENSLOCP00000011135	ENSLOCP00000008655	Uncharacterized protein.	Intraflagellar transport 81 homolog.	0.576
W5MRX6_LEPOC	magi3	ENSLOCP00000011135	ENSLOCP00000013506	Uncharacterized protein.	Membrane associated guanylate kinase, WW and PDZ domain containing 3b.	0.726
W5MRX6_LEPOC	traf3ip1	ENSLOCP00000011135	ENSLOCP00000011056	Uncharacterized protein.	TNF receptor-associated factor 3 interacting protein 1.	0.692
W5NC44_LEPOC	W5MRX6_LEPOC	ENSLOCP00000018203	ENSLOCP00000011135	MAGI family member, X-linked b.	Uncharacterized protein.	0.726
W5NC44_LEPOC	cask	ENSLOCP00000018203	ENSLOCP00000002407	MAGI family member, X-linked b.	Calcium/calmodulin-dependent serine protein kinase a; Belongs to the MAGUK family.	0.757
W5NC44_LEPOC	magi3	ENSLOCP00000018203	ENSLOCP00000013506	MAGI family member, X-linked b.	Membrane associated guanylate kinase, WW and PDZ domain containing 3b.	0.911

page 1 of 4

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008654

Phospholipid biosynthetic process

10 of 209

1.99

5.62

5.76e-16

GO:0006650

Glycerophospholipid metabolic process

10 of 262

1.89

5.04

2.62e-15

GO:0006658

Phosphatidylserine metabolic process

5 of 21

2.69

4.91

4.35e-10

GO:0046474

Glycerophospholipid biosynthetic process

8 of 178

1.96

4.53

3.64e-12

GO:0046470

Phosphatidylcholine metabolic process

5 of 32

2.5

4.4

2.65e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016780

Phosphotransferase activity, for other substituted phosphate groups

6 of 23

2.72

5.98

3.29e-12

GO:0106245

L-serine-phosphatidylethanolamine phosphatidyltransferase activity

3 of 3

3.31

3.12

2.32e-06

GO:0017169

CDP-alcohol phosphatidyltransferase activity

3 of 5

3.09

2.95

4.32e-06

GO:0106258

L-serine-phosphatidylcholine phosphatidyltransferase activity

2 of 2

3.31

1.8

0.00058

GO:0004307

Ethanolaminephosphotransferase activity

2 of 2

3.31

1.8

0.00058

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005789

Endoplasmic reticulum membrane

9 of 878

1.32

1.96

1.49e-08

GO:0031090

Organelle membrane

11 of 2810

0.9

1.02

3.15e-08

GO:0012505

Endomembrane system

10 of 3368

0.78

0.75

1.03e-05

GO:0016021

Integral component of membrane

10 of 5655

0.56

0.44

0.0014

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17732

Mixed, incl. Synthesis of PA, and Phosphotransferase activity, for other substituted phosphate groups

11 of 63

2.55

10.95

1.09e-24

CL:17838

Mixed, incl. Synthesis of PS, and Ethanolaminephosphotransferase activity

7 of 10

3.15

9.12

1.06e-17

CL:17841

Synthesis of PS, and Glycine betaine metabolic process

4 of 5

3.21

4.67

3.05e-09

CL:17734

Synthesis of PA, and Lysophospholipase activity

4 of 51

2.2

2.6

7.00e-06

CL:17736

Mixed, incl. CDP-diacylglycerol metabolic process, and glycerol-3-phosphate metabolic process

3 of 32

2.28

1.83

0.00033

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00564

Glycerophospholipid metabolism

11 of 197

2.06

7.11

6.78e-21

map00440

Phosphonate and phosphinate metabolism

3 of 9

2.83

3.1

1.92e-06

map00565

Ether lipid metabolism

3 of 80

1.88

1.66

0.00039

map01100

Metabolic pathways

10 of 3053

0.82

0.84

1.92e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483206

Glycerophospholipid biosynthesis

11 of 190

2.07

7.03

3.87e-20

MAP-1483257

Phospholipid metabolism

11 of 318

1.85

5.35

4.88e-18

MAP-1483101

Synthesis of PS

3 of 3

3.31

3.44

5.87e-07

MAP-556833

Metabolism of lipids

11 of 986

1.36

2.46

7.22e-13

MAP-1483213

Synthesis of PE

3 of 18

2.53

2.4

3.24e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0594

Phospholipid biosynthesis

2 of 9

2.66

1.3

0.0042

KW-1133

Transmembrane helix

10 of 6095

0.52

0.4

0.0042

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03034

Phosphatidyl serine synthase

3 of 3

3.31

2.99

4.00e-06

PF01066

CDP-alcohol phosphatidyltransferase

3 of 6

3.01

2.79

8.39e-06

PF03062

MBOAT, membrane-bound O-acyltransferase family

2 of 14

2.46

0.93

0.0198

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