helt protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

helt

Helt bHLH transcription factor. (235 aa)

Predicted Functional Partners:

W5MHY9_LEPOC

0.642

W5MSG4_LEPOC

0.601

fancl

0.601

tal2

0.585

W5LWN7_LEPOC

0.508

rpl10a

0.508

RPL10A

0.508

FANCA

0.504

nutf2

0.504

LOC102691293

0.504

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FANCA	RPL10A	ENSLOCP00000003425	ENSLOCP00000014298	FA complementation group A.	Ribosomal protein L10a.	0.956
FANCA	W5LWN7_LEPOC	ENSLOCP00000003425	ENSLOCP00000000544	FA complementation group A.	FA complementation group E.	0.978
FANCA	W5MHY9_LEPOC	ENSLOCP00000003425	ENSLOCP00000007998	FA complementation group A.	FA complementation group G.	0.999
FANCA	W5MSG4_LEPOC	ENSLOCP00000003425	ENSLOCP00000011323	FA complementation group A.	FA complementation group C.	0.998
FANCA	fancl	ENSLOCP00000003425	ENSLOCP00000019883	FA complementation group A.	FA complementation group L.	0.998
FANCA	helt	ENSLOCP00000003425	ENSLOCP00000016976	FA complementation group A.	Helt bHLH transcription factor.	0.504
FANCA	rpl10a	ENSLOCP00000003425	ENSLOCP00000000590	FA complementation group A.	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	0.956
LOC102691293	RPL10A	ENSLOCP00000010193	ENSLOCP00000014298	Nuclear transport factor 2, like.	Ribosomal protein L10a.	0.835
LOC102691293	W5LWN7_LEPOC	ENSLOCP00000010193	ENSLOCP00000000544	Nuclear transport factor 2, like.	FA complementation group E.	0.835
LOC102691293	W5MHY9_LEPOC	ENSLOCP00000010193	ENSLOCP00000007998	Nuclear transport factor 2, like.	FA complementation group G.	0.964
LOC102691293	W5MSG4_LEPOC	ENSLOCP00000010193	ENSLOCP00000011323	Nuclear transport factor 2, like.	FA complementation group C.	0.952
LOC102691293	fancl	ENSLOCP00000010193	ENSLOCP00000019883	Nuclear transport factor 2, like.	FA complementation group L.	0.952
LOC102691293	helt	ENSLOCP00000010193	ENSLOCP00000016976	Nuclear transport factor 2, like.	Helt bHLH transcription factor.	0.504
LOC102691293	nutf2	ENSLOCP00000010193	ENSLOCP00000008132	Nuclear transport factor 2, like.	Nuclear transport factor 2.	0.548
LOC102691293	rpl10a	ENSLOCP00000010193	ENSLOCP00000000590	Nuclear transport factor 2, like.	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	0.835
RPL10A	FANCA	ENSLOCP00000014298	ENSLOCP00000003425	Ribosomal protein L10a.	FA complementation group A.	0.956
RPL10A	LOC102691293	ENSLOCP00000014298	ENSLOCP00000010193	Ribosomal protein L10a.	Nuclear transport factor 2, like.	0.835
RPL10A	W5LWN7_LEPOC	ENSLOCP00000014298	ENSLOCP00000000544	Ribosomal protein L10a.	FA complementation group E.	0.440
RPL10A	W5MHY9_LEPOC	ENSLOCP00000014298	ENSLOCP00000007998	Ribosomal protein L10a.	FA complementation group G.	0.931
RPL10A	W5MSG4_LEPOC	ENSLOCP00000014298	ENSLOCP00000011323	Ribosomal protein L10a.	FA complementation group C.	0.951

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.817

expected number of edges:

16

PPI enrichment p-value:

