W5N2V4_LEPOC protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

W5N2V4_LEPOC

Uncharacterized protein. (541 aa)

Predicted Functional Partners:

rps27a

0.486

W5MSZ0_LEPOC

0.440

ube2l3

0.439

gas7

0.435

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
W5MSZ0_LEPOC	W5N2V4_LEPOC	ENSLOCP00000011499	ENSLOCP00000014963	Zinc finger, AN1-type domain 4.	Uncharacterized protein.	0.440
W5MSZ0_LEPOC	gas7	ENSLOCP00000011499	ENSLOCP00000014595	Zinc finger, AN1-type domain 4.	Growth arrest-specific 7a.	0.854
W5MSZ0_LEPOC	rps27a	ENSLOCP00000011499	ENSLOCP00000019146	Zinc finger, AN1-type domain 4.	Ribosomal protein S27a.	0.999
W5MSZ0_LEPOC	ube2l3	ENSLOCP00000011499	ENSLOCP00000002461	Zinc finger, AN1-type domain 4.	Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family.	0.736
W5N2V4_LEPOC	W5MSZ0_LEPOC	ENSLOCP00000014963	ENSLOCP00000011499	Uncharacterized protein.	Zinc finger, AN1-type domain 4.	0.440
W5N2V4_LEPOC	gas7	ENSLOCP00000014963	ENSLOCP00000014595	Uncharacterized protein.	Growth arrest-specific 7a.	0.435
W5N2V4_LEPOC	rps27a	ENSLOCP00000014963	ENSLOCP00000019146	Uncharacterized protein.	Ribosomal protein S27a.	0.486
W5N2V4_LEPOC	ube2l3	ENSLOCP00000014963	ENSLOCP00000002461	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family.	0.439
gas7	W5MSZ0_LEPOC	ENSLOCP00000014595	ENSLOCP00000011499	Growth arrest-specific 7a.	Zinc finger, AN1-type domain 4.	0.854
gas7	W5N2V4_LEPOC	ENSLOCP00000014595	ENSLOCP00000014963	Growth arrest-specific 7a.	Uncharacterized protein.	0.435
gas7	rps27a	ENSLOCP00000014595	ENSLOCP00000019146	Growth arrest-specific 7a.	Ribosomal protein S27a.	0.858
gas7	ube2l3	ENSLOCP00000014595	ENSLOCP00000002461	Growth arrest-specific 7a.	Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family.	0.418
rps27a	W5MSZ0_LEPOC	ENSLOCP00000019146	ENSLOCP00000011499	Ribosomal protein S27a.	Zinc finger, AN1-type domain 4.	0.999
rps27a	W5N2V4_LEPOC	ENSLOCP00000019146	ENSLOCP00000014963	Ribosomal protein S27a.	Uncharacterized protein.	0.486
rps27a	gas7	ENSLOCP00000019146	ENSLOCP00000014595	Ribosomal protein S27a.	Growth arrest-specific 7a.	0.858
rps27a	ube2l3	ENSLOCP00000019146	ENSLOCP00000002461	Ribosomal protein S27a.	Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family.	0.984
ube2l3	W5MSZ0_LEPOC	ENSLOCP00000002461	ENSLOCP00000011499	Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family.	Zinc finger, AN1-type domain 4.	0.736
ube2l3	W5N2V4_LEPOC	ENSLOCP00000002461	ENSLOCP00000014963	Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.439
ube2l3	gas7	ENSLOCP00000002461	ENSLOCP00000014595	Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family.	Growth arrest-specific 7a.	0.418
ube2l3	rps27a	ENSLOCP00000002461	ENSLOCP00000019146	Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family.	Ribosomal protein S27a.	0.984

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.84

expected number of edges:

13

PPI enrichment p-value:

0.00501

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016627

Oxidoreductase activity, acting on the CH-CH group of donors

6 of 32

1.75

2.58

4.74e-07

GO:0050660

Flavin adenine dinucleotide binding

6 of 34

1.72

2.53

4.74e-07

GO:0016491

Oxidoreductase activity

7 of 271

0.89

0.71

0.0016

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005622

Intracellular anatomical structure

10 of 1199

0.4

0.27

0.0451

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1502

Mixed, incl. Valine, leucine and isoleucine degradation, and Acyl-CoA dehydrogenase, middle domain

9 of 38

1.85

4.39

4.00e-13

CL:1503

Mixed, incl. Fatty acid degradation, and Acyl-CoA dehydrogenase, middle domain

8 of 29

1.92

4.39

3.58e-12

CL:1506

Benzoate degradation, and enoyl-CoA hydratase activity

6 of 17

2.02

3.74

3.51e-09

CL:1509

Benzoate degradation

3 of 10

1.95

1.63

0.00053

CL:1519

Enoyl-CoA hydratase/isomerase, conserved site, and Benzoate degradation

2 of 5

2.08

1.0

0.0131

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rpm00362

Benzoate degradation

3 of 12

1.87

1.43

0.0013

rpm00380

Tryptophan metabolism

2 of 12

1.7

0.68

0.0482

rpm00310

Lysine degradation

2 of 12

1.7

0.68

0.0482

rpm00071

Fatty acid degradation

2 of 13

1.66

0.67

0.0482

rpm01120

Microbial metabolism in diverse environments

4 of 172

0.84

0.45

0.0482

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005759

Mitochondrial matrix

6 of 23

1.89

3.17

3.53e-08

GOCC:0043229

Intracellular organelle

8 of 334

0.85

0.8

7.58e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0274

FAD

6 of 23

1.89

3.2

2.83e-08

KW-0560

Oxidoreductase

7 of 187

1.05

1.06

4.66e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08028

Acyl-CoA dehydrogenase, C-terminal domain

6 of 7

2.41

4.8

2.16e-10

PF02771

Acyl-CoA dehydrogenase, N-terminal domain

6 of 7

2.41

4.8

2.16e-10

PF02770

Acyl-CoA dehydrogenase, middle domain

6 of 7

2.41

4.8

2.16e-10

PF12806

Acetyl-CoA dehydrogenase C-terminal like

2 of 2

2.48

1.16

0.0074

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046373

Acyl-CoA oxidase/dehydrogenase, middle domain superfamily

6 of 7

2.41

4.61

5.87e-10

IPR037069

Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily

6 of 7

2.41

4.61

5.87e-10

IPR036250

Acyl-CoA dehydrogenase-like, C-terminal

6 of 7

2.41

4.61

5.87e-10

IPR013786

Acyl-CoA dehydrogenase/oxidase, N-terminal

6 of 7

2.41

4.61

5.87e-10

IPR009100

Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily

6 of 7

2.41

4.61

5.87e-10

(more ...)

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