LOC102689647 protein (Lepisosteus oculatus) - STRING interaction network

[ The below analysis is limited to the network nodes included in the specified statistical background ]

Network Stats

number of nodes:

number of edges:

average node degree:

2.91

avg. local clustering coefficient:

0.876

expected number of edges:

PPI enrichment p-value:

0.123

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031386

Protein tag

2 of 13

2.96

1.72

0.0060

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:38507

Mixed, incl. Myelin basic protein, and Vitellinogen, beta-sheet shell

2 of 5

3.37

2.06

0.0023

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-975163

IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

2 of 12

2.99

2.03

0.0024

MAP-9708530

Regulation of BACH1 activity

2 of 11

3.03

2.03

0.0024

MAP-937042

IRAK2 mediated activation of TAK1 complex

2 of 12

2.99

2.03

0.0024

MAP-8948747

Regulation of PTEN localization

2 of 10

3.07

2.03

0.0024

MAP-3134975

Regulation of innate immune responses to cytosolic DNA

2 of 12

2.99

2.03

0.0024

MAP-9664873

Pexophagy

2 of 16

2.87

2.02

0.0024

MAP-937072

TRAF6-mediated induction of TAK1 complex within TLR4 complex

2 of 13

2.96

2.02

0.0024

MAP-8866427

VLDLR internalisation and degradation

2 of 16

2.87

2.02

0.0024

MAP-8849469

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

2 of 14

2.93

2.02

0.0024

MAP-5689877

Josephin domain DUBs

2 of 14

2.93

2.02

0.0024

MAP-2122948

Activated NOTCH1 Transmits Signal to the Nucleus

2 of 16

2.87

2.02

0.0024

MAP-209560

NF-kB is activated and signals survival

2 of 14

2.93

2.02

0.0024

MAP-209543

p75NTR recruits signalling complexes

2 of 13

2.96

2.02

0.0024

MAP-205043

NRIF signals cell death from the nucleus

2 of 13

2.96

2.02

0.0024

MAP-174113

SCF-beta-TrCP mediated degradation of Emi1

2 of 14

2.93

2.02

0.0024

MAP-1253288

Downregulation of ERBB4 signaling

2 of 13

2.96

2.02

0.0024

MAP-2173791

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

2 of 19

2.79

2.01

0.0024

MAP-2173788

Downregulation of TGF-beta receptor signaling

2 of 17

2.84

2.01

0.0024

MAP-193639

p75NTR signals via NF-kB

2 of 17

2.84

2.01

0.0024

MAP-1295596

Spry regulation of FGF signaling

2 of 20

2.77

2.01

0.0024

MAP-4641263

Regulation of FZD by ubiquitination

2 of 22

2.73

2.0

0.0024

MAP-110312

Translesion synthesis by REV1

2 of 24

2.69

2.0

0.0024

MAP-901032

ER Quality Control Compartment (ERQC)

