hcn1 protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

hcn1

Hyperpolarization activated cyclic nucleotide-gated potassium channel 1. (890 aa)

Predicted Functional Partners:

W5MYI3_LEPOC

0.643

hcn4

0.634

HCN2

0.629

W5NJL5_LEPOC

0.604

W5MI08_LEPOC

0.593

LOC102695217

0.511

scn8a

0.483

LOC102683457

0.483

SCN4A

0.459

KCNE2

0.404

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCN2	KCNE2	ENSLOCP00000006250	ENSLOCP00000021892	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.404
HCN2	LOC102683457	ENSLOCP00000006250	ENSLOCP00000012124	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.483
HCN2	LOC102695217	ENSLOCP00000006250	ENSLOCP00000010150	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.485
HCN2	SCN4A	ENSLOCP00000006250	ENSLOCP00000016267	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.459
HCN2	W5MI08_LEPOC	ENSLOCP00000006250	ENSLOCP00000008017	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	Uncharacterized protein.	0.594
HCN2	W5MYI3_LEPOC	ENSLOCP00000006250	ENSLOCP00000013442	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	Hyperpolarization activated cyclic nucleotide-gated potassium channel 5.	0.645
HCN2	W5NJL5_LEPOC	ENSLOCP00000006250	ENSLOCP00000020824	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	Cyclic nucleotide-binding domain-containing protein.	0.606
HCN2	hcn1	ENSLOCP00000006250	ENSLOCP00000014714	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	Hyperpolarization activated cyclic nucleotide-gated potassium channel 1.	0.629
HCN2	hcn4	ENSLOCP00000006250	ENSLOCP00000017912	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	Hyperpolarization activated cyclic nucleotide-gated potassium channel 4l.	0.631
HCN2	scn8a	ENSLOCP00000006250	ENSLOCP00000008195	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.483
KCNE2	HCN2	ENSLOCP00000021892	ENSLOCP00000006250	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	0.404
KCNE2	W5MI08_LEPOC	ENSLOCP00000021892	ENSLOCP00000008017	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Uncharacterized protein.	0.404
KCNE2	W5NJL5_LEPOC	ENSLOCP00000021892	ENSLOCP00000020824	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Cyclic nucleotide-binding domain-containing protein.	0.404
KCNE2	hcn1	ENSLOCP00000021892	ENSLOCP00000014714	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Hyperpolarization activated cyclic nucleotide-gated potassium channel 1.	0.404
KCNE2	hcn4	ENSLOCP00000021892	ENSLOCP00000017912	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Hyperpolarization activated cyclic nucleotide-gated potassium channel 4l.	0.404
LOC102683457	HCN2	ENSLOCP00000012124	ENSLOCP00000006250	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b.	0.483
LOC102683457	LOC102695217	ENSLOCP00000012124	ENSLOCP00000010150	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.547
LOC102683457	SCN4A	ENSLOCP00000012124	ENSLOCP00000016267	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.707
LOC102683457	W5MI08_LEPOC	ENSLOCP00000012124	ENSLOCP00000008017	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.483
LOC102683457	W5NJL5_LEPOC	ENSLOCP00000012124	ENSLOCP00000020824	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Cyclic nucleotide-binding domain-containing protein.	0.483