meox1 protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

meox1

Mesenchyme homeobox 1. (254 aa)

Predicted Functional Partners:

meox2

0.690

LOC102696492

0.447

pbx3

0.447

LOC102685540

0.447

LOC107078362

0.447

W5MIR5_LEPOC

0.447

LOC102690970

0.446

LOC102690906

0.446

myog

0.427

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102685540	LOC107078362	ENSLOCP00000005278	ENSLOCP00000005315	Homeobox domain-containing protein.	PBC domain-containing protein.	0.760
LOC102685540	meox1	ENSLOCP00000005278	ENSLOCP00000014919	Homeobox domain-containing protein.	Mesenchyme homeobox 1.	0.447
LOC102685540	meox2	ENSLOCP00000005278	ENSLOCP00000013854	Homeobox domain-containing protein.	Mesenchyme homeobox 2a.	0.447
LOC102690906	meox1	ENSLOCP00000007916	ENSLOCP00000014919	T-box transcription factor 16.	Mesenchyme homeobox 1.	0.446
LOC102690970	meox1	ENSLOCP00000003883	ENSLOCP00000014919	Uncharacterized protein.	Mesenchyme homeobox 1.	0.446
LOC102696492	meox1	ENSLOCP00000000497	ENSLOCP00000014919	Pre-B-cell leukemia homeobox 2.	Mesenchyme homeobox 1.	0.447
LOC102696492	meox2	ENSLOCP00000000497	ENSLOCP00000013854	Pre-B-cell leukemia homeobox 2.	Mesenchyme homeobox 2a.	0.447
LOC107078362	LOC102685540	ENSLOCP00000005315	ENSLOCP00000005278	PBC domain-containing protein.	Homeobox domain-containing protein.	0.760
LOC107078362	meox1	ENSLOCP00000005315	ENSLOCP00000014919	PBC domain-containing protein.	Mesenchyme homeobox 1.	0.447
LOC107078362	meox2	ENSLOCP00000005315	ENSLOCP00000013854	PBC domain-containing protein.	Mesenchyme homeobox 2a.	0.447
W5MIR5_LEPOC	meox1	ENSLOCP00000008274	ENSLOCP00000014919	Pre-B-cell leukemia transcription factor 4.	Mesenchyme homeobox 1.	0.447
W5MIR5_LEPOC	meox2	ENSLOCP00000008274	ENSLOCP00000013854	Pre-B-cell leukemia transcription factor 4.	Mesenchyme homeobox 2a.	0.447
meox1	LOC102685540	ENSLOCP00000014919	ENSLOCP00000005278	Mesenchyme homeobox 1.	Homeobox domain-containing protein.	0.447
meox1	LOC102690906	ENSLOCP00000014919	ENSLOCP00000007916	Mesenchyme homeobox 1.	T-box transcription factor 16.	0.446
meox1	LOC102690970	ENSLOCP00000014919	ENSLOCP00000003883	Mesenchyme homeobox 1.	Uncharacterized protein.	0.446
meox1	LOC102696492	ENSLOCP00000014919	ENSLOCP00000000497	Mesenchyme homeobox 1.	Pre-B-cell leukemia homeobox 2.	0.447
meox1	LOC107078362	ENSLOCP00000014919	ENSLOCP00000005315	Mesenchyme homeobox 1.	PBC domain-containing protein.	0.447
meox1	W5MIR5_LEPOC	ENSLOCP00000014919	ENSLOCP00000008274	Mesenchyme homeobox 1.	Pre-B-cell leukemia transcription factor 4.	0.447
meox1	meox2	ENSLOCP00000014919	ENSLOCP00000013854	Mesenchyme homeobox 1.	Mesenchyme homeobox 2a.	0.690
meox1	myog	ENSLOCP00000014919	ENSLOCP00000013138	Mesenchyme homeobox 1.	Myogenin.	0.427

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042176

Regulation of protein catabolic process

5 of 28

2.18

3.49

5.69e-08

GO:0010498

Proteasomal protein catabolic process

8 of 142

1.67

3.21

2.81e-10

GO:0051603

Proteolysis involved in protein catabolic process

10 of 235

1.55

3.09

5.48e-12

GO:0006511

Ubiquitin-dependent protein catabolic process

9 of 208

1.56

2.94

8.65e-11

GO:0043248

Proteasome assembly

4 of 19

2.25

2.88

1.98e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036402

Proteasome-activating activity

3 of 6

2.62

2.04

0.00017

GO:0004298

Threonine-type endopeptidase activity

2 of 5

2.53

0.92

0.0213

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000502

Proteasome complex

11 of 35

2.42

9.97

1.08e-23

GO:0005838

Proteasome regulatory particle

9 of 20

2.58

9.13

8.60e-20

GO:0008541

Proteasome regulatory particle, lid subcomplex

5 of 10

2.62

4.98

2.59e-10

GO:0008540

Proteasome regulatory particle, base subcomplex

4 of 9

2.57

3.75

7.23e-08

GO:0019774

Proteasome core complex, beta-subunit complex

2 of 7

2.38

1.33

0.0035

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1460

Proteasome complex

11 of 33

2.45

10.08

1.23e-23

CL:1461

Proteasome complex

8 of 28

2.38

6.99

7.87e-16

CL:1463

Proteasome accessory complex

6 of 14

2.56

5.77

3.82e-12

CL:1516

Proteasome regulatory particle, lid subcomplex

3 of 5

2.7

2.67

1.17e-05

CL:1466

Proteasome accessory complex

3 of 9

2.45

2.33

4.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03050

Proteasome

11 of 40

2.36

9.72

6.99e-24

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236978

Cross-presentation of soluble exogenous antigens (endosomes)

11 of 38

2.39

9.66

2.66e-23

MAP-1236975

Antigen processing-Cross presentation

11 of 39

2.37

9.6

2.66e-23

MAP-5689880

Ub-specific processing proteases

11 of 72

2.11

7.46

4.92e-21

MAP-5688426

Deubiquitination

11 of 101

1.96

6.29

1.20e-19

MAP-983169

Class I MHC mediated antigen processing & presentation

11 of 164

1.75

4.74

1.57e-17

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000502

Proteasome complex

11 of 81

2.06

6.92

5.10e-20

GOCC:0005838

Proteasome regulatory particle

4 of 16

2.32

3.06

1.03e-06

GOCC:0008540

Proteasome regulatory particle, base subcomplex

3 of 8

2.5

2.45

2.54e-05

GOCC:0019774

Proteasome core complex, beta-subunit complex

2 of 7

2.38

1.24

0.0051

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0647

Proteasome

5 of 22

2.28

3.83

1.62e-08

KW-0645

Protease

3 of 107

1.37

0.69

0.0312

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000717

Proteasome component (PCI) domain

5 of 17

2.39

3.68

5.95e-08

IPR036390

Winged helix DNA-binding domain superfamily

5 of 60

1.84

2.27

9.12e-06

IPR005937

26S proteasome regulatory subunit P45-like

3 of 6

2.62

2.17

9.68e-05

IPR003960

ATPase, AAA-type, conserved site

3 of 21

2.08

1.44

0.0017

IPR003959

ATPase, AAA-type, core

3 of 38

1.82

1.08

0.0072

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00088

Motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

5 of 13

2.51

4.43

2.27e-09

SM00753

PCI/PINT associated module

2 of 4

2.62

1.37

0.0031

SM00382

ATPases associated with a variety of cellular activities

3 of 99

1.4

0.76

0.0218

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