GPR119 protein (Lepisosteus oculatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

GPR119

G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (321 aa)

Predicted Functional Partners:

gnal

0.897

W5NMQ4_LEPOC

0.897

pomc

0.828

W5MYS6_LEPOC

0.815

LOC102693960

0.671

gcg

0.671

W5LZ17_LEPOC

0.639

gnb1

0.639

gnb3

0.639

W5N7N1_LEPOC

0.639

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GPR119	LOC102693960	ENSLOCP00000021590	ENSLOCP00000010332	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family.	0.671
GPR119	W5LZ17_LEPOC	ENSLOCP00000021590	ENSLOCP00000001374	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide binding protein (G protein), beta polypeptide 4b.	0.639
GPR119	W5MYS6_LEPOC	ENSLOCP00000021590	ENSLOCP00000013535	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.	Adenylate cyclase activating polypeptide 1a.	0.815
GPR119	W5N7N1_LEPOC	ENSLOCP00000021590	ENSLOCP00000016640	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.639
GPR119	W5NMQ4_LEPOC	ENSLOCP00000021590	ENSLOCP00000021913	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.897
GPR119	gcg	ENSLOCP00000021590	ENSLOCP00000010345	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.	Glucagon b.	0.671
GPR119	gnal	ENSLOCP00000021590	ENSLOCP00000002598	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.897
GPR119	gnb1	ENSLOCP00000021590	ENSLOCP00000007434	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	0.639
GPR119	gnb3	ENSLOCP00000021590	ENSLOCP00000009443	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide binding protein (G protein), beta polypeptide 3a.	0.639
GPR119	pomc	ENSLOCP00000021590	ENSLOCP00000020612	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.	Proopiomelanocortin b.	0.828
LOC102693960	GPR119	ENSLOCP00000010332	ENSLOCP00000021590	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family.	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.	0.671
LOC102693960	W5LZ17_LEPOC	ENSLOCP00000010332	ENSLOCP00000001374	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family.	Guanine nucleotide binding protein (G protein), beta polypeptide 4b.	0.560
LOC102693960	W5N7N1_LEPOC	ENSLOCP00000010332	ENSLOCP00000016640	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.560
LOC102693960	W5NMQ4_LEPOC	ENSLOCP00000010332	ENSLOCP00000021913	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family.	Uncharacterized protein.	0.663
LOC102693960	gnal	ENSLOCP00000010332	ENSLOCP00000002598	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family.	Uncharacterized protein.	0.663
LOC102693960	gnb1	ENSLOCP00000010332	ENSLOCP00000007434	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family.	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	0.560
LOC102693960	gnb3	ENSLOCP00000010332	ENSLOCP00000009443	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family.	Guanine nucleotide binding protein (G protein), beta polypeptide 3a.	0.560
W5LZ17_LEPOC	GPR119	ENSLOCP00000001374	ENSLOCP00000021590	Guanine nucleotide binding protein (G protein), beta polypeptide 4b.	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.	0.639
W5LZ17_LEPOC	LOC102693960	ENSLOCP00000001374	ENSLOCP00000010332	Guanine nucleotide binding protein (G protein), beta polypeptide 4b.	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family.	0.560
W5LZ17_LEPOC	W5MYS6_LEPOC	ENSLOCP00000001374	ENSLOCP00000013535	Guanine nucleotide binding protein (G protein), beta polypeptide 4b.	Adenylate cyclase activating polypeptide 1a.	0.489

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

2.95e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 328

1.8

4.86

1.46e-16

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 159

2.07

6.34

2.75e-17

GO:0019843

rRNA binding

3 of 51

2.05

1.36

0.0024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 184

2.01

5.98

5.37e-17

GO:0044391

Ribosomal subunit

4 of 135

1.75

1.71

0.00019

GO:0015935

Small ribosomal subunit

3 of 46

2.09

1.69

0.00050

GO:0022627

Cytosolic small ribosomal subunit

2 of 18

2.32

1.12

0.0086

GO:1990904

Ribonucleoprotein complex

5 of 555

1.23

1.04

0.0012

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28942070

(2017) Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison.

2 of 9

2.62

0.93

0.0209

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15235