STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (522 aa)    
Predicted Functional Partners:
NCSTN
Nicastrin.
   
 0.992
notch1
Notch receptor 1a.
    
 0.975
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 0.960
APH1A
Aph-1 homolog A, gamma-secretase subunit.
   
 0.936
LOC102689245
Zgc:114200.
   
 0.936
LOC102694001
APH1B gamma secretase subunit.
   
 0.936
gsk3b
Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily.
    
 0.935
W5MJS7_LEPOC
Notch receptor 3.
    
 0.892
W5MVW5_LEPOC
Notch receptor 2.
    
 0.892
W5MXT3_LEPOC
Amyloid beta (A4) precursor protein b.
    
 
 0.884
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.