ankrd55 protein (Lepisosteus oculatus) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

ankrd55

Ankyrin repeat domain 55. (668 aa)

Predicted Functional Partners:

ift52

0.780

ift46

0.770

LOC102687908

0.720

ift74

0.689

W5M6P3_LEPOC

0.689

W5MW92_LEPOC

0.569

ift81

0.568

ift22

0.558

lratd1

0.550

W5LW97_LEPOC

0.547

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102687908	ankrd55	ENSLOCP00000008219	ENSLOCP00000013410	Fleer.	Ankyrin repeat domain 55.	0.720
LOC102687908	ift22	ENSLOCP00000008219	ENSLOCP00000002835	Fleer.	Intraflagellar transport 22 homolog (Chlamydomonas).	0.953
LOC102687908	ift46	ENSLOCP00000008219	ENSLOCP00000006917	Fleer.	Intraflagellar transport 46 homolog (Chlamydomonas).	0.993
LOC102687908	ift52	ENSLOCP00000008219	ENSLOCP00000001567	Fleer.	Intraflagellar transport 52 homolog (Chlamydomonas).	0.995
LOC102687908	ift74	ENSLOCP00000008219	ENSLOCP00000003715	Fleer.	Intraflagellar transport 74.	0.989
LOC102687908	ift81	ENSLOCP00000008219	ENSLOCP00000008655	Fleer.	Intraflagellar transport 81 homolog.	0.995
W5LW97_LEPOC	ankrd55	ENSLOCP00000000404	ENSLOCP00000013410	tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Ankyrin repeat domain 55.	0.547
W5LW97_LEPOC	ift74	ENSLOCP00000000404	ENSLOCP00000003715	tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Intraflagellar transport 74.	0.547
W5M6P3_LEPOC	W5MW92_LEPOC	ENSLOCP00000004051	ENSLOCP00000012651	WD repeat domain 90.	Uncharacterized protein.	0.546
W5M6P3_LEPOC	ankrd55	ENSLOCP00000004051	ENSLOCP00000013410	WD repeat domain 90.	Ankyrin repeat domain 55.	0.689
W5MW92_LEPOC	W5M6P3_LEPOC	ENSLOCP00000012651	ENSLOCP00000004051	Uncharacterized protein.	WD repeat domain 90.	0.546
W5MW92_LEPOC	ankrd55	ENSLOCP00000012651	ENSLOCP00000013410	Uncharacterized protein.	Ankyrin repeat domain 55.	0.569
ankrd55	LOC102687908	ENSLOCP00000013410	ENSLOCP00000008219	Ankyrin repeat domain 55.	Fleer.	0.720
ankrd55	W5LW97_LEPOC	ENSLOCP00000013410	ENSLOCP00000000404	Ankyrin repeat domain 55.	tRNA-synt_1g domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.547
ankrd55	W5M6P3_LEPOC	ENSLOCP00000013410	ENSLOCP00000004051	Ankyrin repeat domain 55.	WD repeat domain 90.	0.689
ankrd55	W5MW92_LEPOC	ENSLOCP00000013410	ENSLOCP00000012651	Ankyrin repeat domain 55.	Uncharacterized protein.	0.569
ankrd55	ift22	ENSLOCP00000013410	ENSLOCP00000002835	Ankyrin repeat domain 55.	Intraflagellar transport 22 homolog (Chlamydomonas).	0.558
ankrd55	ift46	ENSLOCP00000013410	ENSLOCP00000006917	Ankyrin repeat domain 55.	Intraflagellar transport 46 homolog (Chlamydomonas).	0.770
ankrd55	ift52	ENSLOCP00000013410	ENSLOCP00000001567	Ankyrin repeat domain 55.	Intraflagellar transport 52 homolog (Chlamydomonas).	0.780
ankrd55	ift74	ENSLOCP00000013410	ENSLOCP00000003715	Ankyrin repeat domain 55.	Intraflagellar transport 74.	0.689

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.785

expected number of edges:

13

PPI enrichment p-value:

0.000944

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1903475

Mitotic actomyosin contractile ring assembly

3 of 10

2.51

1.76

0.00056

GO:0007010

Cytoskeleton organization

4 of 178

1.38

1.01

0.0039

GO:0007049

Cell cycle

5 of 393

1.13

0.85

0.0039

GO:0022402

Cell cycle process

4 of 310

1.14

0.65

0.0241

GO:0006996

Organelle organization

6 of 890

0.86

0.57

0.0128

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003779

Actin binding

4 of 74

1.76

1.47

0.00079

GO:0051015

Actin filament binding

3 of 36

1.95

1.26

0.0035

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015629

Actin cytoskeleton

5 of 75

1.85

2.4

4.44e-06

GO:0016459

Myosin complex

3 of 10

2.51

2.32

4.49e-05

GO:0005826

Actomyosin contractile ring

3 of 10

2.51

2.32

4.49e-05

GO:0016460

Myosin II complex

2 of 3

2.85

1.65

0.0010

GO:0005856

Cytoskeleton

6 of 261

1.39

1.61

2.10e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3809

Contractile ring, and Muscle contraction

7 of 14

2.73

7.2

9.69e-15

CL:3827

Mixed, incl. Tropomyosin, and Glyoxalase III activity

4 of 5

2.93

4.38

8.20e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9716542

Signaling by Rho GTPases, Miro GTPases and RHOBTB3

5 of 271

1.3

1.01

0.0026

MAP-5627123

RHO GTPases activate PAKs

2 of 9

2.38

0.93

0.0201

MAP-9013424

RHOV GTPase cycle

2 of 15

2.15

0.87

0.0247

MAP-397014

Muscle contraction

2 of 19

2.05

0.85

0.0254

MAP-195258

RHO GTPase Effectors

3 of 106

1.48

0.76

0.0247

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015629

Actin cytoskeleton

6 of 60

2.03

3.58

1.03e-08

GOCC:0005856

Cytoskeleton

7 of 215

1.54

2.35

1.11e-07

GOCC:0016459

Myosin complex

3 of 11

2.47

2.22

6.84e-05

GOCC:0099512

Supramolecular fiber

3 of 26

2.09

1.69

0.00051

GOCC:0110085

Mitotic actomyosin contractile ring

2 of 11

2.29

1.15

0.0072

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0518

Myosin

2 of 9

2.38

1.08

0.0102

KW-0009

Actin-binding

2 of 21

2.01

0.91

0.0193

KW-0175

Coiled coil

6 of 1289

0.7

0.43

0.0289

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000048

IQ motif, EF-hand binding site

3 of 6

2.73

2.12

0.00013

IPR004009

Myosin, N-terminal, SH3-like

2 of 2

3.03

1.23

0.0061

IPR001609

Myosin head, motor domain

2 of 9

2.38

0.78

0.0374

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00015

Short calmodulin-binding motif containing conserved Ile and Gln residues.

2 of 4

2.73

1.34

0.0036

SM00242

Myosin. Large ATPases.

2 of 7

2.49

1.29

0.0043

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