ENSCHAP00000011312 protein (Clupea harengus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSCHAP00000011312

cAMP responsive element binding protein 3-like 3b. (441 aa)

Predicted Functional Partners:

CREB1

0.915

LOC105904318

0.901

ENSCHAP00000025501

0.875

ENSCHAP00000028881

0.860

ENSCHAP00000056547

0.857

ENSCHAP00000013644

0.854

CREB3L4

0.840

ENSCHAP00000028374

0.839

creb3l2

0.838

ENSCHAP00000060104

0.838

Your Current Organism:

Clupea harengus

NCBI taxonomy Id: 7950
Other names: Atlantic herring, C. harengus, Clupea harengus harengus

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREB1	CREB3L4	ENSCHAP00000028572	ENSCHAP00000031770	cAMP responsive element binding protein 1.	cAMP responsive element binding protein 3 like 4.	0.898
CREB1	ENSCHAP00000011312	ENSCHAP00000028572	ENSCHAP00000011312	cAMP responsive element binding protein 1.	cAMP responsive element binding protein 3-like 3b.	0.915
CREB1	ENSCHAP00000013644	ENSCHAP00000028572	ENSCHAP00000013644	cAMP responsive element binding protein 1.	Ribosomal protein S6 kinase, polypeptide 5.	0.900
CREB1	ENSCHAP00000025501	ENSCHAP00000028572	ENSCHAP00000025501	cAMP responsive element binding protein 1.	CREB binding protein a.	0.977
CREB1	ENSCHAP00000028374	ENSCHAP00000028572	ENSCHAP00000028374	cAMP responsive element binding protein 1.	annotation not available	0.730
CREB1	ENSCHAP00000028881	ENSCHAP00000028572	ENSCHAP00000028881	cAMP responsive element binding protein 1.	cAMP responsive element binding protein 5b.	0.891
CREB1	ENSCHAP00000056547	ENSCHAP00000028572	ENSCHAP00000056547	cAMP responsive element binding protein 1.	Activating transcription factor 4a.	0.890
CREB1	ENSCHAP00000060104	ENSCHAP00000028572	ENSCHAP00000060104	cAMP responsive element binding protein 1.	cAMP responsive element binding protein 3-like 1.	0.912
CREB1	LOC105904318	ENSCHAP00000028572	ENSCHAP00000026698	cAMP responsive element binding protein 1.	Cyclic AMP-responsive element-binding protein 3-like.	0.915
CREB1	creb3l2	ENSCHAP00000028572	ENSCHAP00000020553	cAMP responsive element binding protein 1.	cAMP responsive element binding protein 3 like 2.	0.891
CREB3L4	CREB1	ENSCHAP00000031770	ENSCHAP00000028572	cAMP responsive element binding protein 3 like 4.	cAMP responsive element binding protein 1.	0.898
CREB3L4	ENSCHAP00000011312	ENSCHAP00000031770	ENSCHAP00000011312	cAMP responsive element binding protein 3 like 4.	cAMP responsive element binding protein 3-like 3b.	0.840
CREB3L4	ENSCHAP00000013644	ENSCHAP00000031770	ENSCHAP00000013644	cAMP responsive element binding protein 3 like 4.	Ribosomal protein S6 kinase, polypeptide 5.	0.855
CREB3L4	ENSCHAP00000025501	ENSCHAP00000031770	ENSCHAP00000025501	cAMP responsive element binding protein 3 like 4.	CREB binding protein a.	0.874
CREB3L4	ENSCHAP00000028374	ENSCHAP00000031770	ENSCHAP00000028374	cAMP responsive element binding protein 3 like 4.	annotation not available	0.722
CREB3L4	ENSCHAP00000028881	ENSCHAP00000031770	ENSCHAP00000028881	cAMP responsive element binding protein 3 like 4.	cAMP responsive element binding protein 5b.	0.869
CREB3L4	ENSCHAP00000056547	ENSCHAP00000031770	ENSCHAP00000056547	cAMP responsive element binding protein 3 like 4.	Activating transcription factor 4a.	0.830
CREB3L4	ENSCHAP00000060104	ENSCHAP00000031770	ENSCHAP00000060104	cAMP responsive element binding protein 3 like 4.	cAMP responsive element binding protein 3-like 1.	0.826
CREB3L4	LOC105904318	ENSCHAP00000031770	ENSCHAP00000026698	cAMP responsive element binding protein 3 like 4.	Cyclic AMP-responsive element-binding protein 3-like.	0.848
CREB3L4	creb3l2	ENSCHAP00000031770	ENSCHAP00000020553	cAMP responsive element binding protein 3 like 4.	cAMP responsive element binding protein 3 like 2.	0.826

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

47

PPI enrichment p-value:

0.0318

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 309

1.77

4.66

3.02e-16

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 155

2.03

6.04

7.21e-17

GO:0019843

rRNA binding

4 of 43

2.19

2.52

1.03e-05

GO:0003723

RNA binding

6 of 1039

0.98

0.69

0.0076

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 177

1.97

5.71

1.28e-16

GO:0044391

Ribosomal subunit

7 of 130

1.95

3.98

2.21e-10

GO:0015935

Small ribosomal subunit

4 of 48

2.14

2.6

5.79e-06

GO:0022626

Cytosolic ribosome

4 of 52

2.11

2.56

6.27e-06

GO:0015934

Large ribosomal subunit

3 of 81

1.79

1.29

0.0023

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14887

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

10 of 101

2.22

7.32

1.83e-18

CL:14896

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

9 of 90

2.22

6.89

5.10e-17

CL:14897

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

7 of 78

2.18

5.13

3.18e-12

CL:14902

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

6 of 69

2.16

4.31

4.44e-10

CL:14907

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

4 of 45

2.17

2.72

3.52e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 176

1.98

5.91

1.90e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

8 of 108

2.09

5.17

5.36e-13

MAP-72737

Cap-dependent Translation Initiation

8 of 124

2.03

4.94

7.74e-13

MAP-72613

Eukaryotic Translation Initiation

8 of 124

2.03

4.94

7.74e-13

MAP-975956

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

7 of 94

2.09

4.68

1.66e-11

MAP-72689

Formation of a pool of free 40S subunits

7 of 98

2.08

4.63

1.75e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022626

Cytosolic ribosome

6 of 51

2.29

4.51

4.67e-10

GOCC:0022627

Cytosolic small ribosomal subunit

5 of 25

2.52

4.4

2.82e-09

GOCC:1990904

Ribonucleoprotein complex

6 of 402

1.4

1.66

1.22e-05

GOCC:0043232

Intracellular non-membrane-bounded organelle

7 of 1957

0.78

0.55

0.0066

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

5 of 59

2.15

3.44

6.54e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04758

Ribosomal protein S30

3 of 3

3.22

2.86

6.73e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006846

Ribosomal protein S30

2 of 2

3.22

1.05

0.0130

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