galt protein (Lepisosteus oculatus) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

galt

Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (367 aa)

Predicted Functional Partners:

gale

0.999

galk1

0.999

galk2

0.998

ugp2

0.994

galm

0.984

W5MG44_LEPOC

0.961

uap1

0.961

PGM1

0.930

pgm5

0.930

pgm3

0.915

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PGM1	W5MG44_LEPOC	ENSLOCP00000008053	ENSLOCP00000007353	Phosphoglucomutase 1.	UDP-N-acetylglucosamine pyrophosphorylase 1, like 1.	0.836
PGM1	gale	ENSLOCP00000008053	ENSLOCP00000002058	Phosphoglucomutase 1.	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	0.502
PGM1	galk1	ENSLOCP00000008053	ENSLOCP00000014092	Phosphoglucomutase 1.	Galactokinase 1.	0.659
PGM1	galk2	ENSLOCP00000008053	ENSLOCP00000016224	Phosphoglucomutase 1.	Galactokinase 2.	0.682
PGM1	galm	ENSLOCP00000008053	ENSLOCP00000019430	Phosphoglucomutase 1.	Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer.	0.878
PGM1	galt	ENSLOCP00000008053	ENSLOCP00000015236	Phosphoglucomutase 1.	Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.	0.930
PGM1	pgm3	ENSLOCP00000008053	ENSLOCP00000021098	Phosphoglucomutase 1.	Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family.	0.878
PGM1	uap1	ENSLOCP00000008053	ENSLOCP00000008676	Phosphoglucomutase 1.	UDP-N-acetylglucosamine pyrophosphorylase 1.	0.836
PGM1	ugp2	ENSLOCP00000008053	ENSLOCP00000019789	Phosphoglucomutase 1.	UTP--glucose-1-phosphate uridylyltransferase.	0.985
W5MG44_LEPOC	PGM1	ENSLOCP00000007353	ENSLOCP00000008053	UDP-N-acetylglucosamine pyrophosphorylase 1, like 1.	Phosphoglucomutase 1.	0.836
W5MG44_LEPOC	gale	ENSLOCP00000007353	ENSLOCP00000002058	UDP-N-acetylglucosamine pyrophosphorylase 1, like 1.	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	0.885
W5MG44_LEPOC	galk1	ENSLOCP00000007353	ENSLOCP00000014092	UDP-N-acetylglucosamine pyrophosphorylase 1, like 1.	Galactokinase 1.	0.770
W5MG44_LEPOC	galk2	ENSLOCP00000007353	ENSLOCP00000016224	UDP-N-acetylglucosamine pyrophosphorylase 1, like 1.	Galactokinase 2.	0.770
W5MG44_LEPOC	galm	ENSLOCP00000007353	ENSLOCP00000019430	UDP-N-acetylglucosamine pyrophosphorylase 1, like 1.	Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer.	0.712
W5MG44_LEPOC	galt	ENSLOCP00000007353	ENSLOCP00000015236	UDP-N-acetylglucosamine pyrophosphorylase 1, like 1.	Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.	0.961
W5MG44_LEPOC	pgm3	ENSLOCP00000007353	ENSLOCP00000021098	UDP-N-acetylglucosamine pyrophosphorylase 1, like 1.	Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family.	0.951
W5MG44_LEPOC	pgm5	ENSLOCP00000007353	ENSLOCP00000011436	UDP-N-acetylglucosamine pyrophosphorylase 1, like 1.	Phosphoglucomutase 5.	0.836
W5MG44_LEPOC	uap1	ENSLOCP00000007353	ENSLOCP00000008676	UDP-N-acetylglucosamine pyrophosphorylase 1, like 1.	UDP-N-acetylglucosamine pyrophosphorylase 1.	0.860
W5MG44_LEPOC	ugp2	ENSLOCP00000007353	ENSLOCP00000019789	UDP-N-acetylglucosamine pyrophosphorylase 1, like 1.	UTP--glucose-1-phosphate uridylyltransferase.	0.879
gale	PGM1	ENSLOCP00000002058	ENSLOCP00000008053	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	Phosphoglucomutase 1.	0.502

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Network Stats

number of nodes:

10

number of edges:

39

average node degree:

7.8

avg. local clustering coefficient:

0.95

expected number of edges:

10

PPI enrichment p-value:

2.96e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006644

Phospholipid metabolic process

5 of 350

1.42

1.15

0.0016

GO:0019637

Organophosphate metabolic process

7 of 816

1.2

1.1

0.00043

GO:0016042

Lipid catabolic process

4 of 245

1.47

0.99

0.0063

GO:0006629

Lipid metabolic process

7 of 1093

1.07

0.87

0.0016

GO:0044255

Cellular lipid metabolic process

6 of 848

1.11

0.86

0.0030

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004623

Phospholipase A2 activity

4 of 40

2.26

2.59

8.53e-06

GO:0016788

Hydrolase activity, acting on ester bonds

8 of 813

1.25

1.54

2.90e-06

GO:0004528

Phosphodiesterase I activity

2 of 5

2.86

1.5

0.0019

GO:0004551

Nucleotide diphosphatase activity

2 of 15

2.39

1.09

0.0097

GO:0008081

Phosphoric diester hydrolase activity

3 of 103

1.73

1.07

0.0066

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25342

Linoleic acid metabolism, and Glycerophospholipid catabolism

10 of 53

2.54

9.65

1.99e-21

CL:25343

Linoleic acid metabolism, and 1-alkyl-2-acetylglycerophosphocholine esterase complex

8 of 44

2.52

7.59

1.96e-16

CL:25345

Linoleic acid metabolism, and Synthesis of 15-eicosatetraenoic acid derivatives

6 of 33

2.52

5.48

1.37e-11

CL:25396

Phosphodiesterase I activity, and N-acylethanolamine metabolic process

3 of 5

3.04

2.92

4.78e-06

CL:25349

Mixed, incl. Icosanoid secretion, and Lipoxygenase

2 of 18

2.31

0.82

0.0309

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00565

Ether lipid metabolism

11 of 95

2.33

9.46

9.95e-24

map00592

alpha-Linolenic acid metabolism

6 of 43

2.41

5.45

6.77e-12

map00591

Linoleic acid metabolism

6 of 46

2.38

5.4

6.77e-12

map00590

Arachidonic acid metabolism

6 of 94

2.07

4.23

2.28e-10

map00564

Glycerophospholipid metabolism

7 of 207

1.79

3.57

2.17e-10

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1482788

Acyl chain remodelling of PC

4 of 42

2.24

2.5

1.29e-05

MAP-1483206

Glycerophospholipid biosynthesis

5 of 201

1.66

1.92

2.60e-05

MAP-1483257

Phospholipid metabolism

6 of 338

1.51

1.83

1.29e-05

MAP-1482839

Acyl chain remodelling of PE

3 of 43

2.11

1.61

0.00075

MAP-196843

Vitamin B2 (riboflavin) metabolism

2 of 12

2.48

1.22

0.0058

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01663

Type I phosphodiesterase / nucleotide pyrophosphatase

3 of 12

2.66

2.13

0.00012

PF06951

Group XII secretory phospholipase A2 precursor (PLA2G12)

2 of 3

3.09

1.4

0.0030

PF04970

Lecithin retinol acyltransferase

2 of 12

2.48

0.95

0.0181

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00201

Somatomedin B -like domains

2 of 8

2.66

1.13

0.0090

SM00477

DNA/RNA non-specific endonuclease

2 of 14

2.42

1.05

0.0120

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