LOC102698058 protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC102698058

Hexokinase 2. (923 aa)

Predicted Functional Partners:

W5MJC8_LEPOC

0.945

gckr

0.919

W5M225_LEPOC

0.875

gnpnat1

0.849

PGM1

0.848

W5MXU9_LEPOC

0.847

tigar

0.844

mpi

0.838

sord

0.837

W5LV49_LEPOC

0.831

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102698058	PGM1	ENSLOCP00000018843	ENSLOCP00000008053	Hexokinase 2.	Phosphoglucomutase 1.	0.848
LOC102698058	W5LV49_LEPOC	ENSLOCP00000018843	ENSLOCP00000000006	Hexokinase 2.	Transaldolase 1.	0.831
LOC102698058	W5M225_LEPOC	ENSLOCP00000018843	ENSLOCP00000002433	Hexokinase 2.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.875
LOC102698058	W5MJC8_LEPOC	ENSLOCP00000018843	ENSLOCP00000008487	Hexokinase 2.	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase).	0.945
LOC102698058	W5MXU9_LEPOC	ENSLOCP00000018843	ENSLOCP00000013208	Hexokinase 2.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.847
LOC102698058	gckr	ENSLOCP00000018843	ENSLOCP00000020702	Hexokinase 2.	Uncharacterized protein.	0.919
LOC102698058	gnpnat1	ENSLOCP00000018843	ENSLOCP00000014863	Hexokinase 2.	Glucosamine 6-phosphate N-acetyltransferase.	0.849
LOC102698058	mpi	ENSLOCP00000018843	ENSLOCP00000018394	Hexokinase 2.	Mannose-6-phosphate isomerase.	0.838
LOC102698058	sord	ENSLOCP00000018843	ENSLOCP00000016922	Hexokinase 2.	Sorbitol dehydrogenase.	0.837
LOC102698058	tigar	ENSLOCP00000018843	ENSLOCP00000020596	Hexokinase 2.	TP53 induced glycolysis regulatory phosphatase a.	0.844
PGM1	LOC102698058	ENSLOCP00000008053	ENSLOCP00000018843	Phosphoglucomutase 1.	Hexokinase 2.	0.848
PGM1	W5LV49_LEPOC	ENSLOCP00000008053	ENSLOCP00000000006	Phosphoglucomutase 1.	Transaldolase 1.	0.959
PGM1	W5M225_LEPOC	ENSLOCP00000008053	ENSLOCP00000002433	Phosphoglucomutase 1.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.990
PGM1	W5MJC8_LEPOC	ENSLOCP00000008053	ENSLOCP00000008487	Phosphoglucomutase 1.	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase).	0.981
PGM1	W5MXU9_LEPOC	ENSLOCP00000008053	ENSLOCP00000013208	Phosphoglucomutase 1.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.546
PGM1	mpi	ENSLOCP00000008053	ENSLOCP00000018394	Phosphoglucomutase 1.	Mannose-6-phosphate isomerase.	0.452
PGM1	sord	ENSLOCP00000008053	ENSLOCP00000016922	Phosphoglucomutase 1.	Sorbitol dehydrogenase.	0.909
W5LV49_LEPOC	LOC102698058	ENSLOCP00000000006	ENSLOCP00000018843	Transaldolase 1.	Hexokinase 2.	0.831
W5LV49_LEPOC	PGM1	ENSLOCP00000000006	ENSLOCP00000008053	Transaldolase 1.	Phosphoglucomutase 1.	0.959
W5LV49_LEPOC	W5M225_LEPOC	ENSLOCP00000000006	ENSLOCP00000002433	Transaldolase 1.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.985

page 1 of 5

Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.331

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006893

Golgi to plasma membrane transport

8 of 31

2.63

8.09

5.02e-17

GO:0006887

Exocytosis

11 of 152

2.08

6.95

1.53e-19

GO:0090522

Vesicle tethering involved in exocytosis

3 of 3

3.22

3.13

2.11e-06

GO:0140029

Exocytic process

4 of 47

2.15

2.52

9.07e-06

GO:2000535

Regulation of entry of bacterium into host cell

2 of 5

2.82

1.46

0.0022

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031267

Small GTPase binding

6 of 213

1.67

2.23

2.99e-06

GO:0047485

Protein N-terminus binding

3 of 44

2.06

1.38

0.0022

GO:0005546

phosphatidylinositol-4,5-bisphosphate binding

3 of 51

1.99

1.34

0.0025

GO:0035091

Phosphatidylinositol binding

4 of 213

1.5

1.11

0.0030

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000145

Exocyst

11 of 17

3.03

14.82

1.34e-29

GO:0090543

Flemming body

3 of 15

2.52

2.4

3.23e-05

GO:0030496

Midbody

4 of 107

1.79

1.9

7.18e-05

GO:0032584

Growth cone membrane

2 of 6

2.74

1.58

0.0013

GO:0030426

Growth cone

3 of 62

1.91

1.47

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20165

Exocyst

11 of 11

3.22

15.74

1.37e-30

CL:20168

Exocyst

6 of 6

3.22

7.89

2.82e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05132

Salmonella infection

4 of 262

1.41

1.09

0.0025

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-264876

Insulin processing

11 of 27

2.83

13.33

1.00e-27

MAP-5620916

VxPx cargo-targeting to cilium

11 of 36

2.71

12.49

7.25e-27

MAP-5620920

Cargo trafficking to the periciliary membrane

11 of 61

2.48

10.64

8.39e-25

MAP-2980736

Peptide hormone metabolism

11 of 87

2.32

9.34

2.33e-23

MAP-5617833

Cilium Assembly

11 of 248

1.87

5.58

1.18e-18

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000145

Exocyst

7 of 16

2.86

7.87

8.68e-16

GOCC:0071944

Cell periphery

9 of 2215

0.83

0.76

9.08e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0268

Exocytosis

4 of 6

3.05

4.53

4.79e-09

KW-0813

Transport

4 of 641

1.02

0.53

0.0446

KW-0175

Coiled coil

8 of 3376

0.6

0.39

0.0210

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09763

Exocyst complex component Sec3

2 of 2

3.22

1.33

0.0041

PF04091

Exocyst complex subunit Sec15-like

2 of 2

3.22

1.33

0.0041

PF06046

Exocyst complex component Sec6

2 of 6

2.74

1.21

0.0064

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046361

Exocyst complex subunit Sec15, C-terminal

2 of 2

3.22

1.05

0.0130

IPR042045

Exocyst complex component EXOC6/Sec15, C-terminal, domain 1

2 of 2

3.22

1.05

0.0130

IPR042044

EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2

2 of 3

3.05

1.05

0.0130

IPR019160

Exocyst complex component Sec3, C-terminal

2 of 2

3.22

1.05

0.0130

IPR007225

Exocyst complex component EXOC6/Sec15

2 of 2

3.22

1.05

0.0130

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01313

Exocyst complex component SEC3 N-terminal PIP2 binding PH

2 of 4

2.92

1.34

0.0037

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About