W5MV98_LEPOC protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

W5MV98_LEPOC

Si:ch211-247j9.1. (634 aa)

Predicted Functional Partners:

cdc42

0.720

LOC102698253

0.648

RAC3

0.587

rac1

0.586

LOC102690743

0.513

rhof

0.506

rnd1

0.503

rnd3

0.500

rhoc

0.499

LOC102682211

0.499

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102682211	LOC102690743	ENSLOCP00000017610	ENSLOCP00000021588	Ras homolog gene family, member Ab.	Ras homolog gene family, member Gc.	0.585
LOC102682211	LOC102698253	ENSLOCP00000017610	ENSLOCP00000008990	Ras homolog gene family, member Ab.	Cell division cycle 42, like.	0.715
LOC102682211	RAC3	ENSLOCP00000017610	ENSLOCP00000015230	Ras homolog gene family, member Ab.	Rac family small GTPase 3.	0.681
LOC102682211	W5MV98_LEPOC	ENSLOCP00000017610	ENSLOCP00000012307	Ras homolog gene family, member Ab.	Si:ch211-247j9.1.	0.499
LOC102682211	cdc42	ENSLOCP00000017610	ENSLOCP00000001212	Ras homolog gene family, member Ab.	Cell division cycle 42.	0.789
LOC102682211	rac1	ENSLOCP00000017610	ENSLOCP00000010207	Ras homolog gene family, member Ab.	Rac family small GTPase 1b.	0.681
LOC102682211	rhof	ENSLOCP00000017610	ENSLOCP00000006224	Ras homolog gene family, member Ab.	Ras homolog family member F.	0.547
LOC102682211	rnd1	ENSLOCP00000017610	ENSLOCP00000008942	Ras homolog gene family, member Ab.	Rho family GTPase 1a.	0.524
LOC102682211	rnd3	ENSLOCP00000017610	ENSLOCP00000001797	Ras homolog gene family, member Ab.	Rho family GTPase 3b.	0.521
LOC102690743	LOC102682211	ENSLOCP00000021588	ENSLOCP00000017610	Ras homolog gene family, member Gc.	Ras homolog gene family, member Ab.	0.585
LOC102690743	LOC102698253	ENSLOCP00000021588	ENSLOCP00000008990	Ras homolog gene family, member Gc.	Cell division cycle 42, like.	0.599
LOC102690743	RAC3	ENSLOCP00000021588	ENSLOCP00000015230	Ras homolog gene family, member Gc.	Rac family small GTPase 3.	0.660
LOC102690743	W5MV98_LEPOC	ENSLOCP00000021588	ENSLOCP00000012307	Ras homolog gene family, member Gc.	Si:ch211-247j9.1.	0.513
LOC102690743	cdc42	ENSLOCP00000021588	ENSLOCP00000001212	Ras homolog gene family, member Gc.	Cell division cycle 42.	0.642
LOC102690743	rac1	ENSLOCP00000021588	ENSLOCP00000010207	Ras homolog gene family, member Gc.	Rac family small GTPase 1b.	0.660
LOC102690743	rhoc	ENSLOCP00000021588	ENSLOCP00000012596	Ras homolog gene family, member Gc.	Ras homolog family member Cb.	0.585
LOC102690743	rhof	ENSLOCP00000021588	ENSLOCP00000006224	Ras homolog gene family, member Gc.	Ras homolog family member F.	0.566
LOC102690743	rnd1	ENSLOCP00000021588	ENSLOCP00000008942	Ras homolog gene family, member Gc.	Rho family GTPase 1a.	0.588
LOC102690743	rnd3	ENSLOCP00000021588	ENSLOCP00000001797	Ras homolog gene family, member Gc.	Rho family GTPase 3b.	0.583
LOC102698253	LOC102682211	ENSLOCP00000008990	ENSLOCP00000017610	Cell division cycle 42, like.	Ras homolog gene family, member Ab.	0.715

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.623

expected number of edges:

10

PPI enrichment p-value:

2.77e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

11 of 340

1.06

1.39

2.78e-09

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022857

Transmembrane transporter activity

11 of 341

1.06

1.4

1.61e-09

GO:0015562

Efflux transmembrane transporter activity

3 of 15

1.85

1.28

0.0028

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016020

Membrane

11 of 1202

0.52

0.44

0.00026

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6452

Acriflavin resistance protein, and RND efflux pump, membrane fusion protein

11 of 29

2.13

7.43

2.33e-20

CL:6454

Acriflavin resistance protein, and RND efflux pump, membrane fusion protein

10 of 23

2.19

7.21

1.83e-18

CL:6483

Palmitate, and Hydrophobe/amphiphile efflux-1 HAE1

5 of 6

2.47

4.41

2.18e-09

CL:6455

Acriflavin resistance protein, and RND efflux pump, membrane fusion protein, barrel-sandwich domain

3 of 14

1.88

1.52

0.00081

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01501

beta-Lactam resistance

10 of 86

1.62

3.61

6.23e-14

map01503

Cationic antimicrobial peptide (CAMP) resistance

7 of 74

1.53

2.45

2.33e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990281

Efflux pump complex

5 of 14

2.11

3.5

3.35e-08

GOCC:1902495

Transmembrane transporter complex

7 of 42

1.78

3.4

7.02e-10

GOCC:0016021

Integral component of membrane

11 of 128

1.49

3.1

2.12e-14

GOCC:0098796

Membrane protein complex

10 of 124

1.46

2.81

1.57e-12

GOCC:0046930

Pore complex

3 of 29

1.57

1.17

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0564

Palmitate

3 of 3

2.55

2.41

3.18e-05

KW-0175

Coiled coil

10 of 373

0.98

1.15

1.32e-07

KW-1134

Transmembrane beta strand

3 of 29

1.57

1.07

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13533

Biotin-lipoyl like

5 of 10

2.25

3.46

1.04e-07

PF13437

HlyD family secretion protein

4 of 13

2.04

2.27

2.32e-05

PF02321

Outer membrane efflux protein

4 of 13

2.04

2.27

2.32e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006143

RND efflux pump, membrane fusion protein

6 of 12

2.25

4.15

2.41e-09

IPR032317

RND efflux pump, membrane fusion protein, barrel-sandwich domain

5 of 11

2.21

3.31

1.86e-07

IPR003423

Outer membrane efflux protein

4 of 13

2.04

2.18

3.78e-05

IPR010131

RND efflux system, outer membrane lipoprotein, NodT

3 of 3

2.55

2.11

0.00012

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