node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFMID | CYB5R4 | ENSLOCP00000015613 | ENSLOCP00000020462 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Cytochrome b5 reductase 4. | 0.430 |
AFMID | aadat | ENSLOCP00000015613 | ENSLOCP00000015705 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Aminoadipate aminotransferase. | 0.903 |
AFMID | aasdh | ENSLOCP00000015613 | ENSLOCP00000017274 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Aminoadipate-semialdehyde dehydrogenase. | 0.531 |
AFMID | kmo | ENSLOCP00000015613 | ENSLOCP00000020480 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.942 |
AFMID | kyat1 | ENSLOCP00000015613 | ENSLOCP00000004934 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynurenine aminotransferase 1. | 0.904 |
AFMID | kyat3 | ENSLOCP00000015613 | ENSLOCP00000006063 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynurenine aminotransferase 3. | 0.904 |
AFMID | kynu | ENSLOCP00000015613 | ENSLOCP00000001423 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 0.962 |
AFMID | pemt | ENSLOCP00000015613 | ENSLOCP00000002139 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. | 0.570 |
CYB5R4 | AFMID | ENSLOCP00000020462 | ENSLOCP00000015613 | Cytochrome b5 reductase 4. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.430 |
CYB5R4 | aasdh | ENSLOCP00000020462 | ENSLOCP00000017274 | Cytochrome b5 reductase 4. | Aminoadipate-semialdehyde dehydrogenase. | 0.473 |
CYB5R4 | kmo | ENSLOCP00000020462 | ENSLOCP00000020480 | Cytochrome b5 reductase 4. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.925 |
CYB5R4 | kyat1 | ENSLOCP00000020462 | ENSLOCP00000004934 | Cytochrome b5 reductase 4. | Kynurenine aminotransferase 1. | 0.478 |
CYB5R4 | kyat3 | ENSLOCP00000020462 | ENSLOCP00000006063 | Cytochrome b5 reductase 4. | Kynurenine aminotransferase 3. | 0.478 |
CYB5R4 | kynu | ENSLOCP00000020462 | ENSLOCP00000001423 | Cytochrome b5 reductase 4. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 0.662 |
aadat | AFMID | ENSLOCP00000015705 | ENSLOCP00000015613 | Aminoadipate aminotransferase. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.903 |
aadat | aasdh | ENSLOCP00000015705 | ENSLOCP00000017274 | Aminoadipate aminotransferase. | Aminoadipate-semialdehyde dehydrogenase. | 0.945 |
aadat | agxt | ENSLOCP00000015705 | ENSLOCP00000007880 | Aminoadipate aminotransferase. | Serine--pyruvate aminotransferase. | 0.492 |
aadat | kmo | ENSLOCP00000015705 | ENSLOCP00000020480 | Aminoadipate aminotransferase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.938 |
aadat | kyat1 | ENSLOCP00000015705 | ENSLOCP00000004934 | Aminoadipate aminotransferase. | Kynurenine aminotransferase 1. | 0.920 |
aadat | kyat3 | ENSLOCP00000015705 | ENSLOCP00000006063 | Aminoadipate aminotransferase. | Kynurenine aminotransferase 3. | 0.920 |