2 of 26

2.66

1.99

0.0024

MAP-5656121

Translesion synthesis by POLI

2 of 25

2.67

1.99

0.0024

MAP-5655862

Translesion synthesis by POLK

2 of 25

2.67

1.99

0.0024

MAP-450321

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

2 of 26

2.66

1.99

0.0024

MAP-450302

Activated TAK1 mediates p38 MAPK activation

2 of 27

2.64

1.99

0.0024

MAP-2173795

Downregulation of SMAD2/3:SMAD4 transcriptional activity

2 of 26

2.66

1.99

0.0024

MAP-9648002

RAS processing

2 of 32

2.57

1.98

0.0024

MAP-912631

Regulation of signaling by CBL

2 of 29

2.61

1.98

0.0024

MAP-6807004

Negative regulation of MET activity

2 of 31

2.58

1.98

0.0024

MAP-5696397

Gap-filling DNA repair synthesis and ligation in GG-NER

2 of 32

2.57

1.98

0.0024

MAP-5654733

Negative regulation of FGFR4 signaling

2 of 33

2.55

1.98

0.0024

MAP-5654732

Negative regulation of FGFR3 signaling

2 of 31

2.58

1.98

0.0024

MAP-1980143

Signaling by NOTCH1

2 of 32

2.57

1.98

0.0024

MAP-174048

APC/C:Cdc20 mediated degradation of Cyclin B

2 of 32

2.57

1.98

0.0024

MAP-110320

Translesion Synthesis by POLH

2 of 30

2.59

1.98

0.0024

MAP-901042

Calnexin/calreticulin cycle

2 of 34

2.54

1.97

0.0024

MAP-8863795

Downregulation of ERBB2 signaling

2 of 34

2.54

1.97

0.0024

MAP-5675482

Regulation of necroptotic cell death

2 of 34

2.54

1.97

0.0024

MAP-5213460

RIPK1-mediated regulated necrosis

2 of 34

2.54

1.97

0.0024

MAP-2173796

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

2 of 35

2.53

1.97

0.0024

MAP-179409

APC-Cdc20 mediated degradation of Nek2A

2 of 35

2.53

1.97

0.0024

MAP-8866652

Synthesis of active ubiquitin: roles of E1 and E2 enzymes

2 of 39

2.48

1.96

0.0024

MAP-6783310

Fanconi Anemia Pathway

2 of 41

2.46

1.96

0.0024

MAP-5689896

Ovarian tumor domain proteases

2 of 40

2.47

1.96

0.0024

MAP-5654727

Negative regulation of FGFR2 signaling

2 of 39

2.48

1.96

0.0024

MAP-5654726

Negative regulation of FGFR1 signaling

2 of 38

2.49

1.96

0.0024

MAP-5357956

TNFR1-induced NFkappaB signaling pathway

2 of 41

2.46

1.96

0.0024

MAP-182971

EGFR downregulation

2 of 41

2.46

1.96

0.0024

MAP-168638

NOD1/2 Signaling Pathway

2 of 39

2.48

1.96

0.0024

MAP-110314

Recognition of DNA damage by PCNA-containing replication complex

2 of 40

2.47

1.96

0.0024

MAP-9646399

Aggrephagy

2 of 46

2.41

1.95

0.0024

MAP-6806003

Regulation of TP53 Expression and Degradation

2 of 46

2.41

1.95

0.0024

MAP-6804757

Regulation of TP53 Degradation

2 of 43

2.44

1.95

0.0024

MAP-5654743

Signaling by FGFR4

2 of 45

2.42

1.95

0.0024

MAP-5654741

Signaling by FGFR3

2 of 45

2.42

1.95

0.0024

MAP-532668

N-glycan trimming in the ER and Calnexin/Calreticulin cycle

2 of 44

2.43

1.95

0.0024

MAP-512988

Interleukin-3, Interleukin-5 and GM-CSF signaling

2 of 42

2.45

1.95

0.0024

MAP-176408

Regulation of APC/C activators between G1/S and early anaphase

2 of 46

2.41

1.95

0.0024

MAP-917729

Endosomal Sorting Complex Required For Transport (ESCRT)

