STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5MWY2_LEPOCHomeodomain interacting protein kinase 1a. (1183 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.938
RASSF5
Ras association domain family member 5.
    
  0.876
hipk3
Homeodomain interacting protein kinase 3b.
  
  
 
0.830
dcaf7
Ddb1 and cul4 associated factor 7.
   
 
 0.770
HIPK4
Homeodomain interacting protein kinase 4; Belongs to the protein kinase superfamily.
  
  
 
0.699
hipk2
Homeodomain interacting protein kinase 2.
  
  
 
0.697
pin1
Peptidyl-prolyl cis-trans isomerase.
    
 0.688
W5NBX2_LEPOC
Methyl CpG binding protein 2.
    
 0.642
sumo1
Small ubiquitin-related modifier.
    
 0.633
cbfb
Core-binding factor subunit beta.
     
 0.626
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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