node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCAR_003660 | DCAR_005780 | A0A166ID26 | A0A162ART2 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.958 |
DCAR_003660 | DCAR_007406 | A0A166ID26 | A0A161XHP4 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.934 |
DCAR_003660 | DCAR_011777 | A0A166ID26 | A0A166BXQ5 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.934 |
DCAR_003660 | DCAR_016389 | A0A166ID26 | A0A164XGC8 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | CMP/dCMP-type deaminase domain-containing protein. | 0.958 |
DCAR_003660 | DCAR_022987 | A0A166ID26 | A0A161ZSR8 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.999 |
DCAR_003660 | MCM7 | A0A166ID26 | A0A169WQB0 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.758 |
DCAR_005780 | DCAR_003660 | A0A162ART2 | A0A166ID26 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.958 |
DCAR_005780 | DCAR_007406 | A0A162ART2 | A0A161XHP4 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.836 |
DCAR_005780 | DCAR_009939 | A0A162ART2 | A0A161WR90 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Uncharacterized protein. | 0.719 |
DCAR_005780 | DCAR_011777 | A0A162ART2 | A0A166BXQ5 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.836 |
DCAR_005780 | DCAR_013871 | A0A162ART2 | A0A165Y2D3 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | RING-type E3 ubiquitin transferase. | 0.725 |
DCAR_005780 | DCAR_016389 | A0A162ART2 | A0A164XGC8 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | CMP/dCMP-type deaminase domain-containing protein. | 0.738 |
DCAR_005780 | DCAR_022987 | A0A162ART2 | A0A161ZSR8 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.958 |
DCAR_005780 | DCAR_024042 | A0A162ART2 | A0A164T0W6 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. | 0.725 |
DCAR_005780 | DCAR_024694 | A0A162ART2 | A0A164TIF8 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Uncharacterized protein. | 0.719 |
DCAR_005780 | MCM7 | A0A162ART2 | A0A169WQB0 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.759 |
DCAR_007406 | DCAR_003660 | A0A161XHP4 | A0A166ID26 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.934 |
DCAR_007406 | DCAR_005780 | A0A161XHP4 | A0A162ART2 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.836 |
DCAR_007406 | DCAR_011777 | A0A161XHP4 | A0A166BXQ5 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.900 |
DCAR_007406 | DCAR_022987 | A0A161XHP4 | A0A161ZSR8 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.934 |