2 of 48

2.39

1.94

0.0024

MAP-5696400

Dual Incision in GG-NER

2 of 49

2.38

1.94

0.0024

MAP-5696394

DNA Damage Recognition in GG-NER

2 of 48

2.39

1.94

0.0024

MAP-2173789

TGF-beta receptor signaling activates SMADs

2 of 48

2.39

1.94

0.0024

MAP-202424

Downstream TCR signaling

2 of 47

2.4

1.94

0.0024

MAP-1834949

Cytosolic sensors of pathogen-associated DNA

2 of 48

2.39

1.94

0.0024

MAP-9762114

GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

2 of 55

2.33

1.93

0.0024

MAP-8852276

The role of GTSE1 in G2/M progression after G2 checkpoint

2 of 51

2.36

1.93

0.0024

MAP-75815

Ubiquitin-dependent degradation of Cyclin D

2 of 53

2.35

1.93

0.0024

MAP-69613

p53-Independent G1/S DNA damage checkpoint

2 of 54

2.34

1.93

0.0024

MAP-69610

p53-Independent DNA Damage Response

2 of 54

2.34

1.93

0.0024

MAP-69601

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

2 of 54

2.34

1.93

0.0024

MAP-5218859

Regulated Necrosis

2 of 51

2.36

1.93

0.0024

MAP-1236394

Signaling by ERBB4

2 of 51

2.36

1.93

0.0024

MAP-8964043

Plasma lipoprotein clearance

2 of 56

2.32

1.92

0.0024

MAP-5696395

Formation of Incision Complex in GG-NER

2 of 57

2.32

1.92

0.0024

MAP-5610780

Degradation of GLI1 by the proteasome

2 of 59

2.3

1.92

0.0024

MAP-4641257

Degradation of AXIN

2 of 59

2.3

1.92

0.0024

MAP-3769402

Deactivation of the beta-catenin transactivating complex

2 of 56

2.32

1.92

0.0024

MAP-349425

Autodegradation of the E3 ubiquitin ligase COP1

2 of 56

2.32

1.92

0.0024

MAP-8941858

Regulation of RUNX3 expression and activity

2 of 60

2.29

1.91

0.0024

MAP-8939902

Regulation of RUNX2 expression and activity

2 of 62

2.28

1.91

0.0024

MAP-8866654

E3 ubiquitin ligases ubiquitinate target proteins

2 of 61

2.29

1.91

0.0024

MAP-8854050

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

2 of 61

2.29

1.91

0.0024

MAP-69541

Stabilization of p53

2 of 61

2.29

1.91

0.0024

MAP-69236

G1 Phase

2 of 63

2.27

1.91

0.0024

MAP-69231

Cyclin D associated events in G1

2 of 63

2.27

1.91

0.0024

MAP-6781823

Formation of TC-NER Pre-Incision Complex

2 of 60

2.29

1.91

0.0024

MAP-5654736

Signaling by FGFR1

2 of 61

2.29

1.91

0.0024

MAP-5610785

GLI3 is processed to GLI3R by the proteasome

2 of 63

2.27

1.91

0.0024

MAP-4641258

Degradation of DVL

2 of 60

2.29

1.91

0.0024

MAP-450408

AUF1 (hnRNP D0) binds and destabilizes mRNA

2 of 64

2.27

1.91

0.0024

MAP-2173793

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

2 of 64

2.27

1.91

0.0024

MAP-1227986

Signaling by ERBB2

2 of 60

2.29

1.91

0.0024

MAP-9759194

Nuclear events mediated by NFE2L2

2 of 66

2.25

1.9

0.0024

MAP-5676590

NIK-->noncanonical NF-kB signaling

2 of 65

2.26

1.9

0.0024

MAP-5607761

Dectin-1 mediated noncanonical NF-kB signaling

2 of 65

2.26

1.9

0.0024

MAP-187577

SCF(Skp2)-mediated degradation of p27/p21

2 of 68

2.24

1.9

0.0024

MAP-177929

Signaling by EGFR

2 of 68

2.24

1.9

0.0024

MAP-9006927

Signaling by Non-Receptor Tyrosine Kinases

2 of 70

2.23

1.89

0.0024

MAP-8848021

Signaling by PTK6

2 of 70

2.23

1.89

0.0024

MAP-5685942

HDR through Homologous Recombination (HRR)

