ENSCHAP00000015911 protein (Clupea harengus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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Score

ENSCHAP00000015911

Glutathione S-transferase rho. (159 aa)

Predicted Functional Partners:

ENSCHAP00000026988

0.993

ENSCHAP00000029605

0.881

eef1g

0.879

eef1b2

0.854

eef1d

0.854

ENSCHAP00000021140

0.810

ENSCHAP00000023390

0.810

ENSCHAP00000024235

0.810

ENSCHAP00000035435

0.810

gsto1

0.763

Your Current Organism:

Clupea harengus

NCBI taxonomy Id: 7950
Other names: Atlantic herring, C. harengus, Clupea harengus harengus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCHAP00000015911	ENSCHAP00000021140	ENSCHAP00000015911	ENSCHAP00000021140	Glutathione S-transferase rho.	Aminoacyl tRNA synthetase complex interacting multifunctional protein 2.	0.810
ENSCHAP00000015911	ENSCHAP00000023390	ENSCHAP00000015911	ENSCHAP00000023390	Glutathione S-transferase rho.	Fumarylacetoacetate hydrolase (fumarylacetoacetase).	0.810
ENSCHAP00000015911	ENSCHAP00000024235	ENSCHAP00000015911	ENSCHAP00000024235	Glutathione S-transferase rho.	RNA polymerase I and III subunit C.	0.810
ENSCHAP00000015911	ENSCHAP00000026988	ENSCHAP00000015911	ENSCHAP00000026988	Glutathione S-transferase rho.	glutamyl-prolyl-tRNA synthetase 1.	0.993
ENSCHAP00000015911	ENSCHAP00000029605	ENSCHAP00000015911	ENSCHAP00000029605	Glutathione S-transferase rho.	lysyl-tRNA synthetase 1.	0.881
ENSCHAP00000015911	ENSCHAP00000035435	ENSCHAP00000015911	ENSCHAP00000035435	Glutathione S-transferase rho.	Polymerase (RNA) II (DNA directed) polypeptide C.	0.810
ENSCHAP00000015911	eef1b2	ENSCHAP00000015911	ENSCHAP00000003844	Glutathione S-transferase rho.	Eukaryotic translation elongation factor 1 beta 2.	0.854
ENSCHAP00000015911	eef1d	ENSCHAP00000015911	ENSCHAP00000006537	Glutathione S-transferase rho.	Eukaryotic translation elongation factor 1 delta.	0.854
ENSCHAP00000015911	eef1g	ENSCHAP00000015911	ENSCHAP00000052046	Glutathione S-transferase rho.	Eukaryotic translation elongation factor 1 gamma.	0.879
ENSCHAP00000015911	gsto1	ENSCHAP00000015911	ENSCHAP00000042811	Glutathione S-transferase rho.	Glutathione S-transferase omega 1.	0.763
ENSCHAP00000021140	ENSCHAP00000015911	ENSCHAP00000021140	ENSCHAP00000015911	Aminoacyl tRNA synthetase complex interacting multifunctional protein 2.	Glutathione S-transferase rho.	0.810
ENSCHAP00000021140	ENSCHAP00000026988	ENSCHAP00000021140	ENSCHAP00000026988	Aminoacyl tRNA synthetase complex interacting multifunctional protein 2.	glutamyl-prolyl-tRNA synthetase 1.	0.999
ENSCHAP00000021140	ENSCHAP00000029605	ENSCHAP00000021140	ENSCHAP00000029605	Aminoacyl tRNA synthetase complex interacting multifunctional protein 2.	lysyl-tRNA synthetase 1.	0.998
ENSCHAP00000021140	eef1g	ENSCHAP00000021140	ENSCHAP00000052046	Aminoacyl tRNA synthetase complex interacting multifunctional protein 2.	Eukaryotic translation elongation factor 1 gamma.	0.944
ENSCHAP00000023390	ENSCHAP00000015911	ENSCHAP00000023390	ENSCHAP00000015911	Fumarylacetoacetate hydrolase (fumarylacetoacetase).	Glutathione S-transferase rho.	0.810
ENSCHAP00000023390	eef1g	ENSCHAP00000023390	ENSCHAP00000052046	Fumarylacetoacetate hydrolase (fumarylacetoacetase).	Eukaryotic translation elongation factor 1 gamma.	0.713
ENSCHAP00000024235	ENSCHAP00000015911	ENSCHAP00000024235	ENSCHAP00000015911	RNA polymerase I and III subunit C.	Glutathione S-transferase rho.	0.810
ENSCHAP00000024235	ENSCHAP00000026988	ENSCHAP00000024235	ENSCHAP00000026988	RNA polymerase I and III subunit C.	glutamyl-prolyl-tRNA synthetase 1.	0.744
ENSCHAP00000024235	ENSCHAP00000029605	ENSCHAP00000024235	ENSCHAP00000029605	RNA polymerase I and III subunit C.	lysyl-tRNA synthetase 1.	0.793
ENSCHAP00000024235	ENSCHAP00000035435	ENSCHAP00000024235	ENSCHAP00000035435	RNA polymerase I and III subunit C.	Polymerase (RNA) II (DNA directed) polypeptide C.	0.859

