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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rap1aRAP1A, member of RAS oncogene family. (186 aa)    
Predicted Functional Partners:
krit1
KRIT1 ankyrin repeat containing.
    
 0.959
ENSCHAP00000011007
Afadin, adherens junction formation factor a.
    
 0.920
ENSCHAP00000016490
Intersectin 2b.
    
 0.915
ENSCHAP00000057857
Intersectin 2a.
    
 0.915
ENSCHAP00000000512
annotation not available
    
 0.899
ENSCHAP00000015314
annotation not available
    
 0.899
ENSCHAP00000056429
Rap guanine nucleotide exchange factor (GEF) 6.
    
 0.877
rassf5
Ras association domain family member 5.
    
 0.876
ENSCHAP00000000387
annotation not available
    
 0.865
ENSCHAP00000035267
Intersectin 1 (SH3 domain protein).
    
 0.865
Your Current Organism:
Clupea harengus
NCBI taxonomy Id: 7950
Other names: Atlantic herring, C. harengus, Clupea harengus harengus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.