2 of 69

2.23

1.89

0.0024

MAP-5675221

Negative regulation of MAPK pathway

2 of 69

2.23

1.89

0.0024

MAP-5656169

Termination of translesion DNA synthesis

2 of 70

2.23

1.89

0.0024

MAP-5357905

Regulation of TNFR1 signaling

2 of 70

2.23

1.89

0.0024

MAP-4608870

Asymmetric localization of PCP proteins

2 of 70

2.23

1.89

0.0024

MAP-450294

MAP kinase activation

2 of 71

2.22

1.89

0.0024

MAP-202403

TCR signaling

2 of 70

2.23

1.89

0.0024

MAP-168643

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

2 of 70

2.23

1.89

0.0024

MAP-157118

Signaling by NOTCH

2 of 69

2.23

1.89

0.0024

MAP-1234176

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

2 of 69

2.23

1.89

0.0024

MAP-1169091

Activation of NF-kappaB in B cells

2 of 69

2.23

1.89

0.0024

MAP-8939236

RUNX1 regulates transcription of genes involved in differentiation of HSCs

2 of 76

2.19

1.88

0.0024

MAP-69580

p53-Dependent G1/S DNA damage checkpoint

2 of 76

2.19

1.88

0.0024

MAP-69563

p53-Dependent G1 DNA Damage Response

2 of 76

2.19

1.88

0.0024

MAP-68949

Orc1 removal from chromatin

2 of 75

2.2

1.88

0.0024

MAP-448424

Interleukin-17 signaling

2 of 78

2.18

1.88

0.0024

MAP-174084

Autodegradation of Cdh1 by Cdh1:APC/C

2 of 74

2.2

1.88

0.0024

MAP-1234174

Cellular response to hypoxia

2 of 74

2.2

1.88

0.0024

MAP-110313

Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

2 of 78

2.18

1.88

0.0024

MAP-75893

TNF signaling

2 of 82

2.16

1.87

0.0024

MAP-69615

G1/S DNA Damage Checkpoints

2 of 79

2.17

1.87

0.0024

MAP-5654738

Signaling by FGFR2

2 of 83

2.15

1.87

0.0024

MAP-5358346

Hedgehog ligand biogenesis

2 of 80

2.17

1.87

0.0024

MAP-204998

Cell death signalling via NRAGE, NRIF and NADE

2 of 81

2.16

1.87

0.0024

MAP-174154

APC/C:Cdc20 mediated degradation of Securin

2 of 79

2.17

1.87

0.0024

MAP-73893

DNA Damage Bypass

2 of 86

2.14

1.86

0.0024

MAP-69656

Cyclin A:Cdk2-associated events at S phase entry

2 of 86

2.14

1.86

0.0024

MAP-69202

Cyclin E associated events during G1/S transition

2 of 84

2.15

1.86

0.0024

MAP-69017

CDK-mediated phosphorylation and removal of Cdc6

2 of 84

2.15

1.86

0.0024

MAP-6806834

Signaling by MET

2 of 85

2.14

1.86

0.0024

MAP-6782210

Gap-filling DNA repair synthesis and ligation in TC-NER

2 of 84

2.15

1.86

0.0024

MAP-6782135

Dual incision in TC-NER

2 of 87

2.13

1.86

0.0024

MAP-179419

APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint

2 of 86

2.14

1.86

0.0024

MAP-174184

Cdc20:Phospho-APC/C mediated degradation of Cyclin A

2 of 85

2.14

1.86

0.0024

MAP-174178

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

2 of 86

2.14

1.86

0.0024

MAP-8852135

Protein ubiquitination

2 of 88

2.13

1.85

0.0024

MAP-5668541

TNFR2 non-canonical NF-kB pathway

2 of 92

2.11

1.85

0.0024

MAP-176814

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

2 of 88

2.13

1.85

0.0024

MAP-176409

APC/C:Cdc20 mediated degradation of mitotic proteins

2 of 88

2.13

1.85

0.0024

MAP-1168372

Downstream signaling events of B Cell Receptor (BCR)

2 of 90

2.12

1.85

0.0024

MAP-9663891

Selective autophagy

2 of 93

2.1

1.84

0.0024

MAP-8878166

Transcriptional regulation by RUNX2

2 of 95

2.09

1.84

0.0024

MAP-8878159

Transcriptional regulation by RUNX3

2 of 97

2.09

1.84

0.0024

MAP-5632684

Hedgehog on state

2 of 96

2.09

1.84

0.0024

MAP-195253

Degradation of beta-catenin by the destruction complex

2 of 93

2.1

1.84

0.0024

MAP-6781827

Transcription-Coupled Nucleotide Excision Repair (TC-NER)

2 of 98

2.08

1.83

0.0024

MAP-453276

Regulation of mitotic cell cycle

2 of 101

2.07

1.83

0.0024

MAP-174824

Plasma lipoprotein assembly, remodeling, and clearance

2 of 100

2.07

1.83

0.0024

MAP-174143

APC/C-mediated degradation of cell cycle proteins

2 of 101

2.07

1.83

0.0024

MAP-9755511

KEAP1-NFE2L2 pathway

2 of 103

2.06

1.82

0.0024

MAP-9033241

Peroxisomal protein import

2 of 105

2.05

1.82

0.0024

MAP-8948751

Regulation of PTEN stability and activity

2 of 105

2.05

1.82

0.0024

MAP-69052

Switching of origins to a post-replicative state

2 of 103

2.06

1.82

0.0024

MAP-5696399

Global Genome Nucleotide Excision Repair (GG-NER)

2 of 107

2.04

1.82

0.0024

MAP-4086400

PCP/CE pathway

2 of 107

2.04

1.82

0.0024

MAP-917937

Iron uptake and transport

2 of 108

2.04

1.81

0.0024

MAP-5607764

CLEC7A (Dectin-1) signaling

2 of 111

2.03

1.81

0.0024

MAP-2559582

Senescence-Associated Secretory Phenotype (SASP)