page 1 of 4

Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.414

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060070

Canonical Wnt signaling pathway

3 of 81

1.9

0.9

0.0189

GO:0016055

Wnt signaling pathway

4 of 216

1.6

0.85

0.0185

GO:0090090

Negative regulation of canonical Wnt signaling pathway

3 of 98

1.82

0.83

0.0247

GO:0046849

Bone remodeling

2 of 14

2.49

0.83

0.0304

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071936

Coreceptor activity involved in Wnt signaling pathway

2 of 2

3.33

1.39

0.0031

GO:0039706

Co-receptor binding

2 of 7

2.79

1.12

0.0094

GO:0048019

Receptor antagonist activity

2 of 9

2.68

1.11

0.0095

GO:0042813

Wnt receptor activity

2 of 18

2.38

0.93

0.0197

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071821

FANCM-MHF complex

2 of 5

2.93

1.26

0.0052

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37339990

(2023) TGFbeta inhibition and mesenchymal to epithelial transition initiation by Xenopus egg extract: first steps towards early reprogramming in fish somatic cell.

3 of 42

2.19

1.18

0.0061

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21213

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

4 of 6

3.16

4.15

2.70e-08

CL:21106

Wnt signaling pathway, and Negative regulation of TCF-dependent signaling by WNT ligand antagonists

5 of 61

2.25

3.36

1.69e-07

CL:1161

Mixed, incl. Centromere complex assembly, and Carbohydrate-binding WSC

2 of 16

2.43

0.94

0.0190

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ola04310

Wnt signaling pathway

3 of 180

1.55

0.91

0.0120

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3772470

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

5 of 12

2.95

5.44

7.75e-11

MAP-201681

TCF dependent signaling in response to WNT

5 of 258

1.62

1.77

6.00e-05

MAP-195721

Signaling by WNT

5 of 413

1.41

1.33

0.00040

MAP-4641263

Regulation of FZD by ubiquitination

2 of 22

2.29

0.95

0.0180

MAP-162582

Signal Transduction

9 of 4038

0.68

0.53

0.0021

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990851

Wnt-Frizzled-LRP5/6 complex

2 of 2

3.33

1.53

0.0018

GOCC:0071821

FANCM-MHF complex

2 of 5

2.93

1.52

0.0018

GOCC:0098797

Plasma membrane protein complex

5 of 479

1.35

1.09

0.0018

GOCC:0098796

Membrane protein complex

6 of 1010

1.11

0.9

0.0018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01822

WSC domain

2 of 2

3.33

1.43

0.0027

PF04706

Dickkopf N-terminal cysteine-rich region

2 of 6

2.85

1.22

0.0063

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002889

Carbohydrate-binding WSC

3 of 3

3.33

2.75

1.08e-05

IPR039863

Dickkopf-like protein

2 of 6

2.85

0.94

0.0198

IPR006796

Dickkopf, N-terminal cysteine-rich

2 of 6

2.85

0.94

0.0198

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