STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppargc1aPeroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (833 aa)    
Predicted Functional Partners:
PPARG
Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]
   
 0.975
W5NK92_LEPOC
Peroxisome proliferator-activated receptor alpha a.
   
 0.975
crnkl1
Crooked neck pre-mRNA splicing factor 1.
   
 0.974
bud31
BUD31 homolog.
   
 0.972
W5MQR5_LEPOC
SNW domain containing 1.
   
 0.970
nr3c1
Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).
    
 0.960
sirt1
Sirtuin 1.
    
 0.959
isy1
ISY1 splicing factor homolog.
   
 0.957
nrf1
Nuclear respiratory factor 1.
   
 0.948
cwc15
CWC15 spliceosome associated protein homolog.
   
 
 0.943
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.