2 of 112

2.02

1.81

0.0024

MAP-193704

p75 NTR receptor-mediated signalling

2 of 108

2.04

1.81

0.0024

MAP-190236

Signaling by FGFR

2 of 109

2.03

1.81

0.0024

MAP-170834

Signaling by TGF-beta Receptor Complex

2 of 112

2.02

1.81

0.0024

MAP-9758274

Regulation of NF-kappa B signaling

2 of 119

2.0

1.79

0.0024

MAP-5689901

Metalloprotease DUBs

2 of 120

1.99

1.79

0.0024

MAP-5689603

UCH proteinases

2 of 122

1.99

1.79

0.0024

MAP-450531

Regulation of mRNA stability by proteins that bind AU-rich elements

2 of 119

2.0

1.79

0.0024

MAP-382556

ABC-family proteins mediated transport

2 of 120

1.99

1.79

0.0024

MAP-2565942

Regulation of PLK1 Activity at G2/M Transition

2 of 119

2.0

1.79

0.0024

MAP-69206

G1/S Transition

2 of 130

1.96

1.77

0.0024

MAP-5610787

Hedgehog off state

2 of 132

1.95

1.77

0.0024

MAP-68867

Assembly of the pre-replicative complex

2 of 138

1.93

1.76

0.0024

MAP-69239

Synthesis of DNA

2 of 142

1.92

1.75

0.0024

MAP-6804756

Regulation of TP53 Activity through Phosphorylation

2 of 140

1.93

1.75

0.0024

MAP-5621481

C-type lectin receptors (CLRs)

