STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1321 aa)    
Predicted Functional Partners:
npc2
Niemann-Pick disease, type C2.
    
 0.984
W5N1W4_LEPOC
Sterol regulatory element binding transcription factor 2.
   
 0.846
W5MQL4_LEPOC
Sterol regulatory element binding transcription factor 1.
   
 0.842
mycn
MYCN proto-oncogene, bHLH transcription factor.
   
 0.793
osbpl5
Oxysterol-binding protein; Belongs to the OSBP family.
   
 0.728
OSBPL8
Oxysterol-binding protein; Belongs to the OSBP family.
   
 0.728
insig1
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.
   
 0.691
INSIG2
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
   
 0.682
osbpl10
Oxysterol-binding protein; Belongs to the OSBP family.
   
 0.572
osbpl11
Oxysterol-binding protein; Belongs to the OSBP family.
   
 0.572
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.