STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5NN22_LEPOCTopoisomerase I binding, arginine/serine-rich b. (790 aa)    
Predicted Functional Partners:
sumo1
Small ubiquitin-related modifier.
    
 0.810
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.806
sumo3
Small ubiquitin-related modifier.
    
 0.740
sumo2
Small ubiquitin-related modifier.
    
 0.740
ube2i
Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.737
LOC102683539
UBIQUITIN_CONJUGAT_2 domain-containing protein.
    
 0.737
W5MZ98_LEPOC
UBIQUITIN_CONJUGAT_2 domain-containing protein.
    
 0.737
kctd2
Potassium channel tetramerization domain containing 2.
    
 0.726
ubxn7
UBX domain protein 7.
    
   0.680
senp7
SUMO specific peptidase 7.
   
  
 0.627
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.