phb protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

phb

Prohibitin. (273 aa)

Predicted Functional Partners:

phb2

0.999

spg7

0.944

W5LYT8_LEPOC

0.935

afg3l2

0.935

stoml2

0.874

pmpca

0.865

c1qbp

0.861

LOC102696097

0.838

YME1L1

0.838

vdac1

0.775

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102696097	W5LYT8_LEPOC	ENSLOCP00000000418	ENSLOCP00000001295	Uncharacterized protein.	Si:ch1073-174d20.2.	0.415
LOC102696097	afg3l2	ENSLOCP00000000418	ENSLOCP00000014894	Uncharacterized protein.	AFG3-like AAA ATPase 2.	0.411
LOC102696097	phb	ENSLOCP00000000418	ENSLOCP00000014061	Uncharacterized protein.	Prohibitin.	0.838
LOC102696097	phb2	ENSLOCP00000000418	ENSLOCP00000001593	Uncharacterized protein.	Prohibitin.	0.840
LOC102696097	pmpca	ENSLOCP00000000418	ENSLOCP00000004160	Uncharacterized protein.	Peptidase (mitochondrial processing) alpha; Belongs to the peptidase M16 family.	0.600
LOC102696097	spg7	ENSLOCP00000000418	ENSLOCP00000005434	Uncharacterized protein.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.433
LOC102696097	stoml2	ENSLOCP00000000418	ENSLOCP00000005299	Uncharacterized protein.	Stomatin (EPB72)-like 2.	0.863
W5LYT8_LEPOC	LOC102696097	ENSLOCP00000001295	ENSLOCP00000000418	Si:ch1073-174d20.2.	Uncharacterized protein.	0.415
W5LYT8_LEPOC	YME1L1	ENSLOCP00000001295	ENSLOCP00000009146	Si:ch1073-174d20.2.	YME1 like 1 ATPase.	0.428
W5LYT8_LEPOC	afg3l2	ENSLOCP00000001295	ENSLOCP00000014894	Si:ch1073-174d20.2.	AFG3-like AAA ATPase 2.	0.545
W5LYT8_LEPOC	phb	ENSLOCP00000001295	ENSLOCP00000014061	Si:ch1073-174d20.2.	Prohibitin.	0.935
W5LYT8_LEPOC	phb2	ENSLOCP00000001295	ENSLOCP00000001593	Si:ch1073-174d20.2.	Prohibitin.	0.906
W5LYT8_LEPOC	pmpca	ENSLOCP00000001295	ENSLOCP00000004160	Si:ch1073-174d20.2.	Peptidase (mitochondrial processing) alpha; Belongs to the peptidase M16 family.	0.804
W5LYT8_LEPOC	spg7	ENSLOCP00000001295	ENSLOCP00000005434	Si:ch1073-174d20.2.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.903
W5LYT8_LEPOC	stoml2	ENSLOCP00000001295	ENSLOCP00000005299	Si:ch1073-174d20.2.	Stomatin (EPB72)-like 2.	0.764
YME1L1	W5LYT8_LEPOC	ENSLOCP00000009146	ENSLOCP00000001295	YME1 like 1 ATPase.	Si:ch1073-174d20.2.	0.428
YME1L1	afg3l2	ENSLOCP00000009146	ENSLOCP00000014894	YME1 like 1 ATPase.	AFG3-like AAA ATPase 2.	0.426
YME1L1	phb	ENSLOCP00000009146	ENSLOCP00000014061	YME1 like 1 ATPase.	Prohibitin.	0.838
YME1L1	phb2	ENSLOCP00000009146	ENSLOCP00000001593	YME1 like 1 ATPase.	Prohibitin.	0.840
YME1L1	pmpca	ENSLOCP00000009146	ENSLOCP00000004160	YME1 like 1 ATPase.	Peptidase (mitochondrial processing) alpha; Belongs to the peptidase M16 family.	0.600

page 1 of 5

Network Stats

number of nodes:

6

number of edges:

9

average node degree:

3

avg. local clustering coefficient:

0.8

expected number of edges:

8

PPI enrichment p-value:

0.412

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000387

Spliceosomal snRNP assembly

4 of 30

2.45

2.86

3.49e-06

GO:0040031

snRNA modification

3 of 8

2.9

2.63

1.54e-05

GO:0008380

RNA splicing

6 of 351

1.55

1.92

9.26e-06

GO:0000398

mRNA splicing, via spliceosome

5 of 229

1.66

1.86

4.08e-05

GO:0016071

mRNA metabolic process

7 of 575

1.41

1.78

3.85e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017069

snRNA binding

7 of 39

2.58

6.59

6.85e-14

GO:0017070

U6 snRNA binding

4 of 8

3.02

4.21

1.86e-08

GO:0003723

RNA binding

9 of 1208

1.19

1.57

1.37e-07

GO:0097322

7SK snRNA binding

2 of 5

2.92

1.46

0.0023

GO:1901363

Heterocyclic compound binding

10 of 6430

0.51

0.37

0.0105

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030532

Small nuclear ribonucleoprotein complex

5 of 59

2.25

3.5

8.06e-08

GO:0046540

U4/U6 x U5 tri-snRNP complex

4 of 32

2.42

3.19

6.88e-07

GO:0015030

Cajal body

4 of 36

2.37

3.17

6.88e-07

GO:0071005

U2-type precatalytic spliceosome

4 of 48

2.24

2.95

1.35e-06

GO:1990904

Ribonucleoprotein complex

7 of 598

1.39

1.89

6.88e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19743

Regulation of protein localization to Cajal body, and U6 snRNA 3-end binding

4 of 6

3.15

4.14

2.82e-08

CL:18977

Small nuclear ribonucleoprotein complex, and snRNA binding

5 of 66

2.2

3.24

2.60e-07

CL:19047

Spliceosomal tri-snRNP complex assembly, and U4/U6 x U5 tri-snRNP complex

3 of 10

2.8

2.65

1.34e-05

CL:18979

Spliceosomal snRNP complex, and snRNA binding

4 of 60

2.15

2.46

1.20e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

4 of 266

1.5

1.26

0.0011

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

5 of 391

1.43

1.31

0.00051

MAP-8953854

Metabolism of RNA

7 of 946

1.19

1.21

9.46e-05

MAP-72163

mRNA Splicing - Major Pathway

4 of 272

1.49

1.09

0.0034

MAP-72172

mRNA Splicing

4 of 296

1.45

1.06

0.0036

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

7 of 447

1.52

2.16

5.13e-07

GOCC:0005634

Nucleus

8 of 3501

0.68

0.43

0.0232

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