2 of 142

1.92

1.75

0.0024

MAP-445989

TAK1-dependent IKK and NF-kappa-B activation

2 of 141

1.92

1.75

0.0024

MAP-5696398

Nucleotide Excision Repair

2 of 146

1.91

1.74

0.0024

MAP-5693565

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

2 of 147

1.9

1.74

0.0024

MAP-9006936

Signaling by TGFB family members

2 of 153

1.89

1.73

0.0024

MAP-5693606

DNA Double Strand Break Response

2 of 151

1.89

1.73

0.0024

MAP-69002

DNA Replication Pre-Initiation

2 of 159

1.87

1.71

0.0025

MAP-9020702

Interleukin-1 signaling

2 of 162

1.86

1.69

0.0026

MAP-2871837

FCERI mediated NF-kB activation

2 of 163

1.86

1.69

0.0026

MAP-453279

Mitotic G1 phase and G1/S transition

2 of 165

1.85

1.68

0.0027

MAP-9612973

Autophagy

2 of 170

1.84

1.66

0.0028

MAP-1632852

Macroautophagy

2 of 170

1.84

1.66

0.0028

MAP-8856825

Cargo recognition for clathrin-mediated endocytosis

2 of 178

1.82

1.63

0.0031

MAP-6807070

PTEN Regulation

2 of 179

1.82

1.63

0.0031

MAP-446652

Interleukin-1 family signaling

2 of 178

1.82

1.63

0.0031

MAP-3858494

Beta-catenin independent WNT signaling

2 of 180

1.82

1.62

0.0031

MAP-5358351

Signaling by Hedgehog

2 of 185

1.8

1.61

0.0032

MAP-73887

Death Receptor Signaling

2 of 187

1.8

1.6

0.0033

MAP-69242

S Phase

2 of 191

1.79

1.59

0.0034

MAP-5357801

Programmed Cell Death

2 of 190

1.79

1.59

0.0034

MAP-69306

DNA Replication

2 of 195

1.78

1.57

0.0035

MAP-9609507

Protein localization

2 of 200

1.77

1.55

0.0037

MAP-168164

Toll Like Receptor 3 (TLR3) Cascade

2 of 200

1.77

1.55

0.0037

MAP-975871

MyD88 cascade initiated on plasma membrane

2 of 206

1.76

1.54

0.0038

MAP-975155

MyD88 dependent cascade initiated on endosome

2 of 204

1.76

1.54

0.0038

MAP-975138

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

2 of 204

1.76

1.54

0.0038

MAP-2559583

Cellular Senescence

2 of 207

1.76

1.54

0.0038

MAP-181438

Toll Like Receptor 2 (TLR2) Cascade

2 of 207

1.76

1.54

0.0038

MAP-168188

Toll Like Receptor TLR6:TLR2 Cascade

2 of 207

1.76

1.54

0.0038

MAP-168181

Toll Like Receptor 7/8 (TLR7/8) Cascade

2 of 204

1.76

1.54

0.0038

MAP-168179

Toll Like Receptor TLR1:TLR2 Cascade

2 of 207

1.76

1.54

0.0038

MAP-168176

Toll Like Receptor 5 (TLR5) Cascade

2 of 206

1.76

1.54

0.0038

MAP-168142

Toll Like Receptor 10 (TLR10) Cascade

2 of 207

1.76

1.54

0.0038

MAP-168138

Toll Like Receptor 9 (TLR9) Cascade

2 of 205

1.76

1.54

0.0038

MAP-166058

MyD88:MAL(TIRAP) cascade initiated on plasma membrane

2 of 207

1.76

1.54

0.0038

MAP-937061

TRIF(TICAM1)-mediated TLR4 signaling

2 of 211

1.75

1.53

0.0038

MAP-166166

MyD88-independent TLR4 cascade

2 of 211

1.75

1.53

0.0038

MAP-5693567

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

2 of 215

1.74

1.52

0.0039

MAP-5687128

MAPK6/MAPK4 signaling

2 of 216

1.74

1.52

0.0039

MAP-8878171

Transcriptional regulation by RUNX1

2 of 221

1.73

1.5

0.0041

MAP-69275

G2/M Transition

2 of 222

1.73

1.5

0.0041

MAP-5693538

Homology Directed Repair

2 of 223

1.72

1.5

0.0041

MAP-166016

Toll Like Receptor 4 (TLR4) Cascade

2 of 222

1.73

1.5

0.0041

MAP-9711123

Cellular response to chemical stress

2 of 225

1.72

1.49

0.0042

MAP-453274

Mitotic G2-G2/M phases

2 of 225

1.72

1.49

0.0042

MAP-2467813

Separation of Sister Chromatids

2 of 228

1.71

1.49

0.0042

MAP-5633007

Regulation of TP53 Activity

2 of 234

1.7

1.46

0.0045

MAP-8856828

Clathrin-mediated endocytosis

2 of 239

1.69

1.45

0.0046

MAP-5689880

Ub-specific processing proteases

2 of 247

1.68

1.43

0.0049

MAP-168898

Toll-like Receptor Cascades

2 of 254

1.67

1.41

0.0052

MAP-983705

Signaling by the B Cell Receptor (BCR)

