STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (179 aa)    
Predicted Functional Partners:
cdk4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.952
cdk6
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.952
ccnd1
Cyclin D1; Belongs to the cyclin family.
    
 0.919
ccnd2
Cyclin D2, b; Belongs to the cyclin family.
    
 0.919
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.901
LOC102690243
Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily.
    
  0.884
CDK2
Cyclin dependent kinase 2.
   
 0.877
cdk1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.877
W5N4M9_LEPOC
Cyclin D3; Belongs to the cyclin family.
    
 0.813
cdk18
Cyclin dependent kinase 18.
   
 0.712
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.