STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
retProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1111 aa)    
Predicted Functional Partners:
gfra2
GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
    
 0.985
nrtn
Neurturin.
    
 0.984
W5NJU6_LEPOC
GDNF domain-containing protein.
    
 0.976
gdnf
Glial cell derived neurotrophic factor a.
    
 0.975
dok1
Docking protein 1b.
    
  0.971
ccdc6
Coiled-coil domain containing 6b.
     
 0.930
W5N5Q1_LEPOC
GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family.
    
 0.892
grb2
Growth factor receptor-bound protein 2b.
    
 0.863
fgf8
Fibroblast growth factor 8 b; Belongs to the heparin-binding growth factors family.
    
 0.838
LOC102697185
TGF_BETA_2 domain-containing protein.
    
 
 0.808
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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