2 of 257

1.66

1.4

0.0053

MAP-69481

G2/M Checkpoints

2 of 260

1.66

1.4

0.0053

MAP-5693532

DNA Double-Strand Break Repair

2 of 258

1.66

1.4

0.0053

MAP-201681

TCF dependent signaling in response to WNT

2 of 258

1.66

1.4

0.0053

MAP-2454202

Fc epsilon receptor (FCERI) signaling

2 of 267

1.65

1.38

0.0056

MAP-68882

Mitotic Anaphase

2 of 292

1.61

1.32

0.0066

MAP-2555396

Mitotic Metaphase and Anaphase

2 of 295

1.6

1.31

0.0067

MAP-1257604

PIP3 activates AKT signaling

2 of 350

1.53

1.19

0.0094

MAP-8951664

Neddylation

2 of 369

1.5

1.16

0.0104

MAP-5673001

RAF/MAP kinase cascade

2 of 372

1.5

1.15

0.0105

MAP-5684996

MAPK1/MAPK3 signaling

2 of 379

1.49

1.14

0.0108

MAP-9006925

Intracellular signaling by second messengers

2 of 398

1.47

1.11

0.0119

MAP-69620

Cell Cycle Checkpoints

2 of 413

1.46

1.09

0.0127

MAP-195721

Signaling by WNT

2 of 413

1.46

1.09

0.0127

MAP-5688426

Deubiquitination

2 of 433

1.44

1.06

0.0138

MAP-446203

Asparagine N-linked glycosylation

2 of 433

1.44

1.06

0.0138

MAP-9675108

Nervous system development

2 of 479

1.39

1.0

0.0167

MAP-3700989

Transcriptional Regulation by TP53

2 of 484

1.39

0.99

0.0170

MAP-73894

DNA Repair

2 of 490

1.38

0.98

0.0174

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

2 of 510

1.36

0.96

0.0187

MAP-68886

M Phase

2 of 516

1.36

0.95

0.0191

MAP-5683057

MAPK family signaling cascades

2 of 548

1.33

0.92

0.0214

MAP-449147

Signaling by Interleukins

2 of 556

1.33

0.91

0.0219

MAP-983169

Class I MHC mediated antigen processing & presentation

2 of 595

1.3

0.87

0.0249

MAP-9006934

Signaling by Receptor Tyrosine Kinases

2 of 614

1.28

0.85

0.0264

MAP-69278

Cell Cycle, Mitotic

2 of 696

1.23

0.78

0.0336

MAP-1266738

Developmental Biology

2 of 780

1.18

0.72

0.0418

MAP-1280215

Cytokine Signaling in Immune system

2 of 783

1.18

0.72

0.0419

MAP-2262752

Cellular responses to stress

2 of 820

1.16

0.69

0.0457

MAP-8953897

Cellular responses to stimuli

2 of 833

1.15

0.69

0.0470

(more ...)

(less ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019956

Ubiquitin domain

2 of 14

2.93

1.34

0.0185

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00213

Ubiquitin homologues

2 of 39

2.48

1.41

0.0138

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102689647	PDGFB	ENSLOCP00000018914	ENSLOCP00000014057	Tetraspanin.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.416
LOC102689647	adam10	ENSLOCP00000018914	ENSLOCP00000016788	Tetraspanin.	ADAM metallopeptidase domain 10b.	0.517
LOC102689647	cd9	ENSLOCP00000018914	ENSLOCP00000021060	Tetraspanin.	Tetraspanin.	0.466
LOC102689647	met	ENSLOCP00000018914	ENSLOCP00000019200	Tetraspanin.	MET proto-oncogene, receptor tyrosine kinase.	0.593
LOC102689647	mst1r	ENSLOCP00000018914	ENSLOCP00000013339	Tetraspanin.	Macrophage stimulating 1 receptor b.	0.593
LOC102689647	ptgfrn	ENSLOCP00000018914	ENSLOCP00000013748	Tetraspanin.	Si:ch211-132g1.7.	0.411
PDGFB	LOC102689647	ENSLOCP00000014057	ENSLOCP00000018914	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	Tetraspanin.	0.416
PDGFB	cd9	ENSLOCP00000014057	ENSLOCP00000021060	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	Tetraspanin.	0.416
PDGFB	met	ENSLOCP00000014057	ENSLOCP00000019200	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	MET proto-oncogene, receptor tyrosine kinase.	0.878
PDGFB	mst1r	ENSLOCP00000014057	ENSLOCP00000013339	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	Macrophage stimulating 1 receptor b.	0.878
adam10	LOC102689647	ENSLOCP00000016788	ENSLOCP00000018914	ADAM metallopeptidase domain 10b.	Tetraspanin.	0.517
adam10	cd9	ENSLOCP00000016788	ENSLOCP00000021060	ADAM metallopeptidase domain 10b.	Tetraspanin.	0.558
cd9	LOC102689647	ENSLOCP00000021060	ENSLOCP00000018914	Tetraspanin.	Tetraspanin.	0.466
cd9	PDGFB	ENSLOCP00000021060	ENSLOCP00000014057	Tetraspanin.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.416
cd9	adam10	ENSLOCP00000021060	ENSLOCP00000016788	Tetraspanin.	ADAM metallopeptidase domain 10b.	0.558
cd9	met	ENSLOCP00000021060	ENSLOCP00000019200	Tetraspanin.	MET proto-oncogene, receptor tyrosine kinase.	0.611
cd9	mst1r	ENSLOCP00000021060	ENSLOCP00000013339	Tetraspanin.	Macrophage stimulating 1 receptor b.	0.611
cd9	ptgfrn	ENSLOCP00000021060	ENSLOCP00000013748	Tetraspanin.	Si:ch211-132g1.7.	0.923
met	LOC102689647	ENSLOCP00000019200	ENSLOCP00000018914	MET proto-oncogene, receptor tyrosine kinase.	Tetraspanin.	0.593
met	PDGFB	ENSLOCP00000019200	ENSLOCP00000014057	MET proto-oncogene, receptor tyrosine kinase.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.878

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Experiments

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Databases

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Textmining

Fusion

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