9.53e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046486

Glycerolipid metabolic process

6 of 179

1.9

2.95

1.81e-07

GO:0006629

Lipid metabolic process

8 of 742

1.41

2.03

1.81e-07

GO:0055091

Phospholipid homeostasis

2 of 2

3.38

1.84

0.00049

GO:0045017

Glycerolipid biosynthetic process

4 of 139

1.84

1.72

0.00024

GO:0140042

Lipid droplet formation

2 of 4

3.08

1.67

0.00096

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008374

O-acyltransferase activity

4 of 35

2.44

2.95

2.27e-06

GO:0102545

Phosphatidyl phospholipase B activity

2 of 2

3.38

1.88

0.00041

GO:0046027

Phospholipid:diacylglycerol acyltransferase activity

2 of 2

3.38

1.88

0.00041

GO:0003841

1-acylglycerol-3-phosphate O-acyltransferase activity

2 of 3

3.2

1.87

0.00043

GO:0004620

Phospholipase activity

3 of 36

2.3

1.79

0.00041

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0097038

Perinuclear endoplasmic reticulum

2 of 8

2.78

1.32

0.0040

GO:0032541

Cortical endoplasmic reticulum

2 of 14

2.53

1.31

0.0040

GO:0005637

Nuclear inner membrane

2 of 13

2.57

1.31

0.0040

GO:0005811

Lipid droplet

2 of 53

1.96

0.9

0.0195

GO:0019866

Organelle inner membrane

3 of 319

1.35

0.76

0.0205

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20219

Glycerophospholipid metabolism, and Fatty acid biosynthesis

7 of 106

2.2

4.89

1.99e-11

CL:20220

Glycerophospholipid metabolism, and Fatty acid biosynthesis

5 of 88

2.13

3.14

3.08e-07

CL:20221

Mixed, incl. Triglyceride metabolic process, and Phosphate acyltransferases

4 of 52

2.26

2.68

5.48e-06

CL:20236

1-acylglycerol-3-phosphate O-acyltransferase activity, and Glycerophosphodiester phosphodiesterase domain

2 of 5

2.98

1.46

0.0023

CL:20400

Animal haem peroxidase, and Acyl chain remodelling of PC

2 of 6

2.9

1.45

0.0024

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00564

Glycerophospholipid metabolism

6 of 186

1.89

3.34

9.50e-09

map00561

Glycerolipid metabolism

4 of 106

1.96

2.42

7.09e-06

map00565

Ether lipid metabolism

2 of 63

1.88

0.92

0.0165

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1482788

Acyl chain remodelling of PC

4 of 10

2.98

4.4

7.86e-09

MAP-1483257

Phospholipid metabolism

7 of 159

2.02

4.25

1.08e-10

MAP-1482839

Acyl chain remodelling of PE

4 of 14

2.83

4.19

1.60e-08

MAP-1483206

Glycerophospholipid biosynthesis

5 of 90

2.12

3.42

5.96e-08

MAP-1482801

Acyl chain remodelling of PS

3 of 7

3.01

3.28

1.03e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005783

Endoplasmic reticulum

6 of 367

1.59

2.09

3.48e-06

GOCC:0097038

Perinuclear endoplasmic reticulum

2 of 14

2.53

1.2

0.0065

GOCC:0005737

Cytoplasm

8 of 4349

0.64

0.43

0.0148

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0443

Lipid metabolism

4 of 38

2.4

3.27

4.44e-07

KW-0442

Lipid degradation

3 of 9

2.9

3.18

1.44e-06

KW-1133

Transmembrane helix

9 of 3683

0.77

0.7

7.08e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02450

Lecithin:cholesterol acyltransferase

2 of 2

3.38

1.6

0.0013

PF01734

Patatin-like phospholipase

2 of 3

3.2

1.6

0.0013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016035

Acyl transferase/acyl hydrolase/lysophospholipase

3 of 9

2.9

2.39

4.44e-05

IPR003386

Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase

2 of 2

3.38

1.53

0.0018

IPR002641

Patatin-like phospholipase domain

2 of 3

3.2

1.5

0.0020

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